Exhaled nasal nitric oxide output is reduced in humans at night during the sleep period

Respiratory Physiology and Neurobiology

Volumn 156, Issue 1, 2007, Pages 94-101

  O'Hearn, Daniel J ^a   Giraud, George D ^a   Sippel, Jeffrey M ^a   Edwards, Chad ^a   Chan, Benjamin ^a   Holden, William E ^a  

^a PORTLAND VA MEDICAL CENTER   (United States)

Author keywords

Nitric oxide; Nose; Sleep; Somnolence

Indexed keywords

N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE;

ADULT; ARTICLE; BODY POSITION; EXHALATION; FEMALE; HUMAN; HUMAN EXPERIMENT; HYPOTHESIS; LUNG MINUTE VOLUME; MALE; MEASUREMENT; NIGHT SLEEP; NORMAL HUMAN; NOSE AIRFLOW; NOSE MUCOSA; OXYGEN CONSUMPTION; PRIORITY JOURNAL; SOMNOLENCE; WAKEFULNESS;

ADULT; CARBON DIOXIDE; CIRCADIAN RHYTHM; EXHALATION; FEMALE; HUMANS; MALE; MIDDLE AGED; NITRIC OXIDE; OXYGEN CONSUMPTION; POSTURE; RESPIRATORY MECHANICS; SLEEP; STATISTICS, NONPARAMETRIC; TIDAL VOLUME;

EID: 33846897653     PISSN: 15699048     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.resp.2006.08.002     Document Type: Article

References (42)

