Novel axonal projection from the caudal end of the ventrolateral medulla to the intermediolateral cell column

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 292, Issue 2, 2007, Pages

  Iigaya, Kamon ^a   Kumagai, Hiroo ^a   Onimaru, Hiroshi ^b   Kawai, Akira ^b   Oshima, Naoki ^a   Onami, Toshiko ^a   Takimoto, Chie ^a   Kamayachi, Tadashi ^a   Hayashi, Koichi ^a   Saruta, Takao ^a   Itoh, Hiroshi ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b SHOWA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Caudal pressor area; Monosynaptic bulbospinal projection; Optical imaging; Patch clamp technique; Sympathetic nervous system

Indexed keywords

CALCIUM; DYE; GLUTAMIC ACID; MAGNESIUM;

ACTION POTENTIAL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIDROMIC STIMULATION; ARTICLE; BLOOD PRESSURE; BRAIN STEM; CELL STIMULATION; DEPOLARIZATION; ELECTROSTIMULATION; EXCITATORY POSTSYNAPTIC POTENTIAL; FLUORESCENCE; HYPERTENSION; IMAGING; LATENT PERIOD; MEDULLA OBLONGATA; NERVE CONDUCTION; NERVE FIBER; NERVE PROJECTION; NEWBORN; NONHUMAN; OPTICAL INSTRUMENTATION; PRIORITY JOURNAL; RAT; SPINAL CORD; SPINAL CORD NERVE CELL; STAINING; SYMPATHETIC NERVE; TH2 CELL; WISTAR KYOTO RAT;

ACTION POTENTIALS; ANIMALS; ANIMALS, NEWBORN; AXONS; BRAIN STEM; CALCIUM; ELECTRIC STIMULATION; ELECTROPHYSIOLOGY; EXCITATORY POSTSYNAPTIC POTENTIALS; GAMMA-AMINOBUTYRIC ACID; GLUTAMIC ACID; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNESIUM; MEDULLA OBLONGATA; NEURAL PATHWAYS; RATS; RATS, INBRED SHR; RATS, INBRED WKY; SPINAL CORD;

EID: 33846796285     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00254.2006     Document Type: Article

References (32)

