The response of the metabolic network of the red blood cell to pyruvate kinase deficiency

Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

Volumn 7 VOLS, Issue , 2005, Pages 913-916

  Xiaoliang, Sun ^a   Zuhong, Lu ^a  

^a SOUTHEAST UNIVERSITY   (China)

Author keywords

E Cell; Human red blood cell; Metabolic network; Pyruvate kinase deficiency

Indexed keywords

BLOOD; CELLS; COMPUTATIONAL METHODS; COMPUTER SIMULATION; ENZYMES; METABOLITES; REACTION KINETICS;

HUMAN RED BLOOD CELLS; METABOLIC NETWORKS; PYRUVATE KINASE DEFICIENCY;

METABOLISM;

EID: 33846910016     PISSN: 05891019     EISSN: None     Source Type: Conference Proceeding    
DOI: None     Document Type: Conference Paper

References (11)

1. Zhinan Zhang and Rongsheng Li, "Basis of red blood cell diseases and clinic" (in Chinese), pp.53, Science Press, 2000
2. Alex Gilman and Adam P. Arkin, "Genetic 'Code': Representations and Dynamical Models of Genetic Components and Networks", Annu. Rev. Genomics Hum. Genet., pp.341-69, March 2002
3. Masaru Tomita, "Whole-cell simulation: a grand challenge of the 21st century", Trends in Biotechnology Vol.19 No.6, pp.205, June 2001
4. E-Cell 2.26 manual. Available: http://www.e-cell.org
5. Yoichi Nakayama, "Computer Simulation of Human Erythrocyte Using the E-CELL System". Available: http://www.e-cell.org
6. rd, pp.4, Academic Press, 1970
7. rd, pp.90, John Wiley & Sons, Inc, 2002
8. Dong K, Tang LQ, Macgregor GG, Leng Q, Hebert SC, "Novel nucleotide-binding sites in ATP-sensitive potassium channels formed at gating interfaces", EMBO J., Mar 172005; [Epub ahead of print]
9. El-Demerdash E, Awad AS, Taha RM, El-Hady AM, Sayed-Ahmed MM, "Probucol attenuates oxidative stress and energy decline in isoproterenol-induced heart failure in rat", Pharmacol Res., pp. 311-8, vol.51(4), Apr. 2005
10. Hardie DG, Carling D, Carlson M, "The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell?", Annu. Rev. Biochem., pp. 821-55, vol.67, 1998
11. Lakomek M, Winkler H., "Erythrocyte pyruvate kinase- and glucose phosphate isomerase deficiency: perturbation of glycolysis by structural defects and functional alterations of defective enzymes and its relation to the clinical severity of chronic hemolytic anemia", Biophys Chem., pp. 269-84, vol.66 (2-3), June 30 1997