Chlorpromazine and apigenin reduce adenovirus replication and decrease replication associated toxicity

Journal of Gene Medicine

Volumn 9, Issue 1, 2007, Pages 3-9

  Kanerva, Anna ^a,b   Raki, Mari ^a,b   Ranki, Tuuli ^a,b   Särkioja, Merja ^a,b   Koponen, Jarmo ^a,b   Desmond, Renee A ^c   Helin, Aija ^b   Stenman, Ulf Håkan ^b   Isoniemi, Helena ^b   Höckerstedt, Krister ^b   Ristimäki, Ari ^d   Hemminki, Akseli ^a,b  

^a UNIVERSITY OF HELSINKI   (Finland)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^c University of Alabama at Birmingham   (United States)

^d UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Adenovirus; Gene therapy; Reduced toxicity; Virus replication

Indexed keywords

ALANINE AMINOTRANSFERASE; APIGENIN; CHLORPROMAZINE; GEMCITABINE; ONCOLYTIC ADENOVIRUS; PHOSPHATE BUFFERED SALINE; PROTEIN P16; RETINOBLASTOMA PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG INDICATION; DRUG INHIBITION; DRUG SAFETY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE DEFICIENCY; IN VITRO STUDY; IN VIVO STUDY; LIVER PARENCHYMA; LIVER TOXICITY; MOUSE; NONHUMAN; ONCOLYTIC VIROTHERAPY; OVARY ADENOCARCINOMA; PRIORITY JOURNAL; TISSUE LEVEL; VIRUS INFECTION; VIRUS INHIBITION; VIRUS PARTICLE; WEIGHT REDUCTION;

ADENOCARCINOMA; ADENOVIRIDAE; ANIMALS; APIGENIN; CHLORPROMAZINE; FEMALE; HUMANS; LIVER; MICE; MICE, NUDE; ONCOLYTIC VIROTHERAPY; ONCOLYTIC VIRUSES; OVARIAN NEOPLASMS; TOXICITY TESTS; TUMOR CELLS, CULTURED; VIRUS REPLICATION;

ADENOVIRIDAE;

EID: 33846840763     PISSN: 1099498X     EISSN: 15212254     Source Type: Journal    
DOI: 10.1002/jgm.984     Document Type: Article

References (16)

1. Immonen A, Vapalahti M, Tyynela K, et al. AdvHSV-tk gene therapy with intravenous ganciclovir improves survival in human malignant glioma: a randomised, controlled study. Mol Ther 2004; 10: 967-972.
2. Xia ZJ, Chang JH, Zhang L, et al. Phase III randomized clinical trial of intraturnoral injection of ElB gene-deleted adenovirus (H101) combined with cisplatin-based chemotherapy in treating squamous cell cancer of head and neck or esophagus. Ai Zheng 2004; 23: 1666-1670.
3. Pearson S, Jia H, Kandachi K. China approves first gene therapy. Nat Biotechnol 2004; 22: 3-4.
4. Khuri FR, Nemunaitis J, Ganly I, et al. A controlled trial of intraturnoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer. Nat Med 2000; 6: 879-885.
5. Kirn D, Martuza RL, Zwiebel J. Replication-selective virotherapy for cancer: biological principles, risk management and future directions. Nat Med 2001; 7: 781-787.
6. Raki M, Kanerva A, Ristimaki A, et al. Combination of gemcitabine and Ad5/3-Delta24, a tropism modified conditionally replicating adenovirus, for the treatment of ovarian cancer. Gene Ther 2005; 12: 1198-1205.
7. Kojaoghlanian T, Flomenberg P, Horwitz MS. The impact of adenovirus infection on the immunocompromised host. Rev Med Virol 2003; 13: 155-171.
8. Raper SE, Chirmule N, Lee FS, et al. Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer. Mol Genet Metab 2003; 80: 148-158.
9. Dimitrov DS. Virus entry: molecular mechanisms and biomedical applications. Nat Rev Microbiol 2004; 2: 109-122.
10. Wang LH, Rothberg KG, Anderson RG. Mis-assembly of clathrin lattices on endosomes reveals a regulatory switch for coated pit formation. J Cell Biol 1993; 123: 1107-1117.
11. Sato F, Matsukawa Y, Matsumoto K, et al. Apigenin induces morphological differentiation and G2-M arrest in rat neuronal cells. Biochem Biophys Res Commun 1994; 204: 578-584.
12. Kanerva A, Zinn KR, Chaudhuri TR, et al. Enhanced therapeutic efficacy for ovarian cancer with a serotype 3 receptor-targeted oncolytic adenovirus. Mol Ther 2003; 8: 449-458.
13. Carette JE, Graat HC, Schagen FH, et al. Replication-dependent transgene expression from a conditionally replicating adenovirus via alternative splicing to a heterologous splice-acceptor site. J Gene Med 2005; 7: 1053-1062.
14. Blair GE, Dixon SC, Griffiths SA, et al. Restricted replication of human adenovirus type 5 in mouse cell lines. Virus Res 1989; 14: 339-346.
15. Lehman AF, Kreyenbuhl J, Buchanan RW, et al. The Schizophrenia Patient Outcomes Research Team (PORT): updated treatment recommendations 2003. Schizophr Bull 2004; 30: 193-217.
16. Nielsen SE, Young JF, Daneshvar B, et al. Effect of parsley (Petroselinum crispurn) intake on urinary apigenin excretion, blood antioxidant enzymes and biomarkers for oxidative stress in human subjects. Br J Nutr 1999; 81: 447-455.