The PlA1/A2 polymorphism of glycoprotein IIIa and cerebrovascular events in hypertension: Increased risk of ischemic stroke in high-risk patients

Journal of Hypertension

Volumn 25, Issue 3, 2007, Pages 551-556

  Lanni, Francesca ^a   Santulli, Gaetano ^a   Izzo, Raffaele ^a   Rubattu, Speranza ^b,c   Zanda, Bastianina ^d   Volpe, Massimo ^b,c   Iaccarino, Guido ^a   Trimarco, Bruno ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b IRCCS NEUROMED   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d UNIVERSITY OF SASSARI   (Italy)

Author keywords

Blood flow; Coagulation; Genetics; Hypertension; Platelets; Polymorphism; Stroke

Indexed keywords

GLYCOPROTEIN IIIA; BETA3 INTEGRIN;

ADULT; ARTICLE; CEREBROVASCULAR ACCIDENT; CONFIDENCE INTERVAL; CONTROLLED STUDY; FEMALE; GENETIC POLYMORPHISM; GENOTYPE; HIGH RISK PATIENT; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; MULTIPLE REGRESSION; PRIORITY JOURNAL; RISK FACTOR; AGED; BLOOD; BLOOD PRESSURE; BRAIN ISCHEMIA; GENETICS; ITALY; MIDDLE AGED; PHYSIOLOGY; RETROSPECTIVE STUDY; RISK; SINGLE NUCLEOTIDE POLYMORPHISM;

AGED; BLOOD PRESSURE; BRAIN ISCHEMIA; CEREBROVASCULAR ACCIDENT; FEMALE; HUMANS; HYPERTENSION; INTEGRIN BETA3; ITALY; MALE; MIDDLE AGED; ODDS RATIO; POLYMORPHISM, SINGLE NUCLEOTIDE; RETROSPECTIVE STUDIES; RISK FACTORS;

EID: 33846813609     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/HJH.0b013e328013cd67     Document Type: Article

References (36)

