Seven pregnancies and deliveries from non-mosaic Klinefelter syndrome patients using fresh and frozen testicular sperm

Journal of Assisted Reproduction and Genetics

Volumn 24, Issue 1, 2007, Pages 47-51

  Kyono, Koichi ^a,b   Uto, Hirofumi ^a,b   Nakajo, Yukiko ^a,b   Kumagai, Shima ^a,b   Araki, Yasuhisa ^c   Kanto, Satoru ^d  

^a Lady's Clinic Kyono   (Japan)

^b Kyono Reproduction Research Center Furukawa   (Japan)

^c The Institute for Advanced Reproductive Medical Technology   (Japan)

^d Tohokukoseinenkin Hospital   (Japan)

Author keywords

Cryopreserved thawed testicular sperm; ICSI; Non mosaic Klinefelter syndrome; TESE; TESE timing; Testicular sperm extraction

Indexed keywords

BUSERELIN ACETATE; CETRORELIX; CHORIONIC GONADOTROPIN; GONADORELIN AGONIST; GONADORELIN ANTAGONIST; HUMAN MENOPAUSAL GONADOTROPIN; RECOMBINANT FOLLITROPIN;

ADULT; AGRICULTURE; ARTICLE; CLINICAL ARTICLE; CRYOPRESERVATION; DELIVERY; EMBRYO; FEMALE; HUMAN; HUMAN CELL; INTRACYTOPLASMIC SPERM INJECTION; KLINEFELTER SYNDROME; LOW DRUG DOSE; MALE; OOCYTE; PREGNANCY; PRIORITY JOURNAL; SPERMATOZOON; SPERMATOZOON MOTILITY; TESTICULAR SPERM EXTRACTION; TESTIS BIOPSY;

ADULT; CRYOPRESERVATION; FEMALE; HUMANS; KLINEFELTER SYNDROME; LIVE BIRTH; MALE; PREGNANCY; PREGNANCY RATE; SEMEN PRESERVATION; SPERM INJECTIONS, INTRACYTOPLASMIC; TESTIS;

EID: 33846838882     PISSN: 10580468     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10815-006-9079-4     Document Type: Article

References (30)