1. Cabot J. Sympathetic preganglionic neurons: cytoarchitecture, ultrastructure and biophysical properties. In: Central Regulation of Autonomic Functions, edited by Loewy AD and Spyer KM. New York: Oxford Univ Press, 1990, p. 44-68.
2. Campos RR Jr, Possas OS, Cravo SL, Lopes OU, Guertzenstein PG. Putative pathways involved in cardiovascular responses evoked from the caudal pressor area. Braz J Med Biol Res 27: 2467-2479, 1994.
3. Chang Q, Gonzalez M, Pinter MJ, Balice-Gordon RJ. Gap junctional coupling and patterns of connexin expression among neonatal rat lumbar spinal motor neurons. J Neurosc 19: 10813-10828, 1999.
4. Dembowsky K, Czachurski J, Seller H. An intracellular study of the synaptic input to sympathetic preganglionic neurones of the third thoracic segment of the cat. J Appl Neurosci 13: 201-244, 1985.
5. Felten DL, Cummings JP. Ontogeny of medullary raphe nuclei in the rabbit brain stem: a Golgi study. Brain Res Bull 6: 413-425, 1981.
6. Haas HL, Jefferys JG. Low-calcium field burst discharges of CA1 pyramidal neurons in rat hippocampal slices. J Physiol 354: 185-201, 1984.
7. Hardy SG, Horecky JG, Presley KG. Projections of the caudal ventrolateral medulla to the thoracic spinal cord in the rat. Anat Rec 250: 95-102, 1998.
8. Horiuchi J, Saigusa T, Sugiyama N, Kanba S, Nishida Y, Sato Y, Hinuma S, Arita J. Effects of prolactin-releasing peptide microinjection into the ventrolateral medulla on arterial pressure and sympathetic activity in rats. Brain Res 958: 201-209, 2002.
9. Iigaya K, Kumagai H, Onimaru H, Kawai A, Oshima N, Onami T, Takimoto C, Saruta T. Optical imaging technique revealed a novel axonal projection from caudal end of ventrolateral medulla (VLM) to intermediolateral cell column (IML) in the sympathetic regulation (Abstract). Hypertension 46: 831, 2005.
10. Jansen AS, Wessendorf MW, Loewy AD. Transneuronal labeling of CNS neuropeptide and monoamine neurons after pseudorabies virus injections into the stellate ganglion. Brain Res 683: 1-24, 1995.
11. Li Q, Goodchild AK, Seyedabadi M, Pilowsky PM. Preprotachykinin A mRNA is colocalized with tyrosine hydroxylase-immunoreactivity in bulbospinal neurons. Neuroscience 136: 205-216, 2005.
12. Lipski J, Kawai Y, Qi J, Comer A, Win J. Whole cell patch-clamp study of putative vasomotor neurons isolated from the rostral ventrolateral medulla. Am J Physiol Regul Integr Comp Physiol 274: R1099-R1110, 1998.
13. Matsumoto M, Takayama K, Miura M. Distribution of glutamate- and GABA-immunoreactive neurons projecting to the vasomotor center of the intermediolateral nucleus of the lower thoracic cord of Wistar rats: a double-labeling study. Neurosci Lett 174: 165-816, 1994.
14. Matsuura T, Kumagai H, Kawai A, Onimaru H, Imai M, Oshima N, Sakata K, Saruta T. Rostral ventrolateral medulla neurons of neonatal Wistar-Kyoto and spontaneously hypertensive rats. Hypertension 40: 560-565, 2002.
15. Matsuura T, Kumagai H, Onimaru H, Kawai A, Iigaya K, Onami T, Sakata K, Oshima N, Sugaya T, Saruta T. Electrophysiological properties of rostral ventrolateral medulla neurons in angiotensin II 1a receptor knockout mice. Hypertension 46: 349-354, 2005.
16. Natarajan M, Morrison SF. Sympathoexcitatory CVLM neurons mediate responses to caudal pressor area stimulation. Am J Physiol Regul Integr Comp Physiol 279: R364-R374, 2000.
17. Onimaru H, Arata A, Homma I. Firing properties of respiratory rhythm generating neurons in the absence of synaptic transmission in rat medulla in vitro. Exp Brain Res 76: 530-536, 1989.
18. Onimaru H, Arata A, Homma I. Intrinsic burst generation of preinspiratory neurons in the medulla of brainstem-spinal cord preparations isolated from newborn rats. Exp Brain Res 106: 57-68, 1995.
19. Onimaru H, Homma I. A novel functional neuron group for respiratory rhythm generation in the ventral medulla. J Neurosci 23: 1478-1486, 2003.
20. Onimaru H, Homma I. Optical imaging of respiratory neuron activity from the dorsal view of the lower brainstem. Clin Exp Pharmacol Physiol 32: 297-301, 2005.
21. Oshima N, Kumagai H, Kawai A, Sakata K, Matsuura T, Saruta T. Three types of putative presympathetic neurons in the rostral ventrolateral medulla studied with rat brainstem-spinal cord preparation. Auton Neurosci 84: 40-49, 2000.
22. Otsuka M, Yanagisawa M. The effects of substance P and baclofen on motoneurones of isolated spinal cord of the newborn rat. J Exp Biol 89:201-214, 1980.
23. Pilowsky P, Llewellyn-Smith IJ, Arnolda L, Inson J, Chalmers J. Intracellular recording from sympathetic preganglionic neurons in cat lumbar spinal cord. Brain Res 656: 319-328, 1994.
24. Possas OS, Guertzenstein PG. A fall in arterial blood pressure produced by inhibition of the caudal most ventrolateral medulla: the caudal pressor area. J Auton Nerv Syst 49: 235-234, 1994.
25. Seyedabadi M, Li Q, Padley JR, Pilowsky PM, Goodchild AK. A novel pressor area at the medullo-cervical junction that is not dependent on the RVLM: efferent pathways and chemical mediators. J Neurosci 26: 5420-5427, 2006.
26. Strack AM, Sawyer WB, Hughes JH, Platt KB, Loewy AD. A general pattern of CNS innervation of the sympathetic outflow demonstrated by transneuronal pseudorabies viral infections. Brain Res 491: 156-162, 1989.
27. Sun W, Panneton WM. The caudal pressor area of the rat: its precise location and projections to the ventrolateral medulla. Am J Physiol Regul Integr Comp Physiol 283: R768-R778, 2002.
28. Sun W, Panneton WM. Defining projections from the caudal pressor area of the caudal ventrolateral medulla. J Comp Neurol 482: 273-293, 2005.
29. Sved AF, Ito S, Madden CJ, Stocker SD, Yajima Y. Excitatory inputs to the RVLM in the context of the baroreceptor reflex. Ann NY Acad Sci 940: 247-258, 2001.
30. Tokumasu M, Nakazono Y, Ide H, Akagawa K, Onimaru H. Optical recording of spontaneous respiratory neuron activity in the rat brain stem. Jpn J Physiol 51: 613-619, 2001.
31. Tominaga T, Tominaga Y, Ichikawa M. Simultaneous multi-site recordings of neural activity with an inline multi-electrode array and optical measurement in rat hippocampal slices. Pflugers Arch 443: 317-322, 2001.
32. Tominaga T, Tominaga Y, Ichikawa M. Optical imaging of long-lasting depolarization on burst stimulation in area CA1 of rat hippocampal slices. J Neurophysiol 88: 1523-1532, 2002.