D-501036, a novel selenophene-based triheterocycle derivative, exhibits potent in vitro and in vivo antitumoral activity which involves DNA damage and ataxia telangiectasia-mutated nuclear protein kinase activation

Molecular Cancer Therapeutics

Volumn 6, Issue 1, 2007, Pages 193-202

  Juang, Shin Hun ^a   Lung, Chia Chi ^b   Hsu, Pi Chen ^c   Hsu, Kuo Shun ^b   Li, Yu Chen ^c   Hong, Pao Chiung ^c   Shiah, Her Shyong ^b   Kuo, Ching Chuan ^b   Huang, Ching Wei ^c   Wang, Yu Chin ^c   Huang, Leeyuan ^c   Chen, Tom S ^c   Chen, Shyh Fong ^c   Fu, Kuo Chu ^c   Hsu, Cheng Li ^c   Lin, Meng Ju ^c   Chang, Ching Jer ^e   Ashendel, Curtis L ^e   Chan, Thomas C K ^e   Chou, Kai Ming ^f   Chang, Jang Chang ^b,d   more..

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^c DEVELOPMENT CENTER FOR BIOTECHNOLOGY   (Taiwan)

^d TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^e PURDUE UNIVERSITY   (United States)

^f UNIVERSITY OF SOUTH ALABAMA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,5 BIS(5 HYDROXYMETHYL 2 SELENIENYL) 3 HYDROXYMETHYL N METHYLPYRROLE; ANTINEOPLASTIC AGENT; ATM PROTEIN; CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; CYCLIN DEPENDENT KINASE INHIBITOR 1; D 501036; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); ETOPOSIDE; PACLITAXEL; PROTEIN P53; PROTEIN TYROSINE PHOSPHATASE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; VINCRISTINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BRONCHUS MUCOSA; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CANCER RESISTANCE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE S PHASE; CELL DEATH; CONTROLLED STUDY; CROSS RESISTANCE; DNA ADDUCT; DNA DAMAGE; DNA STRAND BREAKAGE; DOSE RESPONSE; DRUG DNA BINDING; DRUG DOSE COMPARISON; DRUG EXPOSURE; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FIBROBLAST; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; KIDNEY CARCINOMA; KIDNEY PROXIMAL TUBULE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULSED FIELD GEL ELECTROPHORESIS; TUMOR XENOGRAFT; UPREGULATION; WEIGHT REDUCTION;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CARCINOMA, RENAL CELL; CELL CYCLE PROTEINS; DNA ADDUCTS; DNA DAMAGE; DNA-BINDING PROTEINS; DRUG RESISTANCE, NEOPLASM; ENZYME ACTIVATION; FLOW CYTOMETRY; HELA CELLS; HETEROCYCLIC COMPOUNDS, 3-RING; HT29 CELLS; HUMANS; MALE; MICE; MICE, NUDE; ORGANOSELENIUM COMPOUNDS; PROTEIN KINASE C; PROTEIN KINASE C-ALPHA; PROTEIN-SERINE-THREONINE KINASES; PYRROLES; REACTIVE OXYGEN SPECIES; S PHASE; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEINS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 33846821661     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-06-0482     Document Type: Article

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