메뉴 건너뛰기




Volumn 23, Issue 1, 2007, Pages 54-61

Changes in the peripheral blood mtDNA levels in naive patients treated by different nucleoside reverse transcriptase inhibitor combinations and their association with subsequent lipodystrophy

(173)  Chêne, Geneviève a,b   Amellal, Bahia c   Pédrono, Gaëlle a   Gourlain, Karine c   Rancinan, Corinne a   Journot, Valérie a   Cotte, Laurent d   Palmer, Pierre e   De Castro, Nathalie f   Calvez, Vincent c   Molina, Jean Michel e   Aboulker, J P ae   Decazes, J M e   Dormont, J ae   Dumon, B ae   Ferchal, F ae   Madelaine, I ae   Metro, A ae   Meyohas, M C f,ae   Modai J e   more..

a INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DIDANOSINE; LAMIVUDINE; MITOCHONDRIAL DNA; RNA DIRECTED DNA POLYMERASE INHIBITOR; STAVUDINE; ZIDOVUDINE;

EID: 33846844983     PISSN: 08892229     EISSN: None     Source Type: Journal    
DOI: 10.1089/aid.2006.0039     Document Type: Article
Times cited : (10)

References (35)
  • 1
    • 0033604038 scopus 로고    scopus 로고
    • Mitochondrial toxicity induced by nucleoside-analogue reverse-trasncriptase inhibitors is a key factor in the pathogenesis of antiretroviral-therapy related lipodystrophy
    • Brinkrnan K, Smeitink JA, Romijn JA, and Reiss P: Mitochondrial toxicity induced by nucleoside-analogue reverse-trasncriptase inhibitors is a key factor in the pathogenesis of antiretroviral-therapy related lipodystrophy. Lancet 1999;354:1112-1115.
    • (1999) Lancet , vol.354 , pp. 1112-1115
    • Brinkrnan, K.1    Smeitink, J.A.2    Romijn, J.A.3    Reiss, P.4
  • 2
    • 0034008520 scopus 로고    scopus 로고
    • A syndrome of lipoatrophy, lactic acidaemia and liver dysfunction associated with HIV nucleoside analogue therapy: Contribution to protease inhibitor-related lipodystrophy syndrome
    • Carr A, Miller J, Law M, and Cooper DA: A syndrome of lipoatrophy, lactic acidaemia and liver dysfunction associated with HIV nucleoside analogue therapy: Contribution to protease inhibitor-related lipodystrophy syndrome. AIDS 2000;14:F25-F32.
    • (2000) AIDS , vol.14
    • Carr, A.1    Miller, J.2    Law, M.3    Cooper, D.A.4
  • 3
    • 0033924871 scopus 로고    scopus 로고
    • Contribution of nucleoside analogue reverse transcriptase inhibitors to subcutaneous fat wasting in patients with HIV infection
    • Mallal SA, John M, Moore CB, James IR, and McKinnon EJ: Contribution of nucleoside analogue reverse transcriptase inhibitors to subcutaneous fat wasting in patients with HIV infection. AIDS 2000;14:1309-1316.
    • (2000) AIDS , vol.14 , pp. 1309-1316
    • Mallal, S.A.1    John, M.2    Moore, C.B.3    James, I.R.4    McKinnon, E.J.5
  • 4
    • 2342589533 scopus 로고    scopus 로고
    • Reversibility of lipoatrophy in HIV-infected patients 2 years after switching from a thymidine analogue to abacavir: The MITOX extension study
    • Martin A, Smith D, Carr A, Ringland C, Amin J, et al.: Reversibility of lipoatrophy in HIV-infected patients 2 years after switching from a thymidine analogue to abacavir: The MITOX extension study. AIDS 2004;18:1029-1036.
    • (2004) AIDS , vol.18 , pp. 1029-1036
    • Martin, A.1    Smith, D.2    Carr, A.3    Ringland, C.4    Amin, J.5
  • 5
    • 0037032941 scopus 로고    scopus 로고
    • Increased risk of lipoatrophy under stavudine in HIV-1-infected patients: Results of a substudy from a comparative trial
    • Joly V, Flandre P, Meiffredy V, et al.: Increased risk of lipoatrophy under stavudine in HIV-1-infected patients: Results of a substudy from a comparative trial. AIDS 2002;16:2447-2454.
