Continuous brachial plexus blockade in combination with the NMDA receptor antagonist memantine prevents phantom pain in acute traumatic upper limb amputees

European Journal of Pain

Volumn 11, Issue 3, 2007, Pages 299-308

  Schley, M ^a,b   Topfner, S ^b   Wiech, K ^b   Schaller, H E ^b   Konrad, C J ^a   Schmelz, M ^a   Birbaumer, N ^b,c  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c UNIVERSITY OF TRENTO   (Italy)

Author keywords

Acute traumatic amputation; Continuous brachial plexus block; Deafferentation hyperexcitability; Glutamate antagonism

Indexed keywords

MEMANTINE; MEPIVACAINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PLACEBO; ROPIVACAINE;

ADULT; ARM AMPUTATION; ARTICLE; BRACHIAL PLEXUS ANESTHESIA; CLINICAL ARTICLE; CLINICAL TRIAL; CONTINUOUS INFUSION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG DOSE INCREASE; DRUG EFFECT; FATIGUE; FEMALE; FOLLOW UP; HEADACHE; HUMAN; MALE; NAUSEA; OUTCOME ASSESSMENT; PAIN THRESHOLD; PHANTOM PAIN; POSTOPERATIVE CARE; PREVALENCE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RECEPTOR BLOCKING; TREATMENT OUTCOME;

ADULT; AMIDES; AMPUTATION, TRAUMATIC; ANESTHETICS, LOCAL; BRACHIAL PLEXUS; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; EXCITATORY AMINO ACID ANTAGONISTS; FEMALE; GLUTAMIC ACID; HUMANS; MALE; MEMANTINE; MIDDLE AGED; NERVE BLOCK; NOCICEPTORS; PAIN MEASUREMENT; PAIN THRESHOLD; PAIN, INTRACTABLE; PHANTOM LIMB; RECEPTORS, N-METHYL-D-ASPARTATE; TREATMENT OUTCOME;

EID: 33846817366     PISSN: 10903801     EISSN: 15322149     Source Type: Journal    
DOI: 10.1016/j.ejpain.2006.03.003     Document Type: Article

References (44)

1. Akahoshi M.P., Enriquenz N.C., Maki J.K., and Merrigan D.M. Safety and reliability of the Travenol Infusor - in administering chemotherapy in the home. J Pharmacy Technol Mar/Apr (1987) 65-68
2. Areosa Sastre A., McShane R., and Sherriff F. Memantine for dementia. Cochrane Database Syst Rev 18 4 (2004) CD003154
3. Bach S., Noreng M.F., and Tjéllden N.U. Phantom limb pain in amputees during the first 12 months following limb amputation, after preoperative lumbar epidural block. Pain 33 (1988) 297-301
4. Benrath J., Brechtel C., Stark J., and Sandkuhler J. Low dose of S + -ketamine prevents long-term potentiation in pain pathways under strong opioid analgesia in the rat spinal cord in vivo. Br J Anaesth 95 4 (2005) 518-523
5. Birbaumer N., Lutzenberger W., Montoya P., Larbig W., Unertl K., Töpfner S., et al. Effects of regional anesthesia on phantom limb pain are mirrored in changes in cortical reorganization. J Neurosci 17 14 (1997) 5503-5508
6. Burton A.W., Lee D.H., Saab C., and Chung J.M. Preemptive intrathecal ketamine injection produces a long-lasting decrease in neuropathic pain behaviors in a rat model. Reg Anesth Pain Med 24 (1999) 208-213
7. Carlen P.L., Wall P.D., Nadvorna H., and Steinbach T. Phantom limbs and related phenomena in recent traumatic amputations. Neurology 28 (1978) 211-217
8. Coderre T.J., Katz J., Vaccarino A.L., and Melzack R. Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence. Pain 52 (1993) 259-285
9. In: Cousins M.J., and Bridenbaugh P.O. (Eds). Neural Blockade in Clinical Anesthesia and Management of Pain (1988), Lippincott Williams and Wilkins, Baltimore 998-1101
10. Devor M., and Seltzer Z. Pathophysiology of damaged nerves in reaction of chronic pain. In: Wall P.D., and Melzack R. (Eds). Textbook of pain (1999), Churchill Livingstone Edinburgh, London 651-665
11. Dimpfel W. Effects of memantine on synaptic transmission in the hippocampus in vitro. Arzneimittelforschung 45 1 (1995) 1-5
12. Eisenberg E., LaCross S., and Strassman A.M. The effects of the clinically tested NMDA receptor antagonist memantine on carrageenan-induced thermal hyperalgesia in rats. J Pharmacol 255 (1994) 123-129
13. Enneking F., Scarborough M.T., and Radson E.A. Local anesthetic infusion through nerve sheath catheters for analgesia following upper limb extremity amputation. Regional Anesth 22 4 (1997) 351-356
14. 2+ in hippocampal slices. Neuropharmacology 38 9 (1999) 1253-1259
15. Hayes C., Armstrong-Brown A., and Burstal R. Perioperative intravenous ketamine infusion for the prevention of persistent post-amputation pain: a randomized, controlled trial. Anaesth Intensive Care 32 3 (2004) 330-338
16. Hickey R., Candido K.D., Ramamurthy S., Winnie A.P., Blanchard J., Raza S.M., et al. Brachial plexus block with a new local anesthetic. Can J Anesth 37 (1990) 732-738
17. Jahangiri M., Bradley J.W.P., Jayatunga A.P., and Dark C.H. Prevention of phantom limb pain after major lower limb amputation by epidural infusion of diamorphine, clonidine and bupivacain. Ann R Coll Surg Engl 76 (1994) 324-326
18. Jensen T.S., and Rasmussen P. Phantom pain and other phenomena after amputation. In: Wall P.D., and Melzack R. (Eds). Textbook of pain (1999), Churchill Livingstone Edinburgh, London 651-665
19. Jensen T.S., Krebs B., Nielsen J., and Rasmussen P. Phantom limb, phantom pain and stump pain in amputees during the first 6 months following limb amputation. Pain 17 (1983) 243-256
20. Jensen T.S., Krebs B., Nielsen J., and Rasmussen P. Immediate and long-term phantom limb pain in amputees: incidence, clinical characteristics and relationship to pre-amputation limb pain. Pain 21 (1985) 267-278
21. Knox D.J., McLeod B.J., and Goucke C.R. Acute phantom limb pain controlled by ketamine. Anaesth Intensive Care 23 5 (1995) 620-622
22. Kooijman C.M., Dijkstra P.U., Geertzen J.H.B., Elzinga A., and Schans C.P.v.d. Phantom pain and phantom sensations in upper limb amputees: an epidemiological study. Pain 87 (2000) 33-41
