Case 4-2007: A 56-year-old woman with rapidly progressive vertigo and ataxia

New England Journal of Medicine

Volumn 356, Issue 6, 2007, Pages 612-

  Dalmau, Josep ^a   Gonzalez, R Gilberto ^b,c   Lerwill, Melinda F ^b,c  

^a HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIEMETIC AGENT; CORTICOSTEROID; IMMUNOGLOBULIN; NAVELBINE; TRASTUZUMAB; WARFARIN; ANTIBODY; CDR2 PROTEIN, HUMAN; NERVE PROTEIN; UNCLASSIFIED DRUG;

ADULT; ANAMNESIS; ARTICLE; ATAXIA; BREAST CANCER; CASE REPORT; CENTRAL NERVOUS SYSTEM; CEREBELLUM DEGENERATION; CEREBROSPINAL FLUID; CLINICAL FEATURE; COMPUTER ASSISTED TOMOGRAPHY; DEMYELINATING DISEASE; DIAGNOSTIC PROCEDURE; DIFFERENTIAL DIAGNOSIS; FEMALE; HOSPITAL ADMISSION; HUMAN; IMMUNOASSAY; LABORATORY TEST; NEUROIMAGING; NEUROLOGIC DISEASE; NEUROLOGIC EXAMINATION; NUCLEAR MAGNETIC RESONANCE IMAGING; PARANEOPLASTIC NEUROPATHY; PARANEOPLASTIC SYNDROME; PHYSICAL EXAMINATION; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; SARCOIDOSIS; STROKE; VERTEBRAL ARTERY; VERTIGO; VOMITING; AXILLA; BIOPSY; BLOOD; BREAST DISEASE; BREAST TUMOR; CARCINOMA; CEREBELLUM; CLINICAL OBSERVATION; CLINICAL STUDY; DIAGNOSIS; IMMUNOLOGY; LYMPH NODE; LYMPH NODE METASTASIS; METASTASIS; MIDDLE AGED; PATHOLOGY;

ANTIBODIES; ATAXIA; AXILLA; BIOPSY; BREAST DISEASES; BREAST NEOPLASMS; CARCINOMA; CEREBELLUM; DIAGNOSIS, DIFFERENTIAL; FEMALE; HUMANS; LYMPH NODES; LYMPHATIC METASTASIS; MAGNETIC RESONANCE IMAGING; MIDDLE AGED; NERVE TISSUE PROTEINS; PARANEOPLASTIC CEREBELLAR DEGENERATION; VERTIGO;

EID: 33846887166     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMcpc069035     Document Type: Article

References (33)