    • (2002) AIDS , vol.16 , pp. 2447-2454
    • Joly, V.1    Flandre, P.2    Meiffredy, V.3
  • 6
    • 0035964717 scopus 로고    scopus 로고
    • Mitochondrial DNA decrease in subcutaneous adipose tissue on HIV-infected individuals with peripheral lipoatrophy
    • Shikuma C, Hu M, Milne C, Yost F, Waslien C, and Shimizu S: Mitochondrial DNA decrease in subcutaneous adipose tissue on HIV-infected individuals with peripheral lipoatrophy. AIDS 2001;15:1801-1809.
    • (2001) AIDS , vol.15 , pp. 1801-1809
    • Shikuma, C.1    Hu, M.2    Milne, C.3    Yost, F.4    Waslien, C.5    Shimizu, S.6
  • 7
    • 0037999080 scopus 로고    scopus 로고
    • Mitochondrial DNA depletion and morphologic changes in adipocytes associated with nucleoside reverse transcriptase inhibitor therapy
    • Nolan D, Hammond E, Martin A, et al.: Mitochondrial DNA depletion and morphologic changes in adipocytes associated with nucleoside reverse transcriptase inhibitor therapy. AIDS 2003;17:1329-1338.
    • (2003) AIDS , vol.17 , pp. 1329-1338
    • Nolan, D.1    Hammond, E.2    Martin, A.3
  • 9
    • 10744226254 scopus 로고    scopus 로고
    • Mitochondrial DNA depletion and respiratory chain enzyme deficiencies present in peripheral blood mononuclear cells of HIV-infected patients HAART-related lipodystrophy
    • Miro O, Lopez S, Pedrol E, et al.: Mitochondrial DNA depletion and respiratory chain enzyme deficiencies present in peripheral blood mononuclear cells of HIV-infected patients HAART-related lipodystrophy. Antiviral Ther 2003;8:333-338.
    • (2003) Antiviral Ther , vol.8 , pp. 333-338
    • Miro, O.1    Lopez, S.2    Pedrol, E.3
  • 10
    • 0034854715 scopus 로고    scopus 로고
    • Quantification of mitochondrial DNA in peripheral blood mononuclear cells and subcutaneous fat using real-time polymerase chain reaction
    • Gahan M, Miller F, and Lewin S: Quantification of mitochondrial DNA in peripheral blood mononuclear cells and subcutaneous fat using real-time polymerase chain reaction. J Clin Virol 2001;22:241-247.
    • (2001) J Clin Virol , vol.22 , pp. 241-247
    • Gahan, M.1    Miller, F.2    Lewin, S.3
  • 11
    • 1242341437 scopus 로고    scopus 로고
    • Greater and more rapid depletion of mitochondrial DNA in blood of patients treated with dual (zidovudine + didanosine or zidovudine + zalcitabine) vs. single (zidovudine) nucleoside reverse transcriptase inhibitors
    • Reiss P, Casula M, de Ronde A, Weverling G, Goudsmit J, and Lange J: Greater and more rapid depletion of mitochondrial DNA in blood of patients treated with dual (zidovudine + didanosine or zidovudine + zalcitabine) vs. single (zidovudine) nucleoside reverse transcriptase inhibitors. HW Med 2004;5:11-14.
    • (2004) HW Med , vol.5 , pp. 11-14
    • Reiss, P.1    Casula, M.2    de Ronde, A.3    Weverling, G.4    Goudsmit, J.5    Lange, J.6
  • 12
    • 0033502897 scopus 로고    scopus 로고
    • The ALBI trial: A randomized controlled trial comparing stavudine plus didanosine with zidovudine plus lamivudine and a regimen alternating both combinations in previously untreated patients infected with human immunodeficiency virus
    • Molina J, Chêne G, Ferchal F, et al.: The ALBI trial: A randomized controlled trial comparing stavudine plus didanosine with zidovudine plus lamivudine and a regimen alternating both combinations in previously untreated patients infected with human immunodeficiency virus. J Infect Dis 1999;180:351-358.
    • (1999) J Infect Dis , vol.180 , pp. 351-358
    • Molina, J.1    Chêne, G.2    Ferchal, F.3
  • 13
    • 0036499058 scopus 로고    scopus 로고
    • Role of long-term nucleoside-analogue therapy in lipodystrophy and metabolic disorders in human immunodeficiency virus-infected patients
    • Chêne G, Angelini E, Cotte L, et al.: Role of long-term nucleoside-analogue therapy in lipodystrophy and metabolic disorders in human immunodeficiency virus-infected patients. Clin Infect Dis 2002;34:649-657.