23. Kornhuber J., and Quack G. Cerebrospinal fluid and serum concentrations of the N-methyl-d-aspartate-(NMDA) receptor antagonist memantine in man. Neurosci Lett 195 (1995) 137-139
24. Lei L.G., Sun S., Gao Y.J., Zhao Z.Q., and Zhang Y.Q. NMDA receptors in the anterior cingulate cortex mediate pain-related aversion. Exp Neurol 189 2 (2004) 413-421
25. Lierz P., Schroegendorfen K., Choi S., Felleiter P., and Kress H.G. Continuous block of both brachial plexus with ropivacaine in phantom limb pain: a case report. Pain 78 (1998) 135-137
26. Maier C., Dertwinkel R., Mansourian N., Hosbach I., Schwenkreis P., Senne I., et al. Efficacy of the NMDA-receptor antagonist memantine in patients with chronic phantom limb pain - results of a randomized double-blinded, placebo-controlled trial. Pain 103 3 (2003) 277-283
27. Mezzatesta J.P., Scott D.A., Schweitzer S.A., and Selander D.E. Continuous axillary brachial plexus block for postoperative pain relief. Regional Anesth 22 4 (1997) 357-362
28. Nikolajsen L., Hansen C.L., Nielsen J., Keller J., Arendt-Nielsen L., and Jensen T.S. The effect of ketamine on phantom pain: a central neuropathic disorder maintained by peripheral input. Pain 67 (1996) 69-77
29. Nikolajsen L., Hansen P.O., and Jensen T.S. Oral ketamine therapy in the treatment of postamputation stump pain. Acta Anaesthesiol Scand 41 (1997) 427-429
30. Nikolajsen L., Ilkjaer S., Christensen J.H., Kroner K., and Jensen T.S. Randomised trial of epidural bupivacaine and morphine prevention of stump and phantom pain in lower-limb amputation. Lancet 35 (1997) 1353-1357
31. Nikolajsen L., Gottrup H., Kristensen A.G.D., and Jensen T.S. Memantine (a N-methyl-d-aspartate receptor antagonist) in the treatment of neuropathic pain after amputation or surgery: a randomized double-blinded cross-over study. Anesth Analg 91 (2000) 960-966
32. Parsons C.G., Danysz W., and Quack G. Memantine is a clinically well tolerated N-methyl-d-aspartate (NMDA) receptor antagonist - a review of preclinical data. Neuropharmacology 38 (1999) 735-767
33. Pinzur M.S., Garla G.P., Pluth T., and Vrbos L. Continuous postoperative infusion of a regional anesthetic after an amputation of the lower extremity. A randomized clinical trial. J Bone Joint Surg 78 (1996) 1501-1505
34. Rosenblatt R., Pepitone-Rockwell F., and McKillop M.J. Continuous axillary analgesia for traumatic hand injury. Anesthesiology 51 (1979) 565-566
35. Sang C. NMDA-receptor antagonists in neuropathic pain: Experimental methods to clinical trials. J Pain Sympt Manage 19 (2000) 21-25
36. Schwenkreis P., Maier C., Pleger B., Mansourian N., Dertwinkel R., Malin J.P., et al. NMDA-mediated mechanisms in cortical excitability changes after limb amputation. Acta Neurol Scand 108 3 (2003) 179-184
37. Sherman R.A., Sherman C.J., and Gall N.G. A survey of current phantom limb pain treatment in the United States. Pain 8 1 (1980) 85-99
38. Sherman R.A., Sherman C.J., and Parker L. Chronic phantom and stump pain among American veterans. Pain 18 (1984) 83-95
39. Stubhaug A., and Breivik H. Long-term treatment of chronic neuropathic pain with the NMDA (N-methyl-d-aspartate) receptor antagonist ketamine. Acta Anaesthesiol Scand 41 3 (1997) 329-331
40. In: Wall P.D., and Melzack R. (Eds). Textbook of Pain (1990), Churchill Livingstone, New York 1023-1025
41. Warncke T., Stubhaug A., and Jorum E. Preinjury treatment with morphine or ketamine inhibits the development of experimentally induced secondary hyperalgesia in man. Pain 86 (2000) 293-303
42. Weiss T., Miltner W.H., Huonker R., Friedel R., Schmidt I., and Taub E. Rapid functional plasticity of the somatosensory cortex after finger amputation. Exp Brain Res 134 2 (2000) 199-203
43. Wiech K., Kiefer R.T., Töpfner S., Preissl H., Braun C., Unertl K., et al. A placebo-controlled randomized crossover trial of the N-methyl-d-aspartic acid receptor antagonist, memantine, in patients with chronic phantom limb pain. Anesth Analg 98 (2004) 408-413
44. Wu M.F., Pang Z.P., Zhuo M., and Xu Z.C. Prolonged membrane potential depolarization in cingulate pyramidal cells after digit amputation in adult rats. Mol Pain 19 (2005) 1-23