Putative mechanism of the itch-scratch circle: Repeated scratching decreases the cutaneous level of prostaglandin D2, a mediator that inhibits itching

Prostaglandins Leukotrienes and Essential Fatty Acids

Volumn 76, Issue 2, 2007, Pages 93-101

  Sugimoto, Masanori ^a   Arai, Iwao ^a   Futaki, Nobuko ^a   Honma, Yusuke ^a   Sakurai, Takanobu ^a   Hashimoto, Yuki ^a   Nakaike, Shiro ^a  

^a TAISHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

6 OXOPROSTAGLANDIN F1 ALPHA; CYCLOOXYGENASE 1; PROSTAGLANDIN D2; PROSTAGLANDIN E2; PROSTAGLANDIN F2 ALPHA; PROSTAGLANDIN SYNTHASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EXPERIMENTAL MODEL; IMMUNOHISTOCHEMISTRY; MALE; MEDIATOR RELEASE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; PRURITUS; SCRATCHING; SKIN; SKIN INJURY; TISSUE LEVEL; WESTERN BLOTTING;

ANIMALS; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DERMATITIS, ATOPIC; INTRAMOLECULAR OXIDOREDUCTASES; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; PROSTAGLANDIN D2; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROSTAGLANDINS; PRURITUS; SKIN;

MUS;

EID: 33846829491     PISSN: 09523278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.plefa.2006.11.007     Document Type: Article

References (37)

