Evaluation of two-way protein fluxes across the alveolo-capillary membrane by scintigraphy in rats: Effect of lung inflation

Journal of Applied Physiology

Volumn 102, Issue 2, 2007, Pages 794-802

  De Prost, Nicolas ^a,b   Dreyfuss, Didier ^c   Saumon, Georges ^a,b,d  

^a INSERM   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

^d CENTRE DE RECHERCHE BIOMÉDICALE BICHAT BEAUJON CRB3   (France)

Author keywords

Blood air barrier; Intermittent positive pressure ventilation; Microvascular permeability

Indexed keywords

ALBUMIN TC 99M; INDIUM CHLORIDE IN 111; TRACER; TRANSFERRIN IN 111;

AIRWAY PRESSURE; ANIMAL EXPERIMENT; ARTICLE; ARTIFICIAL VENTILATION; BRONCHUS; CAPILLARY PERMEABILITY; CAPILLARY WALL; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; EVALUATION; IN VIVO STUDY; LUNG ALVEOLUS EPITHELIUM; LUNG CAPILLARY; LUNG DIFFUSION; LUNG HEMODYNAMICS; LUNG INFLATION; LUNG PARENCHYMA; LUNG SCINTISCANNING; MALE; MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT; RAT; TIDAL VOLUME;

ANIMALS; BLOOD-AIR BARRIER; CELL MEMBRANE PERMEABILITY; ENDOTHELIUM, VASCULAR; INDIUM RADIOISOTOPES; LUNG; MALE; MATHEMATICS; PULMONARY ALVEOLI; RADIONUCLIDE IMAGING; RATS; RATS, WISTAR; RESPIRATION, ARTIFICIAL; RESPIRATORY MUCOSA; TECHNETIUM TC 99M AGGREGATED ALBUMIN; TOMOGRAPHY, X-RAY COMPUTED; TRANSFERRIN;

EID: 33846889011     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00742.2006     Document Type: Article

References (54)

1. Azghani AO, Connelly JC, Peterson BT, Gray LD, Collins ML, Johnson AR. Effects of Pseudomonas aeruginosa elastase on alveolar epithelial permeability in guinea pigs. Infect Immun 58: 433-438., 1990.
2. Basran GS, Byrne AJ, Hardy JG. A noninvasive technique for monitoring lung vascular permeability in man. Nucl Med Commun 6: 3-10, 1985.
3. Basset G, Crone C, Saumon G. Fluid absorption by rat lung in situ: pathways for sodium entry in the luminal membrane of alveolar epithelium. J Physiol 384: 325-345, 1987.
4. Berthiaume Y, Albertine KH, Grady M, Fick G, Matthay MA. Protein clearance from the air spaces and lungs of unanesthetized sheep over 144 h. J Appl Physiol 67: 1887-1897, 1989.
5. Bilek AM, Dee KC, Gaver DP III. Mechanisms of surface-tension- induced epithelial cell damage in a model of pulmonary airway reopening. J Appl Physiol 94: 770-783, 2003.
6. Bouvet F, Dreyfuss D, Lebtahi R, Martet G, Le Guludec D, Saumon G. Noninvasive evaluation of acute capillary permeability changes during high-volume ventilation in rats with and without hypercapnic acidosis. Crit Care Med 33: 155-160, 2005.
7. Carter EP, Matthay MA, Farinas J, Verkman AS. Transalveolar osmotic and diffusional water permeability in intact mouse lung measured by a novel surface fluorescence method. J Gen Physiol 108: 133-142, 1996.
8. Cavanaugh KJ, Cohen TS, Margulies SS. Stretch increases alveolar epithelial permeability to uncharged micromolecules. Am J Physiol Cell Physiol 290: C1179-C1188, 2006.
9. Cohen DS, Matthay MA, Cogan MG, Murray JF. Pulmonary edema associated with salt water near-drowning: new insights. Am Rev Respir Dis 146: 794-796, 1992.
10. Dambrosio M, Roupie E, Mollet JJ, Anglade MC, Vasile N, Lemaire F, Brochard L. Effects of positive end-expiratory pressure and different tidal volumes on alveolar recruitment and hyperinflation. Anesthesiology 87: 495-503, 1997.
11. De Pasquale CG, Bersten AD, Doyle IR, Aylward PE, Arnolda LF. Infarct-induced chronic heart failure increases bidirectional protein movement across the alveolocapillary barrier. Am J Physiol Heart Circ Physiol 284: H2136-H2145, 2003.
12. 99mTc-labeled human serum albumin prepared with Sn(II) as the reductant. Int J Appl Radiat Isot 33: 1351-1357, 1982.
13. Dreyfuss D, Saumon G. Ventilator-induced lung injury: lessons from experimental studies. Am J Respir Crit Care Med 157: 294-323, 1998.
14. Dreyfuss D, Soler P, Saumon G. Spontaneous resolution of pulmonary edema caused by short periods of cyclic overinflation. J Appl Physiol 72: 2081-2089, 1992.
15. Egan EA. Lung inflation, lung solute permeability, and alveolar edema. J Appl Physiol 53: 121-125, 1982.
16. Egan EA, Nelson RM, Olver RE. Lung inflation and alveolar permeability to non-electrolytes in the adult sheep in vivo. J Physiol 260: 409-424, 1976.
17. Ermert L, Rossig R, Hansen T, Schutte H, Aktories K, Seeger W. Differential role of actin in lung endothelial and epithelial barrier properties in perfused rabbit lungs. Eur Respir J 9: 93-99, 1996.
18. Frank JA, Wray CM, McAuley DF, Schwendener R, Matthay MA. Alveolar macrophages contribute to alveolar barrier dysfunction in ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol 291: L1191-L1198, 2006.
19. Fu Z, Costello ML, Tsukimoto K, Prediletto R, Elliott AR, Mathieu-Costello O, West JB. High lung volume increases stress failure in pulmonary capillaries. J Appl Physiol 73: 123-133, 1992.
20. Gil J, Bachofen H, Gehr P, Weibel ER. Alveolar volume-surface area relation in air- and saline-filled lungs fixed by vascular perfusion. J Appl Physiol 47: 990-1001, 1979.
21. Gorin AB, Stewart PA. Differential permeability of endothelial and epithelial barriers to albumin flux. J Appl Physiol 47: 1315-1324, 1979.
22. Gorin AB, Weidner WJ, Demling RH, Staub NC. Noninvasive measurement of pulmonary transvascular protein flux in sheep. J Appl Physiol 45: 225-233, 1978.
23. Hastings RH, Folkesson HG, Matthay MA. Mechanisms of alveolar protein clearance in the intact lung. Am J Physiol Lung Cell Mol Physiol 286: L679-L689, 2004.
24. Havill AM, Gee MH. Role of interstitium in clearance of alveolar fluid in normal and injured lungs. J Appl Physiol 57: 1-6, 1984.
25. Jefferies AL, Fung D, Mullen JB. Fibrinogen depletion and control of permeability in oleic acid lung injury. Am Rev Respir Dis 143: 618-624, 1991.
26. John J, Taskar V, Evander E, Wollmer P, Jonson B. Additive nature of distension and surfactant perturbation on alveolocapillary permeability. Eur Respir J 10: 192-199, 1997.
27. Kawkitinarong K, Linz-McGillem L, Birukov KG, Garcia JG. Differential regulation of human lung epithelial and endothelial barrier function by thrombin. Am J Respir Cell Mol Biol 31: 517-527, 2004.
28. Kim KJ, Crandall ED. Effects of lung inflation on alveolar epithelial solute and water transport properties. J Appl Physiol 52: 1498-1505, 1982.
29. Marks JD, Luce JM, Lazar NM, Wu JN, Lipavsky A, Murray JF. Effect of increases in lung volume on clearance of aerosolized solute from human lungs. J Appl Physiol 59: 1242-1248, 1985.
30. Martin-Lefevre L, Ricard JD, Roupie E, Dreyfuss D, Saumon G. Significance of the changes in the respiratory system pressure-volume curve during acute lung injury in rats. Am J Respir Crit Care Med 164: 627-632, 2001.
31. Matthay MA, Berthiaume Y, Staub NC. Long-term clearance of liquid and protein from the lungs of unanesthetized sheep. J Appl Physiol 59: 928-934, 1985.
32. Minnear FL, Martin D, Hill L, Taylor AE, Malik AB. Lung morphological and permeability changes induced by intravascular coagulation in dogs. Am J Physiol Heart Circ Physiol 253: H634-H644, 1987.
33. 99mTc-DTPA clearance in humans. J Appl Physiol 60: 1493-1497, 1986.
34. Otsuki H, Brunetti A, Owens ES, Finn RD, Blasberg RG. Comparison of iron-59, indium-111, and gallium-69 transferrin as a macromolecular tracer of vascular permeability and the transferrin receptor. J Nucl Med 30: 1676-1685, 1989.
35. Parker JC. Inhibitors of myosin light chain kinase and phosphodiesterase reduce ventilator-induced lung injury. J Appl Physiol 89: 2241-2248, 2000.
36. Parker JC, Ivey CL, Tucker JA. Gadolinium prevents high airway pressure-induced permeability increases in isolated rat lungs. J Appl Physiol 84: 1113-1118, 1998.
37. Peterson BT, Dickerson KD, James HL, Miller EJ, McLarty JW, Holiday DB. Comparison of three tracers for detecting lung epithelial injury in anesthetized sheep. J Appl Physiol 66: 2374-2383, 1989.
38. Peterson BT, James HL, McLarty JW. Effects of lung volume on clearance of solutes from the air spaces of lungs. J Appl Physiol 64: 1068-1075, 1988.
39. Ragette R, Fu C, Bhattacharya J. Barrier effects of hyperosmolar signaling in microvascular endothelium of rat lung. J Clin Invest 100: 685-692, 1997.
40. Riggs DS. Transfer of substances between biological compartments. General kinetics. In: The Mathematical Approach to Physiological Problems, edited by Press TM. Baltimore, MD: Williams and Wilkins, 1972, p. 193-220.
41. Roselli RJ, Riddle WR. Analysis of noninvasive macromolecular transport measurements in the lung. J Appl Physiol 67: 2343-2350, 1989.
42. Safdar Z, Wang P, Ichimura H, Issekutz AC, Quadri S, Bhattacharya J. Hyperosmolarity enhances the lung capillary barrier. J Clin Invest 112: 1541-1549, 2003.
43. Saumon G, Basset G. Electrolyte and fluid transport across the mature alveolar epithelium. J Appl Physiol 74: 1-15, 1993.
44. Saumon G, Martet G, Loiseau P. Glucose transport and equilibrium across alveolar-airway barrier of rat. Am J Physiol Lung Cell Mol Physiol 270: L183-L190, 1996.
45. Schuster DP, Markham J, Welch MJ. Positron emission tomography measurements of pulmonary vascular permeability with Ga-68 transferrin or C-11 methylalbumin. Crit Care Med 26: 518-525, 1998.
46. Staub NC. Pulmonary edema. Physiol Rev 54: 678-811, 1974.
47. Sugerman HJ, Hirsch JI, Strash AM, Kan PT, Sharpe AR Jr, Stoneburner J, Greenfield LJ. Preliminary report Gamma camera detection of oleic acid alveolar-capillary albumin leak. J Surg Res 29: 93-99, 1980.
48. Sugerman HJ, Strash AM, Hirsch JI, Shirazi KL, Tatum JL, Mathers JA, Greenfield LJ. Scintigraphy and radiography in oleic acid pulmonary microvascular injury: effects of positive end-expiratory pressure (PEEP). J Trauma 22: 179-185, 1982.
49. Tatum JL, Strash AM, Sugerman HJ, Hirsch JI, Beachley MC, Greenfield LJ. Single isotope evaluation of pulmonary capillary protein leak (ARDS model) using computerized gamma scintigraphy. Invest Radiol 16: 473-478, 1981.
50. 99mTc-human serum albumin clearance and effects of surfactant replacement after lung lavage in rabbits. Crit Care Med 24: 1518-1523, 1996.
51. Vlahakis NE, Hubmayr RD. Cellular stress failure in ventilator-injured lungs. Am J Respir Crit Care Med 171: 1328-1342, 2005.
52. Vlahakis NE, Schroeder MA, Pagano RE, Hubmayr RD. Deformation-induced lipid trafficking in alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol 280: L938-L946, 2001.
53. Ware LB, Matthay MA. Alveolar fluid clearance is impaired in the majority of patients with acute lung injury and the acute respiratory distress syndrome. Am J Respir Crit Care Med 163: 1376-1383, 2001.
54. Wiener-Kronish JP, Albertine KH, Matthay MA. Differential responses of the endothelial and epithelial barriers of the lung in sheep to Escherichia coli endotoxin. J Clin Invest 88: 864-875, 1991.