Relationship between daily dose of imatinib per square meter and its plasma concentration in patients with chronic-phase chronic myeloid leukemia (CML)

Leukemia Research

Volumn 31, Issue 4, 2007, Pages 574-575

  Horikoshi, Akira ^a   Takei, Kazuhiro ^a   Sawada, Shigemasa ^a  

^a NIHON UNIVERSITY   (Japan)

Author keywords

Body surface area; Chronik phase; CML; Imatinib mesylate; Plasma concentration; Quadratic relationship

Indexed keywords

BCR ABL PROTEIN; IMATINIB; MESSENGER RNA;

CHRONIC MYELOID LEUKEMIA; CLINICAL ARTICLE; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG DOSE REDUCTION; HUMAN; LETTER; PRIORITY JOURNAL; TREATMENT RESPONSE;

ANTINEOPLASTIC AGENTS; FUSION PROTEINS, BCR-ABL; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LEUKEMIA, MYELOID, CHRONIC-PHASE; PIPERAZINES; PROTEIN-TYROSINE KINASES; PYRIMIDINES;

EID: 33846818881     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.leukres.2006.05.019     Document Type: Letter

References (5)

1. Kantarjian H., Sawyers C., Hochhaus A., Guilhot F., Schiffer C., Gambacorti-Passerini C., et al. Hematologic and cytogenetic response to imatinib mesylate in chronic myelogenous leukemia. N Engl J Med 346 (2002) 645-652
2. O'Brien S.G., Guilhot F., Larson R.A., Gathmann I., Baccarani M., Cervantes F., et al. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med 348 (2003) 994-1004
3. Druker B.J., Talpaz M., Resta D.J., Peng B., Buchdunger E., Ford J.M., et al. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med 344 (2001) 1031-1037
4. Horikoshi A., Takei K., and Sawada S. Effects of lower dose of imatinib to CML patients. Leukemia Res 27 (2003) 1167
5. Bakhtiar R., Lohne J., Ramos L., Khemani L., Hayes M., and Tse F. High-throughput quantification of the anti-leukemia drug STI571 (Gleevec™) and its main metabolite (CGP 74588) in human plasma using liquid chromatography-tandem mass spectrometry. J Chromatogr B 768 (2002) 325-340