    • (2002) Clin Infect Dis , vol.34 , pp. 649-657
    • Chêne, G.1    Angelini, E.2    Cotte, L.3
  • 14
    • 0031790955 scopus 로고    scopus 로고
    • Novel approach to quantitative polymerase chain reaction using real-time detection: Application to the detection of gene amplification in breast cancer
    • Bieche, Olivi M, Champeme M, Vidaud D, Lidereau R, and Vidaud M: Novel approach to quantitative polymerase chain reaction using real-time detection: Application to the detection of gene amplification in breast cancer. Int J Cancer 1998;78:661-666.
    • (1998) Int J Cancer , vol.78 , pp. 661-666
    • Bieche1    Olivi, M.2    Champeme, M.3    Vidaud, D.4    Lidereau, R.5    Vidaud, M.6
  • 15
  • 16
    • 0037076029 scopus 로고    scopus 로고
    • Changes in mitochondrial DNA as a marker of nucleoside toxicity in HIV-infected patients
    • Côté H, Brumme Z, Craib K, Alexander C, Wynhoven B, and Ting L: Changes in mitochondrial DNA as a marker of nucleoside toxicity in HIV-infected patients. N Engl J Med 2002;346:811-820.
    • (2002) N Engl J Med , vol.346 , pp. 811-820
    • Côté, H.1    Brumme, Z.2    Craib, K.3    Alexander, C.4    Wynhoven, B.5    Ting, L.6
  • 17
    • 10744222741 scopus 로고    scopus 로고
    • Depletion of mitochondrial DNA in liver under antiretroviral therapy: Didanosine, stavudine, or zalcitabine
    • Walker U, Bauerle J, Laguno M, et al.: Depletion of mitochondrial DNA in liver under antiretroviral therapy: Didanosine, stavudine, or zalcitabine. Hepatology 2004;39:311-317.
    • (2004) Hepatology , vol.39 , pp. 311-317
    • Walker, U.1    Bauerle, J.2    Laguno, M.3
  • 18
    • 0031003145 scopus 로고    scopus 로고
    • Cellular and mitochondrial toxicity of zidovudine (AZT), didanosine (ddI) and zalcitabine (ddC) on cultured human muscle cells
    • Benbrik E, Chariot P, Bonavaud S, et al.: Cellular and mitochondrial toxicity of zidovudine (AZT), didanosine (ddI) and zalcitabine (ddC) on cultured human muscle cells. J Neurol Sci 1997;149:19-25.
    • (1997) J Neurol Sci , vol.149 , pp. 19-25
    • Benbrik, E.1    Chariot, P.2    Bonavaud, S.3
  • 19
    • 0038010608 scopus 로고    scopus 로고
    • Mitochondrial-nuclear DNA ratios in peripheral blood cells from human immunodeficiency virus (HIV)-infected patients who received selected antiretroviral drug regimens
    • Côté H, Yip B, Asselin J, et al.: Mitochondrial-nuclear DNA ratios in peripheral blood cells from human immunodeficiency virus (HIV)-infected patients who received selected antiretroviral drug regimens. J Infect Dis 2003;187:1972-1976.
    • (2003) J Infect Dis , vol.187 , pp. 1972-1976
    • Côté, H.1    Yip, B.2    Asselin, J.3
  • 20
    • 0037055028 scopus 로고    scopus 로고
    • Abacavir substitution for nucleoside analogs in patients with HIV lipoatrophy. A randomized trial
    • Carr A, Workman C, Smith D, et al.: Abacavir substitution for nucleoside analogs in patients with HIV lipoatrophy. A randomized trial. JAMA 2002;288:207-215.
    • (2002) JAMA , vol.288 , pp. 207-215
    • Carr, A.1    Workman, C.2    Smith, D.3
  • 21
    • 0029030096 scopus 로고
    • Nucleoside analogue-associated peripheral neuropathy in HIV-infection
    • Simpson D and Tagliati M: Nucleoside analogue-associated peripheral neuropathy in HIV-infection. J Acquir Immune Defic Syndr 1995;9:153-161.