1. Okada H, Fujioka H, Tatsumi N, Kanzaki M, Okuda Y, Fujisawa M, Hazama M, Matsumoto O, Gohji K, Arakawa S, Kamidono S. Klinefelter syndrome in the male infertility clinic. Hum Reprod 1999;14:946-52.
2. Poulakis V, Witzsch U, Diehl W, de Vries R, Becht E, Trotnow S. Birth of two infants with normal karyotype after intracytoplasmic injection of sperm obtained by testicular extraction from two men with non-mosaic Klinefelter's syndrome. Fertil Steril 2001;76:1060-2.
3. Kyono K, Fukunaga N, Haigo K, Chiba S, Araki Y. Pregnancy achieved following ICSI from a man with Klinefelter's syndrome and spinal cord injury. Hum Reprod 2001;16:2347-9.
4. Ron-EI R, Strassburger D, Gelman-Kohan S, Friedler S, Raziel A, Appleman Z. A 47, XXY fetus conceived after ICSI of spermatozoa from a patient with non-mosaic Klinefelter's syndrome. Hum Reprod 2000a;15:1804-6.
5. Palermo GP, Schlegel PN, Sills ES, Veeck L, Zaninovic N, Menendez S, Rosenwaks Z. Births after intracytoplasmic injection of sperm obtained by testicular extraction from men with non-mosaic Klinefelter's syndrome. N Engl J Med 1998;338:588-9.
6. Nodar F, De Vincentiis S, Olmed SB, Papier S, Urrutia F, Acosta AA. Birth of twin males with normal karyotype after intracytoplasmic sperm injection with use of testicular spermatozoa from a non-mosaic patient with Klinefelter's syndrome. Fertil Steril 1999;71:1149-52.
7. Levron J, Aviram-Goldring A, Madger L, Raviv, G, Barkai G, Dor J. Sperm chromosome analysis and outcome of IVF in patients with non-mosaic Klinefelter's syndrome. Fertil Steril 2000;74:925-9.
8. Friedler S, Raziel A, Strassburger D, SchachterM, Bern O, Ron-EI R. Outcome of ICSI using fresh and cryopreserved-thawed testicular spermatozoa in patients with non-mosaic Klinefelter's syndrome. Hum Reprod 2001;16:2616-20.
9. Ron-EI R, Razziel A, Strassburger D, Schachter M, Bern O, Friedler S. Birth of healthy male twins after intracytoplasmic sperm injection of frozen-thawed testicular spermatozoa from a patient with non-mosaic Klinefelter's syndrome. Fertil Steril 2000b;74:832-3.
10. Okada H, Goda K, Muto S, Maruyama O, Koshida M, Horie S. Four pregnancies in non-mosaic Klinefelter's syndrome using cryopreserved-thawed testicular spermatozoa. Fertil Steril 2005;84:13-6.
11. Rosenlund B, Hreinsson JG, Hovatta O. Birth of a healthy male after frozen thawed blastocyst transfer following intracytoplasmic injection of frozen thawed testicular spermatozoa from a man with nonmosaic Klinefelter's syndrome. J Assist Reprod Genet 2002;19:149-51.
12. Veeck LL. Preembryo grading. Atlas of the Human Oocyte and Early Conceptus. Vol. II. Baltimore: Williams & Wilkins; 1991. pp. 121-49.
13. Gardner DK, Schoolcraft WB. In vitro culture of human blastocysts. In: Jansen R, Mortimer D, editors. Towards reproductive certainty: Fertility & genetics beyond. Sydney: Parthenon Publishing; 1999. pp. 378-88.
14. Kyono K, Nakajo Y, Kumagai S, Sasaki S. Efficacy of low dose human chorionic gonadotropin (hCG) in a GnRH antagonist protocol. J Assist Reprod Genet 2006;23:223-8.
15. Fukunaga N, Haigo K, Kyono K, Araki Y. Efficiency of using frozen-thawed testicular sperm for multiple intracytoplasmic sperm injections. J Assist Reprod Genet 2001;18:634-7.
16. Cohen J, Garris GJ, Congedo-Ferrara TA, Kieck KA, Schimmel TW, Scott RR. Cryopreservation of single human spermatozoa. Hum Reprod 1997;12:994-1001.
17. Schuster TG, Keller LM, Dunn RL, Ohl DA, Smith GD. Ultrarapid freezing of very low numbers of sperm using cryoloops. Hum Reprod 2003;18:788-95.
18. Kyono K. unpublished data
19. Madgar I, Dor J, Weissenberg R, Radiv G, Menashe Y, Levron J. Prognostic value of a clinical and laboratory evaluationin patients with nonmosaic Klinefelter syndrome who are receiving assisted reproductive therapy. Fertil Steril 2002;77:1167-9.
20. Westlander G, Ekerhovd E, Granberg S, Hanson L, Hanson C, Berrgh C. Testicular ultrasonography and extended chromosome analysis in men with nonmosaic Klinefelter syndrome: a prospective study of possible predictive factors for successful sperm recovery. Fertil Steril 2001;75:1102-5.
21. Schlegel PN. Testicular sperm extraction: microdissection improves sperm yield with minimal tissue excision. Hum Reprod 1999;14:131-5.
22. Schiff JD, Palermo GD, Veeck LL, Goldstein M, Rosenwaks Z, Schlegel PN. Success of testicular sperm injection and intracytoplasmic sperm injection in men with Klinefelter syndrome. J Clin Endocrinol Meatb 2005;90:6264-7.
23. Raman JD, Schlegel PN. Aromatase inhibitors for male infertility. J Urol 2002;167:624-9.
24. Okada H, Maruyama O, Muto S, Yamamoto Y, Koshida M, Horie S. Age as a limiting factor for successful sperm retrieval in nonmosaic Klinefelter syndrome. Fertil Steril 2005;84(Suppl.):S206.
25. Tournaye H, Verheyen G, Nagy P, Goossens A, Ubaldi F, Silber S, Van Steirteghem A, Devroey P. Are there any predictive factors for successful testicular sperm recovery in azoospermic patients? Hum Reprod 1997;12:80-6.
26. Vernaeve V, Staessen C, Verheyen G, Van Steirteghem A, Devroey P, Tournaye H. Can biological or clinical parameters predict testicular sperm recovery in 47, XXY Klinefelter's syndrome patients? Hum Reprod 2004;19:1135-9.
27. Kyono K, Fuchinoue K, Yagi A, Nakajo Y, Yamashita A, Kumagai S. Successful pregnancy and delivery after transfer of a single blastocyst derived from a vitrified mature human oocyte. Fertil Steril 2005;84(1017e):5-6.
28. Lanfranco F, Kamischke A, Zitzmann M, Nieschlag E. Klinefelter's syndrome. Lancet 2004;364:273-83.
29. Denschlag D, Tempfer C, Kunze M, Wolff G, Keck C. Assisted reproductive techniques in patients with Klinefelter syndrome: a critical review. Fertil Steril 2004;82:775-9.
30. Staessen C, Tournaye H, Van Assche E, Michiels A, Van Landuyt L, Devroey P, Liebaers I, Van Steirteghem A. PGD in 47, XXY Klinefelter's syndrome patients. Hum Reprod Update 2003;9:319-30.