1. Hachinski V. Stroke: the next 30 years. Stroke 2002; 33:1-4.
2. Group PC. Randomised trial of a perindopril-based blood-pressure-lowering regimen among 6,105 individuals with previous stroke or transient ischaemic attack. Lancet 2001; 358:1033-1041.
3. MacMahon S, Rodgers A, Neal B, Chalmers J. Blood pressure lowering for the secondary prevention of myocardial infarction and stroke. Hypertension 1997; 29:537-538.
4. Rosand J, Altshuler D. Human genome sequence variation and the search for genes influencing stroke. Stroke 2003; 34:2512-2516.
5. Humphries SE, Morgan L. Genetic risk factors for stroke and carotid atherosclerosis: insights into pathophysiology from candidate gene approaches. Lancet Neurol 2004; 3:227-235.
6. Phillips DR, Charo IF, Parise LV, Fitzgerald LA. The platelet membrane glycoprotein IIb-IIIa complex. Blood 1988; 71:831-843.
7. del Zoppo GJ. The role of platelets in ischemic stroke. Neurology 1998; 51:S9-S14.
8. Schomig A, Schmitt C, Dibra A, Mehilli J, Volmer C, Schuhlen H, et al. One year outcomes with abciximab vs. placebo during percutaneous coronary intervention after pre-treatment with clopidogrel. Eur Heart J 2005; 26:1379-1384.
9. Carter AM, Catto AJ, Bamford JM, Grant PJ. Platelet GP IIIa PlA and GP Ib variable number tandem repeat polymorphisms and markers of platelet activation in acute stroke. Arterioscler Thromb Vasc Biol 1998; 18:1124-1131.
10. Vijayan KV, Goldschmidt-Clermont PJ, Roos C, Bray PF. The Pl(A2) polymorphism of integrin beta(3) enhances outside-in signaling and adhesive functions. J Clin Invest 2000; 105:793-802.
11. Goodall AH, Curzen N, Panesar M, Hurd C, Knight CJ, Ouwehand WH, et al. Increased binding of fibrinogen to glycoprotein IIIa-proline33 (HPA-1b, PlA2, Zwb) positive platelets in patients with cardiovascular disease. Eur Heart J 1999; 20:742-747.
12. Undas A, Brummel K, Musial J, Mann KG, Szczeklik A. Pl(A2) polymorphism of beta(3) integrins is associated with enhanced thrombin generation and impaired antithrombotic action of aspirin at the site of microvascular injury. Circulation 2001; 104:2666-2672.
13. Cooke GE, Liu-Stratton Y, Ferketich AK, Moeschberger ML, Frid DJ, Magorien RD, et al. Effect of platelet antigen polymorphism on platelet inhibition by aspirin, clopidogrel, or their combination. J Am Coll Cardiol 2006; 47:541-546.
14. Weiss EJ, Bray PF, Tayback M, Schulman SP, Kickler TS, Becker LC, et al. A polymorphism of a platelet glycoprotein receptor as an inherited risk factor for coronary thrombosis. N Engl J Med 1996; 334:1090-1094.
15. Anderson JL, King GJ, Bair TL, Elmer SP, Muhlestein JB, Habashi J, et al. Associations between a polymorphism in the gene encoding glycoprotein IIIa and myocardial infarction or coronary artery disease. J Am Coll Cardiol 1999; 33:727-733.
16. Slowik A, Dziedzic T, Turaj W, Pera J, Glodzik-Sobanska L, Szermer P, et al. A2 allele of GpIIIa gene is a risk factor for stroke caused by large-vessel disease in males. Stroke 2004; 35:1589-1593.
17. Kekomaki S, Hamalainen L, Kauppinen-Makelin R, Palomaki H, Kaste M, Kontula K. Genetic polymorphism of platelet glycoprotein IIIa in patients with acute myocardial infarction and acute ischaemic stroke. J Cardiovasc Risk 1999; 6:13-17.
18. Ridker PM, Hennekens CH, Schmitz C, Stampfer MJ, Lindpaintner K. PIA1/A2 polymorphism of platelet glycoprotein IIIa and risks of myocardial infarction, stroke, and venous thrombosis. Lancet 1997; 349:385-388.
19. Stella P, Bigatti G, Tizzoni L, Barlassina C, Lanzani C, Bianchi G, et al. Association between aldosterone synthase (CYP11B2) polymorphism and left ventricular mass in human essential hypertension. J Am Coll Cardiol 2004; 43:265-270.
20. Guidelines Committee. 2003 European Society of Hypertension - European Society of Cardiology guidelines for the management of arterial hypertension. J Hypertens 2003; 21:1011-1053.
21. De Luca N, Izzo R, IaccarinoG, Malini PL, Morisco C, Rozza F, et al. The use of a telematic connection for the follow-up of hypertensive patients improves the cardiovascular prognosis. J Hypertens 2005; 23:1417-1423.
22. National Cholesterol Education Program Coordinating Committee. Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation 2002; 106:3143-3421.
23. Diagnosis and classification of diabetes mellitus. Diabetes Care 2005; 28 (Suppl 1):S37-S42.
24. Adams H, Adams R, Del Zoppo G, Goldstein LB. Guidelines for the early management of patients with ischemic stroke: 2005 guidelines update a scientific statement from the Stroke Council of the American Heart Association/American Stroke Association. Stroke 2005; 36:916-923.
25. Adams HP Jr, Bendixen BH, Kappelle LJ, Biller J, Love BB, Gordon DL, et al. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke 1993; 24:35-41.
26. Dichgans M, Markus HS. Genetic association studies in stroke: methodological issues and proposed standard criteria. Stroke 2005; 36:2027-2031.
27. Rubattu S, Di Angelantonio E, Nitsch D, Gigante B, Zanda B, Stanzione R, et al. Polymorphisms in prothrombotic genes and their impact on ischemic stroke in a Sardinian population. Thromb Haemost 2005; 93:1095-1100.
28. Iaccarino G, Lanni F, Cipolletta E, Trimarco V, Izzo R, Iovino GL, et al. The Glu27 allele of the beta2 adrenergic receptor increases the risk of cardiac hypertrophy in hypertension. J Hypertens 2004; 22:2117-2122.
29. Touboul PJ, HennericiMG, Meairs S, Adams H, Amarenco P, Desvarieux M, et al. Mannheim intima-media thickness consensus. Cerebrovasc Dis 2004; 18:346-349.
30. Corrado E, Rizzo M, Tantillo R, Muratori I, Bonura F, Vitale G, et al. Markers of inflammation and infection influence the outcome of patients with baseline asymptomatic carotid lesions: a 5-year follow-up study. Stroke 2006; 37:482-486.
31. Newman PJ, Derbes RS, Aster RH. The human platelet alloantigens, PlA1 and PlA2, are associated with a leucine33/proline33 amino acid polymorphism in membrane glycoprotein IIIa, and are distinguishable by DNA typing. J Clin Invest 1989; 83:1778-1781.
32. Walter DH, Schachinger V, Elsner M, Dimmeler S, Zeiher AM. Platelet glycoprotein IIIa polymorphisms and risk of coronary stent thrombosis. Lancet 1997; 350:1217-1219.
33. Brophy VH, Ro SK, Rhees BK, Lui LY, Lee JM, Umblas N, et al. Association of phosphodiesterase 4D polymorphisms with ischemic stroke in a US population stratified by hypertension status. Stroke 2006; 37:1385-1390.
34. Pontiggia L, Lassila R, Pederiva S, Schmid HR, Burger M, Beer JH. Increased platelet-collagen interaction associated with double homozygosity for receptor polymorphisms of platelet GPIa and GPIIIa. Arterioscler Thromb Vasc Biol 2002; 22:2093-2098.
35. Wheeler GL, Braden GA, Bray PF, Marciniak SJ, Mascelli MA, Sane DC. Reduced inhibition by abciximab in platelets with the PlA2 polymorphism. Am Heart J 2002; 143:76-82.
36. Papp E, Havasi V, Bene J, Komlosi K, Czopf L, Magyar E, et al. Glycoprotein IIIA gene (PlA) polymorphism and aspirin resistance: is there any correlation? Ann Pharmacother 2005; 39:1013-1018.