    • (1995) J Acquir Immune Defic Syndr , vol.9 , pp. 153-161
    • Simpson, D.1    Tagliati, M.2
  • 22
    • 4544253103 scopus 로고    scopus 로고
    • Mitochondrial effects of antiretroviral therapies in asymptomatic patients
    • Lopez S, Miro O, Martinez E, et al.: Mitochondrial effects of antiretroviral therapies in asymptomatic patients. Antiviral Ther 2004;9:47-55.
    • (2004) Antiviral Ther , vol.9 , pp. 47-55
    • Lopez, S.1    Miro, O.2    Martinez, E.3
  • 23
    • 27744470085 scopus 로고    scopus 로고
    • Mitochondrial DNA and RNA increase in peripheral blood mononuclear cells from HIV-1-infected patients randomized to receive stavudine-containing or stavudine-sparing combination therapy
    • Casula M, Weverling GJ, Wit FW, et al.: Mitochondrial DNA and RNA increase in peripheral blood mononuclear cells from HIV-1-infected patients randomized to receive stavudine-containing or stavudine-sparing combination therapy. J Infect Dis 2005;192:1794-1800.
    • (2005) J Infect Dis , vol.192 , pp. 1794-1800
    • Casula, M.1    Weverling, G.J.2    Wit, F.W.3
  • 24
    • 0042911524 scopus 로고    scopus 로고
    • Increased mitochondrial DNA content in peripheral blood lymphocytes from HIV-infected patients with lipodystrophy
    • Cossarizza A, Riva A, Pinti M, et al.: Increased mitochondrial DNA content in peripheral blood lymphocytes from HIV-infected patients with lipodystrophy. Antiviral Ther 2003;8:315-321.
    • (2003) Antiviral Ther , vol.8 , pp. 315-321
    • Cossarizza, A.1    Riva, A.2    Pinti, M.3
  • 25
    • 17644397505 scopus 로고    scopus 로고
    • Infection with HIV-1 induces a decrease in mtDNA
    • Casula M, Bosboom-Dobbelaer I, Smolders K, et al.: Infection with HIV-1 induces a decrease in mtDNA. J Infect Dis 2005;191:1468-1471.
    • (2005) J Infect Dis , vol.191 , pp. 1468-1471
    • Casula, M.1    Bosboom-Dobbelaer, I.2    Smolders, K.3
  • 26
    • 1842502612 scopus 로고    scopus 로고
    • Changes in mitochoondiral DNA copy number in blood cells from HIV-infected pateints undergoing antiretroviral therapy
    • de Mendoza C, de Ronde A, Smolders K, et al.: Changes in mitochoondiral DNA copy number in blood cells from HIV-infected pateints undergoing antiretroviral therapy. AIDS Res Hum Retroviruses 2004;20:271-273.
    • (2004) AIDS Res Hum Retroviruses , vol.20 , pp. 271-273
    • de Mendoza, C.1    de Ronde, A.2    Smolders, K.3
  • 27
    • 20844453407 scopus 로고    scopus 로고
    • Mitochondrial effects of HIV infection on the peripheral blood mononuclear cells of HIV-infected patients who were never treated with antiretrovirals
    • Miro O, Lopez S, Martinez E, et al.: Mitochondrial effects of HIV infection on the peripheral blood mononuclear cells of HIV-infected patients who were never treated with antiretrovirals. Clin Infect Dis 2004;39:710-716.
    • (2004) Clin Infect Dis , vol.39 , pp. 710-716
    • Miro, O.1    Lopez, S.2    Martinez, E.3
  • 28
    • 3943095878 scopus 로고    scopus 로고
    • Changes in mitochondrial DNA in peripheral blood mononuclear cells from HIV-infected patients with lipoatrophy randomized to receive abacavir
    • Hoy J, Gahan M, Carr A, et al.: Changes in mitochondrial DNA in peripheral blood mononuclear cells from HIV-infected patients with lipoatrophy randomized to receive abacavir. J Infect Dis 2004;190:688-692.
    • (2004) J Infect Dis , vol.190 , pp. 688-692
    • Hoy, J.1    Gahan, M.2    Carr, A.3
  • 29
    • 19944426227 scopus 로고    scopus 로고
    • Improvements in lipoatrophy, mitochondrial DNA levels and fat apoptosis after replacing stavudine with abacavir or zidovudine
    • McComsey GA, Paulsen DM, Lonergan JT, et al.: Improvements in lipoatrophy, mitochondrial DNA levels and fat apoptosis after replacing stavudine with abacavir or zidovudine. AIDS 2005;19:15-23.
    • (2005) AIDS , vol.19 , pp. 15-23
    • McComsey, G.A.1    Paulsen, D.M.2    Lonergan, J.T.3
  • 30
    • 27744498063 scopus 로고    scopus 로고
    • Reductions in stavudine dose might ameliorate mitochondrial-associated complications without compromising antiviral activity
    • Sanchez-Conde M, de Mendoza C, Jimenez-Nacher I, Barreiro P, Gonzalez-Lahoz J, and Soriano V. Reductions in stavudine dose might ameliorate mitochondrial-associated complications without compromising antiviral activity. HIV Clin Trials 2005;6:197-202.
    • (2005) HIV Clin Trials , vol.6 , pp. 197-202
    • Sanchez-Conde, M.1    de Mendoza, C.2    Jimenez-Nacher, I.3    Barreiro, P.4    Gonzalez-Lahoz, J.5    Soriano, V.6
  • 31
    • 27144527399 scopus 로고    scopus 로고
    • Effect of treatment interruption monitored by CD4 cell count on mitochondrial DNA content in HIV-infected patients: A prospective study
    • Mussini C, Pinti M, Bugarini R, et al.: Effect of treatment interruption monitored by CD4 cell count on mitochondrial DNA content in HIV-infected patients: A prospective study. AIDS 2005;19:1627-1633.
    • (2005) AIDS , vol.19 , pp. 1627-1633
    • Mussini, C.1    Pinti, M.2    Bugarini, R.3
  • 32
    • 0033391005 scopus 로고    scopus 로고
    • A syndrome of peripheral fat wasting (lipodystrophy) in patients receiving long-term nucleoside analogue therapy
    • Saint-Marc T, Partisani M, Poizot-Martin I, et al.: A syndrome of peripheral fat wasting (lipodystrophy) in patients receiving long-term nucleoside analogue therapy. AIDS 1999;13:1659-1667.
    • (1999) AIDS , vol.13 , pp. 1659-1667
    • Saint-Marc, T.1    Partisani, M.2    Poizot-Martin, I.3
  • 33
    • 0037333717 scopus 로고    scopus 로고
    • An objective case definition of lipodystrophy in HIV-infected adults: A case-control study
    • HIV Lipodystrophy Case Definition Study Group
    • HIV Lipodystrophy Case Definition Study Group: An objective case definition of lipodystrophy in HIV-infected adults: A case-control study. Lancet 2003;361:726-735.
    • (2003) Lancet , vol.361 , pp. 726-735
  • 34
    • 3042734983 scopus 로고    scopus 로고
    • Prevalence of lipoatrophy and mitochondrial DNA content of blood and subcutaneous fat in HIV-1-infected patients randomly allocated to zidovudine- or stavudine-based therapy
    • Van der Valk M, Casula M, Weverling G, et al.: Prevalence of lipoatrophy and mitochondrial DNA content of blood and subcutaneous fat in HIV-1-infected patients randomly allocated to zidovudine- or stavudine-based therapy. Antiviral Ther 2004;9:385-393.
    • (2004) Antiviral Ther , vol.9 , pp. 385-393
    • Van der Valk, M.1    Casula, M.2    Weverling, G.3
  • 35
    • 7644244886 scopus 로고    scopus 로고
    • Mitochondrial DNA levels in fat and blood cells from patients with lipodystrophy or peripheral neuropathy and the effect of 90 days of high-dose coenzyme Q treatment: A randomized, double-blind, placebo-controlled pilot study
    • Rabing Christensen R, Stegger M, Jensen-Fangel S, Laursen A, and Ostergaard L: Mitochondrial DNA levels in fat and blood cells from patients with lipodystrophy or peripheral neuropathy and the effect of 90 days of high-dose coenzyme Q treatment: A randomized, double-blind, placebo-controlled pilot study. Clin Infect Dis 2004;39:1371-1379.
    • (2004) Clin Infect Dis , vol.39 , pp. 1371-1379
    • Rabing Christensen, R.1    Stegger, M.2    Jensen-Fangel, S.3    Laursen, A.4    Ostergaard, L.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.