Verapamil Versus Saline in Electromotive Drug Administration for Peyronie's Disease: A Double-Blind, Placebo Controlled Trial

Journal of Urology

Volumn 177, Issue 3, 2007, Pages 972-975

  Greenfield, Jason M ^a   Shah, Sneha J ^a   Levine, Laurence A ^a  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

iontophoresis; penile induration; penis; questionnaires; verapamil

Indexed keywords

PAPAVERINE; PLACEBO; SODIUM CHLORIDE; VERAPAMIL;

ADULT; APPLICATION SITE ERYTHEMA; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE DURATION; DISEASE EXACERBATION; DOUBLE BLIND PROCEDURE; DRUG DELIVERY SYSTEM; DRUG EFFICACY; ECHOGRAPHY; ELECTROMOTIVE DRUG ADMINISTRATION; ERECTILE DYSFUNCTION; HUMAN; IONTOPHORESIS; MALE; MEASUREMENT; ORGAN SIZE; PATIENT SATISFACTION; PENIS; PEYRONIE DISEASE; PHYSICAL EXAMINATION; PRIORITY JOURNAL; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; STATISTICAL SIGNIFICANCE; THERAPY EFFECT; TREATMENT DURATION; TREATMENT OUTCOME;

DOUBLE-BLIND METHOD; HUMANS; IONTOPHORESIS; MALE; MIDDLE AGED; PATIENT SATISFACTION; PENILE ERECTION; PENILE INDURATION; RECOVERY OF FUNCTION; TREATMENT OUTCOME; VASODILATOR AGENTS; VERAPAMIL;

EID: 33846834195     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.juro.2006.10.065     Document Type: Article

References (16)

1. 2+ channel blockers modulate metabolism of collagens within the extracellular matrix. Proc Natl Acad Sci U S A 93 (1996) 5478
2. Bronaugh R.L., and Maibach H.I.E. Percutaneous Absorption: Mechanisms-Methodology-Drug Delivery (1989), Marcel Dekker, New York
3. Higuchi W.I., Li S.K., Ghanem A.H., Zhu H., and Song Y. Mechanistic aspects of iontophoresis in human epidermal membrane. J Control Release 62 (1999) 13
4. Levine L.A., Estrada C.R., Shou W., and Cole A. Tunica albuginea tissue analysis after electromotive drug administration. J Urol 169 (2003) 1775
5. DiStasi S.M., Giannantoni A., Capelli G., Jannini E.A., Virgili G., Storti L., et al. Transdermal electromotive administration of verapamil and dexamethasone for Peyronie's disease. BJU Int 91 (2003) 825
6. DiStasi S.M., Giannantoni A., Stephen R.L., Capelli G., Giurioli A., Jannini E.A., et al. A prospective, randomized study using transdermal electromotive administration of verapamil and dexamethasone for Peyronie's disease. J Urol 171 (2004) 1605
7. Althof S.E., Corty E.W., Levine S.B., Levine F., Burnett A.L., McVary K., et al. EDITS: development of questionnaires for evaluating satisfaction with treatments for erectile dysfunction. Urology 53 (1999) 793
8. Levine L.A., Goldman K.E., and Greenfield J.M. Experience with intraplaque injection of verapamil for Peyronie's disease. J Urol 168 (2002) 621
9. Martin D.J., Badwan K., Parker M., and Mulhall J.P. Transdermal application of verapamil gel to the penile shaft fails to infiltrate the tunica albuginea. J Urol 168 (2002) 2483
10. Riedl C.R., Plas E., Engelhardt P., Daha K., and Pfluger H. Iontophoresis for treatment of Peyronie's disease. J Urol 163 (2000) 95
11. Montorsi F., Salonia A., Guazzoni G., Barbieri L., Colombo R., Brausi M., et al. Transdermal electromotive multi-drug administration for Peyronie's disease: preliminary results. J Androl 21 (2000) 85
12. Stephens, R: Personal communication. Mirandola, Italy: Physion Co.
13. Kadioglu A., Tefekli A., Erol H., Oktar T., Tunc M., and Tellaloglu S. A retrospective review of 307 men with Peyronie's disease. J Urol 168 (2002) 1075
14. Mulhall J.P., Parker M., and Guhring P. The natural history of Peyronie's disease (2004) Presented at biennial meeting of International Society of Sexual Medicine, Buenos Aires, Argentina, October 17-21
15. Ojingwa J.C., and Isserhoff R.R. Electrical stimulation of wound healing. J Invest Dermatol 121 (2003) 1
16. Levine L.A., and Greenfield J.M. Establishing a standardized evaluation of the man with Peyronie's disease. Int J Impot Res 15 (2003) S103