Regulation of proteolysis and optimal protein accretion in extremely premature newborns

American Journal of Clinical Nutrition

Volumn 85, Issue 2, 2007, Pages

  Denne, Scott C ^a  

^a INDIANA UNIVERSITY   (United States)

Author keywords

Growth; Leucine; Phenylalanine; Premature infants; Protein accretion; Proteolysis; Stable isotope tracers

Indexed keywords

AMINO ACID; INSULIN; LEUCINE; PHENYLALANINE; STABLE ISOTOPE;

CONFERENCE PAPER; ENTERIC FEEDING; HUMAN; MEDICAL RESEARCH; PARENTERAL NUTRITION; POSTNATAL GROWTH; PREMATURITY; PROTEIN CONTENT; PROTEIN DEGRADATION; PROTEIN SYNTHESIS;

EID: 33846867016     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/85.2.621s     Document Type: Conference Paper

References (24)

1. Lemons JA, Bauer CR, Oh W, et al. Very low birth weight outcomes of the National Institute of Child Health and Human Development Neonatal Research Network, January 1995 through December 1996. Pediatrics [serial online] 2001;107:e1. Internet: http://pediatrics.aappublications.org/cgi/content/full/ 107/1/e1 (accessed 16 December 2006).
2. Dusick AM, Poindexter BB, Ehrenkranz RA, Lemons JA. Growth failure in the preterm infant: can we catch up? Semin Perinatol 2003;27:302-10.
3. Clark RH, Thomas P, Peabody J. Extrauterine growth restriction remains a serious problem in prematurely born neonates. Pediatrics 2003;111:986-90.
4. Denne S, Liechty E, Liu Y, Brechtel G, Baron A. Proteolysis in skeletal muscle and whole body in response to euglycemic hyperinsulinemia in normal adults. Am J Physiol 1991;261:E809-14.
5. Robert JJ, Bier DM, Zhao XH, Matthews DE, Young VR. Glucose and insulin effects on the novo amino acid synthesis in young men: studies with stable isotope labeled alanine, glycine, leucine, and lysine. Metabolism 1982;31:1210-8.
6. Hertz DE, Karn CA, Liu YM, Liechty EA, Denne SC. Intravenous glucose suppresses glucose production but not proteolysis in extremely premature newborns. J Clin Invest 1993;92:1752-8.
7. Poindexter BB, Karn CA, Ahlrichs JA, et al. Amino acids suppress proteolysis independent of insulin throughout the neonatal period. Am J Physiol 1997;272:E592-9.
8. Poindexter BB, Karn CA, Leitch CA, Liechty EA, Denne SC. Amino acids do not suppress proteolysis in premature neonates. Am J Physiol Endocrinol Metab 2001;281:E472-8.
9. Denne SC, Karn CA, Ahlrichs JA, Dorotheo AR, Wang J, Liechty EA. Proteolysis and phenylalanine hydroxylation in response to parenteral nutrition in extremely premature and normal newborns. J Clin Invest 1996;97:746-54.
10. Clark SE, Karn CA, Ahlrichs JA, et al. Acute changes in leucine and phenylalanine kinetics produced by parenteral nutrition in premature infants. Pediatr Res 1997;41:568-74.
11. Poindexter BB, Karn CA, Denne SC. Exogenous insulin reduces proteolysis and protein synthesis in extremely low birth weight infants. J Pediatr 1998;132:948-53.
12. Christensen M, Helms R, Veal D, Boehm K, Storm M. Clearance of N-acetyl-L-tyrosine in infants receiving a pediatric amino acid solution. Clin Pharmacol 1993;12:606-9.
13. Kalhan SC, Parimi PS, Gruca LL, Hanson RW. Glutamine supplement with parenteral nutrition decreases whole body proteolysis in low birth weight infants. J Pediatr 2005;146:642-7.
14. Poindexter BB, Ehrenkranz RA, Stoll BJ, et al. Parenteral glutamine supplementation does not reduce the risk of mortality or late-onset sepsis in extremely low birth weight infants. Pediatrics 2004;113:1209-15.
15. Poindexter B, Wright-Coltart S, Denne SC. The effect of N-acetyl tyrosine and cysteine in parenteral nutrition on protein metabolism in extremely low birth weight neonates. Pediatr Res 2000;47:294A.
16. Rivera A, Bell EF, Bier DM. Effect of intravenous amino acids on protein metabolism of preterm infants during the first three days of life. Pediatr Res 1993;33:106-11.
17. Van Goudoever JB, Colen T, Wattimena JLD, Huijmans JGM, Carnielli VP, Sauer PJJ. Immediate commencement of amino acid supplementation in preterm infants: effect on serum amino acid concentrations and protein kinetics on the first day of life. J Pediatr 1995;127:458-65.
18. Thureen PJ, Melara D, Fennessey PV, Hay WW Jr. Effect of low versus high intravenous amino acid intake on very low birth weight infants in the early neonatal period. Pediatr Res 2003;53:24-32.
19. Poindexter BB, Langer JC, Dusick AM, Ehrenkranz RA. Early provision of parenteral amino acids in extremely low birth weight infants: relation to growth and neurodevelopmental outcome. J Pediatr 2006;148:300-5.
20. 15N]leucine kinetics in relation to enteral and parenteral amino acid supply. Am J Physiol Endocrinol Metab 1992;262:E687-94.
21. van der Schoor SR, Reeds PJ, Stellaard F, et al. Lysine kinetics in preterm infants: the importance of enteral feeding. Gut 2004;53:38-43.
22. Embleton NE, Pang N, Cooke RJ. Postnatal malnutrition and growth retardation: an inevitable consequence of current recommendations in preterm infants? Pediatrics 2001;107:270-3.
23. Zello GA, Menendez CE, Rafii M, et al. Minimum protein intake for the preterm neonate determined by protein and amino acid kinetics. Pediatr Res 2003;53:338-44.
24. Cooke R, Embleton N, Rigo J, Carrie A, Haschke F, Ziegler E. High protein pre-term infant formula: effect on nutrient balance, metabolic status and growth. Pediatr Res 2006;59:265-70.