1. Glaspy JA. Hemostatic abnormalities in multiple myeloma and related disorders. Hematol Oncol Clin North Am 1992;6:1301-14.
2. Whitaker JN, Lisak RP, Bashir RM, et al. Immunoreactive myelin basic protein in the cerebrospinal fluid in neurological disorders. Ann Neurol 1980;7:58-64.
3. Sharma OP. Neurosarcoidosis: a personal perspective based on the study of 37 patients. Chest 1997;112:220-8.
4. Baehring JM, Longtine J, Hochberg FH. A new approach to the diagnosis and treatment of intravascular lymphoma. J Neurooncol 2003;61:237-48.
5. McGuigan C, Bigham S, Johnston D, Hart PE. Encephalopathy in a patient with previous malignancy but normal brain imaging. Neurology 2005;65:165.
6. Bataller L, Dalmau JO. Paraneoplastic disorders of the central nervous system: update on diagnostic criteria and treatment. Semin Neurol 2004;24:461-71.
7. Graus F, Delattre JY, Antoine JC, et al. Recommended diagnostic criteria for paraneoplastic neurological syndromes. J Neurol Neurosurg Psychiatry 2004;75:1135-40.
8. Darnell RB. Paraneoplastic neurologic disorders: windows into neuronal function and tumor immunity. Arch Neurol 2004;61:30-2.
9. Younes-Mhenni S, Janier MF, Cinotti L, et al. FDG-PET improves tumour detection in patients with paraneoplastic neurological syndromes. Brain 2004;127:2331-8.
10. Sommer C, Weishaupt A, Brinkhoff J, et al. Paraneoplastic stiff-person syndrome: passive transfer to rats by means of IgG antibodies to amphiphysin. Lancet 2005;365:1406-11.
11. Rousseau A, Benyahia B, Dalmau J, et al. T cell response to Hu-D peptides in patients with anti-Hu syndrome. J Neurooncol 2005;71:231-6.
12. Albert ML, Austin LM, Darnell RB. Detection and treatment of activated T cells in the cerebrospinal fluid of patients with paraneoplastic cerebellar degeneration. Ann Neurol 2000;47:9-17.
13. Mason WP, Graus F, Lang B, et al. Small-cell lung cancer, paraneoplastic cerebellar degeneration and the Lambert-Eaton myasthenic syndrome. Brain 1997;120:1279-300.
14. Peterson K, Rosenblum MK, Kotanides H, Posner JB. Paraneoplastic cerebellar degeneration. I. A clinical analysis of 55 anti-Yo antibody-positive patients. Neurology 1992;42:1931-7.
15. Verschuuren J, Chuang L, Rosenblum MK, et al. Inflammatory infiltrates and complete absence of Purkinje cells in anti-Yo-associated paraneoplastic cerebellar degeneration. Acta Neuropathol (Berl) 1996;91:519-25.
16. Rojas-Marcos I, Rousseau A, Keime-Guibert F, et al. Spectrum of paraneoplastic neurologic disorders in women with breast and gynecologic cancer. Medicine (Baltimore) 2003;82:216-23.
17. Shams'ili S, Grefkens J, de Leeuw B, et al. Paraneoplastic cerebellar degeneration associated with antineuronal antibodies: analysis of 50 patients. Brain 2003;126:1409-18.
18. Bernal F, Shams'ili S, Rojas I, et al. Anti-Tr antibodies as markers of paraneoplastic cerebellar degeneration and Hodgkin's disease. Neurology 2003;60:230-4.
19. Sillevis Smitt P, Kinoshita A, De Leeuw B, et al. Paraneoplastic cerebellar ataxia due to autoantibodies against a glutamate receptor. N Engl J Med 2000;342:21-7.
20. Ances BM, Vitaliani R, Taylor RA, et al. Treatment-responsive limbic encephalitis identified by neuropil antibodies: MRI and PET correlates. Brain 2005;128:1764-77.
21. El-Wakeel H, Umpleby HC. Systematic review of fibroadenoma as a risk factor for breast cancer. Breast 2003;12:302-7.
22. Chiang SB, Rebenstock A, Guan L, Burns J, Alavi A, Zhuang H. Potential false-positive FDG PET imaging caused by subcutaneous radiotracer infiltration. Clin Nucl Med 2003;28:786-8.
23. Dalmau J, Graus F, Rosenblum MK, Posner JB. Anti-Hu-associated paraneoplastic encephalomyelitis/sensory neuronopathy: a clinical study of 71 patients. Medicine (Baltimore) 1992;71:59-72.
24. Graus F, Lang B, Pozo-Rosich P, Saiz A, Casamitjana R, Vincent A. P/Q type calcium-channel antibodies in paraneoplastic cerebellar degeneration with lung cancer. Neurology 2002;59:764-6.
25. Clouston PD, Saper CB, Arbizu T, et al. Paraneoplastic cerebellar degeneration. III. Cerebellar degeneration, cancer, and the Lambert-Eaton myasthenic syndrome. Neurology 1992;42:1944-50.
26. Lerwill MF. Current practical applications of diagnostic immunohistochemistry in breast pathology. Am J Surg Pathol 2004;28:1076-91.
27. Rosen PP. Rosen's breast pathology. 2nd ed. Philadelphia: Lippincott Williams & Wilkins, 2001.
28. Galimberti V, Bassani G, Monti S, et al. Clinical experience with axillary presentation breast cancer. Breast Cancer Res Treat 2004;88:43-7.
29. Haupt HM, Rosen PP, Kinne DW. Breast carcinoma presenting with axillary lymph node metastases: an analysis of specific histopathologic features. Am J Surg Pathol 1985;9:165-75.
30. Schmahmann JD, Sherman JC. The cerebellar cognitive affective syndrome. Brain 1998;121:561-79.
31. Mathew RM, Cohen AB, Galetta SL, Alavi A, Dalmau J. Paraneoplastic cerebellar degeneration: Yo-expressing tumor revealed after a 5-year follow-up with FDGPET. J Neurol Sci 2006;250:153-5.
32. Darnell RB, Posner JB. Paraneoplastic syndromes involving the nervous system. N Engl J Med 2003;349:1543-54.
33. Okano HJ, Park W-Y, Corradi JP, Darnell RB. The cytoplasmic Purkinje onconeural antigen cdr2 down-regulates c-Myc function: implications for neuronal and tumor cell survival. Genes Dev 1999;13:2087-97.