NMR simulation analysis of statistical effects on quantifying cerebrovascular parameters

Biophysical Journal

Volumn 92, Issue 3, 2007, Pages 1014-1021

  Klassen, L Martyn ^a,b   Menon, Ravi S ^a,b  

^a ROBARTS RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYHEMOGLOBIN;

ANALYTICAL PARAMETERS; ARTICLE; BLOOD VOLUME; MATHEMATICAL COMPUTING; MATHEMATICAL MODEL; NUCLEAR MAGNETIC RESONANCE; SIMULATION; TISSUE CULTURE;

EID: 33846782833     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1529/biophysj.106.087965     Document Type: Article

References (22)

1. Yablonskiy, D. A., and E. M. Haacke. 1994. Theory of NMR signal behavior in magnetically inhomogeneous tissues: the static dephasing regime. Magn. Reson. Med. 32:749-763.
2. An, H., and W. Lin. 2000. Quantitative measurements of cerebral blood oxygen saturation using magnetic resonance imaging. J. Cereb. Blood Flow Metab. 20:1225-1236.
3. Kiselev, V. G., and D. S. Novikov. 2002. Transverse NMR relaxation as a probe of mesoscopic structure. Phys. Rev. Lett. 89:278101.
4. Sukstanskii, A. L., and D. A. Yablonskiy. 2001. Theory of FID NMR signal dephasing induced by mesoscopic magnetic field inhomogeneities in biological systems. J. Magn. Reson. 151:107-117.
5. Yablonskiy, D. A. 1998. Quantitation of intrinsic magnetic susceptibility-related effects in a tissue matrix. Phantom study. Magn. Reson. Med. 39:417-428.
6. Sukstanskii, A. L., and D. A. Yablonskiy. 2003. Gaussian approximation in the theory of MR signal formation in the presence of structure-specific magnetic field inhomogeneities. J. Magn. Reson. 163:236-247.
7. Fujita, N. 2001. Extravascular contribution of blood oxygenation level-dependent signal changes: a numerical analysis based on a vascular network model. Magn. Reson. Med. 46:723-734.
8. Fujita, N., M. Shinohara, H. Tanaka, K. Yutani, H. Nakamura, and K. Murase. 2003. Quantitative mapping of cerebral deoxyhemoglobin content using MR imaging. Neuroimage. 20:2071-2083.
9. Ogawa, S., R. S. Menon, D. W. Tank, S. G. Kim, H. Merkle, J. M. Ellermann, and K. Ugurbil. 1993. Functional brain mapping by blood oxygenation level-dependent contrast magnetic resonance imaging. A comparison of signal characteristics with a biophysical model. Biophys. J. 64:803-812.
10. Boxerman, J. L., P. A. Bandettini, K. K. Kwong, J. R. Baker, T. L. Davis, B. R. Rosen, and R. M. Weisskoff. 1995. The intravascular contribution to fMRI signal change: Monte Carlo modeling and diffusion-weighted studies in vivo. Magn. Reson. Med. 34:4-10.
11. Kennan, R. P., J. Zhong, and J. C. Gore. 1994. Intravascular susceptibility contrast mechanisms in tissues. Magn. Reson. Med. 31:9-21.
12. Kiselev, V. G., and S. Posse. 1999. Analytical model of susceptibility-induced MR signal dephasing: effect of diffusion in a microvascular network. Magn. Reson. Med. 41:499-509.
13. Bandettini, P. A., and E. C. Wong. 1995. Effects of biophysical and physiological parameters on brain activation-induced R2* and R2 changes: simulations using a deterministic diffusion model. Int. J. Imag. Syst. Tech. 6:133-152.
14. Pauling, L., and C. D. Coryell. 1936. The magnetic properties and structure of hemoglobin, oxyhemoglobin and carbonmonoxyhemoglobin. Proc. Natl. Acad. Sci. USA. 22:210-216.
15. Spees, W. M., D. A. Yablonskiy, M. C. Oswood, and J. J. Ackerman. 2001. Water proton MR properties of human blood at 1.5 Tesla: magnetic susceptibility, T(1), T(2), T*(2), and non-Lorentzian signal behavior. Magn. Reson. Med. 45:533-542.
16. Silvennoinen, M. J., C. S. Clingman, X. Golay, R. A. Kauppinen, and P. C. van Zijl. 2003. Comparison of the dependence of blood R2 and R2* on oxygen saturation at 1.5 and 4.7 Tesla. Magn. Reson. Med. 49:47-60.
17. Hahn, E. L. 1950. Spin echoes. Phys. Rev. 80:580-594.
18. Haacke, E. M., R. W. Brown, M. R. Thompson, and R. Venkatesan. 1999. Magnetic Resonance Imaging: Physical Principles and Sequence Design. Wiley, New York.
19. Carr, H. Y., and E. M. Purcell. 1954. Effects of diffusion on free precession in nuclear magnetic resonance experiments. Phys. Rev. 94:630-638.
20. An, H., and W. Lin. 2003. Impact of intravascular signal on quantitative measures of cerebral oxygen extraction and blood volume under normo- and hypercapnic conditions using an asymmetric spin echo approach. Magn. Reson. Med. 50:708-716.
21. An, H., and W. Lin. 2002. Cerebral oxygen extraction fraction and cerebral venous blood volume measurements using MRI: effects of magnetic field variation. Magn. Reson. Med. 47:958-966.
22. Klassen, L. M., and R. S. Menon. 2002. Non-invasive absolute deoxyhemoglobin concentration measurement using high field MRI and near infrared spectroscopy. Proc. 13th ISMRM. 1342.