1. ATS/ERS. Recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide. Am. J. Respir. Crit. Care Med. 171 (2005) 912-930
2. Bartley J., Fergusson W., Moody A., Wells A.U., and Kolbe J. Normal adult values, diurnal variation, and repeatability of nasal nitric oxide measurement. Am. J. Rhinol. 13 (1999) 401-405
3. Birchfield R.I., Sieker H.O., and Heyman A. Alterations in blood gases during natural sleep and narcolepsy. Neurology 8 (1958) 107-112
4. Birchfield R.I., Sieker H.O., and Heyman A. Alterations in respiratory function during natural sleep. J. Lab. Clin. Med. 54 (1959) 216-222
5. Borgonio A., Witte K., Stahrenberg R., and Lemmer B. Influence of circadian time, ageing, and hypertension on the urinary excretion of nitric oxide metabolites in rats. Mech. Ageing Dev. 111 (1999) 23-37
6. Burgess K., and Whitelaw W. Reducing ventilatory response to carbon dioxide by breathing cold air. Am. Rev. Respir. Dis. 129 (1984) 687-690
7. Burlet S., and Cespuglio R. Voltammetric detection of nitric oxide (NO) in the rat brain: its variations throughout the sleep-wake cycle. Neurosci. Lett. 226 (1997) 131-135
8. Carlin R., Ferrario L., Boyd J.T., Camporesi E.M., McGraw D.J., and Hakim T.S. Determinants of nitric oxide in exhaled gas in isolated rabbit lung. Am. J. Respir. Crit. Care Med. 155 (1997) 922-927
9. Chambers D.C., Carpenter D.A., and Ayres J.G. Exchange dynamics of nitric oxide in the human nose. J. Appl. Physiol. 91 (2001) 1924-1930
10. Chatkin J.M., Djupesland P.G., Qian W., McClean P., Furlott H., Gutierrez C., Zamel N., and Haight J.S. Nasal nitric oxide is independent of nasal cavity volume. Am. J. Rhinol. 13 (1999) 179-184
11. Djupesland P.G., Chatkin J.M., Qian W., Cole P., Zamel N., McClean P., Furlott H., and Haight J.S. Aerodynamic influences on nasal nitric oxide output measurements. Acta Otolaryngol. 119 (1999) 479-485
12. Douglas N.J., White D.P., Pickett C.K., Weil J.V., and Zwillich C.W. Respiration during sleep in normal man. Thorax 37 (1982) 840-844
13. Dubois A.B., Douglas J.S., Stitt J.T., and Mohsenin V. Production and absorption of nitric oxide gas in the nose. J. Appl. Physiol. 84 (1998) 1217-1224
14. DuBois A.B., Kelley P.M., Douglas J.S., and Mohsenin V. Nitric oxide production and absorption in trachea, bronchi, bronchioles, and respiratory bronchioles of humans. J. Appl. Physiol. 86 (1999) 159-167
15. Dzoljic M.R., and De Vries R. Nitric oxide synthase inhibition reduces wakefulness. Neuropharmacology 33 (1994) 1505-1509
16. Faradji H., Rousset C., Debilly G., Vergnes M., and Cespuglio R. Sleep and epilepsy: a key role for nitric oxide?. Epilepsia 41 (2000) 794-801
17. Fitzpatrick M.F., Driver H.S., Chatha N., Voduc N., and Girard A.M. Partitioning of inhaled ventilation between the nasal and oral routes during sleep in normal subjects. J. Appl. Physiol. 94 (2003) 883-890
18. Giraud G.D., Nejadnik B., Kimberly B., and Holden W.E. Physical characteristics and gas composition of nasal air affect nasal nitric oxide release. Respir. Physiol. 114 (1998) 285-296
19. Glotzbach S., and Heller H. Temperature regulation. In: Kryger M., Roth T., and Dement W. (Eds). Principles and Practice of Sleep Medicine (2000), W.B. Saunders Co., Phildelphia, PA 289-304
20. Grimminger F., Spriestersbach R., Weissman N., Walmrath D., and Seeger W. Nitric oxide generation and hypoxic vasoconstriction in buffer-perfused rabbit lungs. J. Appl. Physiol. 78 (1995) 1509-1515
21. Haight J.S.J., Qian W., Daya H., Chalmers P., and Zamel N. Hypoxia depresses nitric oxide output in the human nasal airways. Laryngoscope 110 (2000) 429-433
22. Holden W.E., Wilkins J.P., Harris M., Milczuk H.A., and Giraud G.D. Temperature conditioning of nasal air: effects of vasoactive agents and involvement of nitric oxide. J. Appl. Physiol. 87 (1999) 1260-1265
23. Imada M., Iwamoto J., Nonaka S., Kobayashi Y., and Unno T. Measurement of nitric oxide in human nasal airway. Eur. Respir. J. 9 (1996) 556-559
24. Imada M., Nonaka S., Kobayashi Y., and Iwamoto J. Functional roles of nasal nitric oxide in nasal patency and mucociliary function. Acta Otolaryngol. 122 (2002) 513-519
25. Kimberly B., Nejadnik B., Giraud G.D., and Holden W.E. Nasal contribution to exhaled nitric oxide at rest and during breathholding in humans. Am. J. Respir. Crit. Care Med. 153 (1996) 829-836
26. Lavie P., Fischel N., Zomer J., and Eliaschar I. The effects of partial and complete mechanical occlusion of the nasal passages on sleep structure and breathing in sleep. Acta Otolaryngol. 95 (1983) 161-166
27. Liu L., Yan Y., Zeng M., Zhang J., Hanes M.A., Ahearn G., McMahon T.J., Dickfield T., Marshall H.E., Que L.G., and Stamler J.S. Essential roles of S-nitrosothiols in vascular homeostasis and endotoxic shock. Cell 116 (2004) 617-628
28. Lundberg J.O., Weitzberg E., Nordvall S.L., Kuylenstierna R., Lundberg J.M., and Alving K. Primarily nasal origin of exhaled nitric oxide and absence in Kartagener's syndrome. Eur. Respir. J. 7 (1994) 1501-1504
29. Muller N.L., Francis P.W., Gurwitz D., Levison H., and Bryan A.C. Mechanism of hemoglobin desaturation during rapid-eye-movement sleep in normal subjects and in patients with cystic fibrosis. Am. Rev. Respir. Dis. 121 (1980) 463-469
30. Nelin L.D., Thomas C.J., and Dawson C.D. Effect of hypoxia on nitric oxide production in neonatal pig lung. Am. J. Physiol. 271 (1996) H8-H14
31. Neter J., Wasserman W., and Kutner M.H. Applied Linear Statistical Models: Regression, Analysis of Variance, and Experimental Designs (1990), Irwin, Homewood, IL
32. Palm J.P., Alving K., and Lundberg J.O. Characterization of airway nitric oxide in allergic rhinitis: the effect of intranasal administration of l-NAME. Allergy 58 (2003) 885-892
33. Palm J.P., Graf P., Lundberg J.O., and Alving K. Characterization of exhaled nitric oxide: introducing a new reproducible method for nasal nitric oxide measurements. Eur. Respir. J. 16 (2000) 236-241
34. Phillipson E.A., and Bowes G. Control of breathing during sleep. In: Cherniack N.S., and Widdicombe J.G. (Eds). Handbook of Physiology-Section 3: The Respiratory System vol. II (1986), American Physiological Society, Bethesda, MD 649-689
35. Rechtschaffen A., and Kales A. A manual of standardized terminology, techniques, and scoring system for sleep stages of human subjects. Brain Information Service/Brain Research Institute (1968), UCLA, Los Angeles, CA
36. Robin E.D., Whaley R.D., Crump C.H., and Travis D.H. Alveolar gas tensions, pulmonary ventilation and blood pH during physiologic sleep in normal subjects. J. Clin. Invest. 37 (1958) 981-989
37. Sippel J.M., Giraud G.D., and Holden W.E. Nasal administration of the nitric oxide synthase inhibitor l-NAME induces daytime somnolence. Sleep 22 (1999) 786-788
38. Speisman I.G. Vasomotor responses of the mucosa of the upper respiratory tract to thermal stimuli. Am. J. Physiol. 115 (1936) 181-187
39. ten Hacken N.H., van der Vaart H., van der Mark T.W., Koeter G.H., and Postma D.S. Exhaled nitric oxide is higher both at day and night in subjects with nocturnal asthma. Am. J. Respir. Crit. Care Med. 158 (1998) 902-907
40. Tornberg D.C., Marteus H., Schedin U., Alving K., Lundberg J.O., and Weitzberg E. Nasal and oral contribution to inhaled and exhaled nitric oxide: a study in tracheotomized patients. Eur. Respir. J. 19 (2002) 859-864
41. White M.D., and Cabanec M. Nasal mucosal vasodilatation in response to passive hyperthermia in humans. Eur. J. Appl. Physiol. 70 (1995) 207-212
42. Zwillich C.W., Pickett C., Hanson F.N., and Weil J.V. Disturbed sleep and prolonged apnea during nasal obstruction in normal men. Am. Rev. Respir. Dis. 124 (1981) 158-160