1. Wahlgren C.F. Itch and atopic dermatitis: an overview. J. Dermatol. 26 (1999) 770-779
2. Kimura T., and Miyazawa H. The 'butterfly' sign in patients with atopic dermatitis: evidence for the role of scratching in the development of skin manifestations. J. Am. Acad. Dermatol. 21 (1989) 579-580
3. Matsuda H., Watanabe N., Geba G.P., et al. Development of atopic dermatitis-like skin lesion with IgE hyperproduction in NC/Nga mice. Int. Immunol. 9 (1997) 461-466
4. Watanabe N., Tomimori Y., Saito K., et al. Chymase inhibitor improves dermatitis in NC/Nga mice. Int. Arch. Allergy Immunol. 128 (2002) 229-234
5. Hashimoto Y., Arai I., Nakanishi Y., Sakurai T., Nakamura A., and Nakaike S. Scratching of their skin by NC/Nga mice leads to development of dermatitis. Life Sci. 76 (2004) 783-794
6. Takahashi N., Arai I., Honma Y., et al. Scratching behavior and dermatitis: scratching behavior and spontaneous- or allergic contact-induced dermatitis in NC/Nga mice. Exp. Dermatol. 14 (2005) 830-837
7. Takano N., Arai I., and Kurachi M. Analysis of the spontaneous scratching behavior by NC/Nga mice: a possible approach to evaluate antipruritics for subjects with atopic dermatitis. Eur. J. Pharmacol. 471 (2003) 223-228
8. 2 biosynthesis in NC/Nga mice with atopic dermatitis. Exp. Dermatol. 14 (2005) 898-905
9. Goodwin J.S. Immunomodulation by eicosanoids and anti-inflammatory drugs. Curr. Opin. Immunol. 2 (1989) 264-268
10. Larsen G.L., and Henson P.M. Mediators of inflammation. Annu. Rev. Immunol. 1 (1983) 335-359
11. Marnett L.J., Rowlinson S.W., Goodwin D.C., Kalgutkar A.S., and Lanzo C.A. Arachidonic acid oxygenation by COX-1 and COX-2. Mechanisms of catalysis and inhibition,. J. Biol. Chem. 274 (1999) 22903-22906
12. Needleman P., Turk J., Jakschik B.A., et al. Arachidonic acid metabolism. Annu. Rev. Biochem. 55 (1986) 69-102
13. Ruzicka T., Simmet T., Peskar B.A., and Ring J. Skin levels of arachidonic acid-derived inflammatory mediators and histamine in atopic dermatitis and psoriasis. J. Invest. Dermatol. 86 (1986) 105-108
14. 2 on platelet aggregation in different species. Prostaglandins 16 (1978) 373-388
15. 2 and its analogues. Br. J. Pharmacol. 85 (1985) 367-375
16. 2. Prostaglandins 35 (1988) 277-300
17. 2 inhibits inducible nitric oxide synthase expression in rat vascular smooth muscle cells. Circ. Res. 82 (1998) 204-209
18. 2. J. Lipid. Mediat. Cell Signal. 14 (1996) 71-82
19. 2 and sleep regulation. Biochim. Biophys. Acta 1436 (1999) 606-615
20. 2 in the hypothermia of rats caused by bacterial lipopolysaccharide. Proc. Natl. Acad. Sci. USA 79 (1982) 6093-6097
21. Arai I., Takano N., Hashimoto Y., et al. Prostanoid DP(1) receptor agonist inhibits the pruritic activity in NC/Nga mice with atopic dermatitis. Eur. J. Pharmacol. 505 (2004) 229-235
22. Sugimoto M., Arai I., Futaki N., et al. Time course changes of scratching counts, dermatitis symptoms, and levels of cutaneous prostaglandins in NC/Nga mice. Exp. Dermatol. 15 (2006) 875-882
23. 2 accelerate the recovery of cutaneous barrier disruption induced by mechanical scratching in mice. Eur. J. Pharmacol. 518 (2005) 56-62
24. Honma Y., Arai I., Sakurai T., et al. Effects of indomethacin and dexamethasone on mechanical scratching-induced cutaneous barrier disruption in mice. Exp. Dermatol. 15 (2006) 501-508
25. Laouini D., Elkhal A., Yalcindag A., Kawamoto S., Oettgen H., and Geha R.S. COX-2 inhibition enhances the TH2 immune response to epicutaneous sensitization. J. Allergy Clin. Immunol. 116 2 (2005) 390-396
26. Holtzman M.J., Zhang V., Hussain H., Roswit W.T., and Wilson J.D. Prostaglandin H synthase and lipoxygenase gene families in the epithelial cell barrier. Ann. NY Acad. Sci. 744 (1994) 58-77 Review
27. Kozuka T., Francis D.M., and Greaves M.W. Arachidonic acid metabolites and the skin. Ann. Acad. Med. Singapore 12 1 (1983) 87-91
28. Sugimoto M., Arai I., Futaki N., Hashimoto Y., Honma Y., and Nakaike S. Role of COX-1 and COX-2 on skin PGs biosynthesis by mechanical scratching in mice. Prostaglandins Leukot. Essent. Fatty Acids 75 (2006) 1-8
29. Ikoma A., Fartasch M., Heyer G., Miyachi Y., Handwerker H., and Schmelz M. Painful stimuli evoke itch in patients with chronic pruritus: central sensitization for itch. Neurology 62 (2004) 212-217
30. Urade Y., and Hayaishi O. Prostaglandin D synthase: structure and function. Vitam. Horm. 58 (2000) 89-120
31. Ujihara M., Horiguchi Y., Ikai K., and Urade Y. Characterization and distribution of prostaglandin D synthetase in rat skin. J. Invest. Dermatol. 90 (1988) 448-451
32. Kampfer H., Brautigam L., Geisslinger G., Pfeilschifter J., and Frank S. Cyclooxygenase-1-coupled prostaglandin biosynthesis constitutes an essential prerequisite for skin repair. J. Invest. Dermatol. 120 5 (2003) 880-890
33. Ruzicka T., Walter J.F., and Printz M.P. Changes in arachidonic acid metabolism in UV-irradiated hairless mouse skin. J. Invest. Dermatol. 81 (1983) 300-303
34. Fogh K., Herlin T., and Kragballe K. Eicosanoids in skin of patients with atopic dermatitis: prostaglandin E2 and leukotriene B4 are present in biologically active concentrations. J. Allergy Clin. Immunol. 83 (1989) 450-455
35. van der Schaar W.W., and Lamberts H. Scratching for the itch in eczema; a psychodermatologic approach. Ned. Tijdschr. Geneeskd. 141 (1997) 2049-2051
36. Klein P.A., and Clark R.A. An evidence-based review of the efficacy of antihistamines in relieving pruritus in atopic dermatitis. Arch. Dermatol. 135 (1999) 1522-1525
37. Munday J., Bloomfield R., Goldman M., et al. Chlorpheniramine is no more effective than placebo in relieving the symptoms of childhood atopic dermatitis with a nocturnal itching and scratching component. Dermatology 205 (2002) 40-45