Interleukin-6 does/does not have a beneficial role in insulin sensitivity and glucose homeostasis [5]

Journal of Applied Physiology

Volumn 102, Issue 2, 2007, Pages 821-822

  Bastard, Jean Philippe ^a   Lagathu, Claire ^a   Caron, Martine ^a   Capeau, Jacqueline ^a  

^a INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; INTERLEUKIN 1; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA; GLUCOSE;

ADIPOSE TISSUE; CYTOKINE PRODUCTION; HUMAN; INSULIN RESISTANCE; INSULIN SENSITIVITY; LETTER; MACROPHAGE MIGRATION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; WEIGHT REDUCTION; ANIMAL; GENETICS; HOMEOSTASIS; LIVER; METABOLISM; MOUSE; MOUSE MUTANT; NOTE; PHYSIOLOGY;

ADIPOSE TISSUE; ANIMALS; GLUCOSE; HOMEOSTASIS; HUMANS; INSULIN; INSULIN RESISTANCE; INTERLEUKIN-6; LIVER; MICE; MICE, KNOCKOUT; TUMOR NECROSIS FACTOR-ALPHA;

EID: 33846878960     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.01353.2006     Document Type: Letter

References (6)

1. Al-Khalili L, Bouzakri K, Glund S, Lonnqvist F, Koistinen HA, Krook A. Signaling specificity of interleukin-6 action on glucose and lipid metabolism in skeletal muscle. Mol Endocrinol. In press.
2. Bruun JM, Lihn AS, Verdich C, Pedersen SB, Toubro S, Astrup A, Bjørn Richelsen B. Regulation of adiponectin by adipose tissue-derived cytokines: in vivo and in vitro investigations in humans. Am J Physiol Endocrinol Metab 285: E527-533, 2003.
3. Cancello R, Henegar C, Viguerie N, Taleb S, Poitou C, Rouault C, Coupaye M, Pelloux V, Hugol D, Bouillot JL, Bouloumié A, Barbatelli G, Cinti S, Svensson PA, Barsh GS, Zucker JD, Basdevant A, Langin D, Clément K. Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss. Diabetes 54: 2277-2286, 2005.
4. Lagathu C, Bastard JP, Auclair M, Maachi M, Capeau J, Caron M. Chronic interleukin-6 (IL-6) treatment increased IL-6 secretion and induced insulin resistance in adipocyte: prevention by rosiglitazone. Biochem Biophys Res Commun 311: 372-379, 2003.
5. Mooney RA. Counterpoint: Interleukin-6 does not have a beneficial role in insulin sensitivity and glucose homeostasis. J Appl Physiol. In press.
6. Pedersen BK, Febbraio MA. Point: Interleukin-6 does have a beneficial role in insulin sensitivity and glucose homeostasis. J Appl Physiol. In press.