Lamotrigine-induced Stevens-Johnson syndrome

American Journal of Health-System Pharmacy

Volumn 64, