Characterization of silicone elastomer vaginal rings containing HIV microbicide TMC120 by Raman spectroscopy

Journal of Pharmacy and Pharmacology

Volumn 59, Issue 2, 2007, Pages 203-207

  Bell, Steven E J ^a   Dennis, Andrew C ^b   Fido, Louise A ^b   Malcolm, R Karl ^a   Sirimuthu, Narayana M S ^a   Toner, Clare F ^a   Woolfson, A David ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b Avalon Instruments Ltd   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DAPIVIRINE; SILASTIC;

ARTICLE; DRUG DETERMINATION; DRUG MANUFACTURE; DRUG SOLUBILITY; DRUG STRUCTURE; RAMAN SPECTROMETRY; ROOM TEMPERATURE; VAGINA RING;

ANTI-HIV AGENTS; CONTRACEPTIVE DEVICES, FEMALE; DOSAGE FORMS; PYRIMIDINES; SILICONE ELASTOMERS; SOLUBILITY; SPECTRUM ANALYSIS, RAMAN;

EID: 33846840885     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp.59.2.0007     Document Type: Article

References (6)

1. Bell, S. E. J., Burns, D. T., Dennis, A. C., Speers, S. J. (2000) Rapid analysis of ecstasy and related phenethylamines in seized tablets by Raman spectroscopy. Analyst 125: 541-544
2. Bell, S. E. J., Beattie, J. R., McGarvey, J. J., Peters, K. L., Sirimuthu, N. M. S., Speers, S. J. (2004) Development of sampling methods for Raman analysis of solid dosage forms of therapeutic and illicit drugs. J. Raman Spectrosc. 35: 409-417
3. Clarke, F. C., Jamieson, M. J., Clark, D. A., Hammond, S. V., Jee, R. D., Moffat, A. C. (2001) Chemical image fusion. The synergy of FT-NIR and Raman mapping microscopy to enable a more complete visualization of pharmaceutical formulations. Anal. Chem. 73: 2213-2220
4. Malcolm, R. K., Woolfson, A. D., Toner, C. F. , Lowry, D. (2004) Vaginal microbicides for the prevention of HIV transmission. Biotech. Genetic Eng. Rev. 21: 81-122
5. Malcolm, R. K., Woolfson, A. D., Toner, C. F., Morrow, R. J., McCullagh, S. D. (2005) Long-term, controlled release of the HIV microbicide TMC120 from silicone elastomer vaginal rings. J. Antimicrob. Chemother. 56: 954-956
6. Williams, A. C. (2001) Some pharmaceutical applications of Raman spectroscopy. In: Lewis, I. R., Edwards, H. G. M. (eds) Handbook of raman spectroscopy. Marcel Dekker, New York, pp 575-591