Inhibition of lipopolysaccharid-induced sickness behavior by a dry extract from the roots of Pelargonium sidoides (EPs® 7630) in mice

Phytomedicine

Volumn 14, Issue SUPPL. 1, 2007, Pages 27-31

  Noldner M ^a   Schotz K ^a  

^a DR WILLMAR SCHWABE GMBH AND CO KG   (Germany)

Author keywords

LPS; Mice; Pelargonium sidoides; Sickness behavior

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CYTOKINE; EPS 7630; INTERLEUKIN 1BETA; INTERLEUKIN 6; PELARGONIUM SIDOIDES EXTRACT; PLANT EXTRACT; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANOREXIA; AQUEOUS SOLUTION; ARTICLE; CONTROLLED STUDY; DEPRESSION; DISEASE MODEL; DRUG EFFECT; DRUG EFFICACY; IMMUNE RESPONSE; INFECTION; LISTLESSNESS; MALAISE; MALE; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PELARGONIUM; PELARGONIUM SIDOIDES; PLANT ROOT; PRIORITY JOURNAL; SYMPTOM; TRADITIONAL MEDICINE; ULTRAFILTRATION;

ANIMALS; BEHAVIOR, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GRAM-NEGATIVE BACTERIA; LIPOPOLYSACCHARIDES; LIVER DISEASES; MALE; MICE; PELARGONIUM; PHYTOTHERAPY; PLANT EXTRACTS; PLANT ROOTS;

ANIMALIA; MUS; NEGIBACTERIA; PELARGONIUM SIDOIDES;

EID: 33846785451     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phymed.2006.11.013     Document Type: Article

References (9)

1. Berg B.M., Godbout J.P., Kelley K.W., and Johnson R.W. α-Tocopherol attenuates lipopolysaccharide-induced sickness behavior in mice. Brain Behav Immunity 18 (2004) 149-157
2. Castanon N., Bluthe R.M., and Dantzer R. Chronic treatment with the atypical antidepressant tianeptine attenuates sickness behaviour induced by peripheral but not central lipopolysaccharide and interleukin 1ß in the rat. Psychopharmacology 154 (2001) 50-60
3. Dantzer R. Cytokine-induced sickness behaviour: a neuroimmune response to activation of innate immunity. Eur J Pharmacol 500 (2004) 399-411
4. Kelley K.W., Bluthe R.M., Dantzer R., Zhou J.H., Shen W.H., Johnson R.W., and Broussard S.R. Cytokine-induced sickness behaviour. Brain Behavior Immunity 17 (2003) S112-S118
5. Nadjar A., Bluthe R.M., May M.J., Dantzer R., and Parnet P. Inactivation of the cerebral NFκB pathway inhibits interleukin-1β-induced sickness behavior and c-fos expression in various brain nuclei. Neuropsychopharmacology 30 (2005) 1492-1499
6. Parnet P., Kelley K.W., Bluthe R.M., and Dantzer R. Expression and regulation of interleukin-1 receptors in the brain. Role in cytokines-induced sickness behaviour. J Neuroimmunol 125 (2002) 5-14
7. Schiepers O.J.G., Wiechers M.C., and Maes M. Cytokines and major depression. Progr Neuro-Psychopharmacol Biol Psych 29 (2005) 201-217
8. Singal A., Tirkey N., Pilkhwal S., and Chopra K. Green tea (Camellia sinensis) extract ameliorates endotoxin induced sickness behavior and liver damage in rats. Phytother Res 20 (2006) 125-129
9. Watanabe S., Kanada S., Takenaka M., and Hamazaki T. Dietary n-3 fatty acids selectively attenuates LPS-induced behavioural depression in mice. Physiol Behav 81 (2004) 605-613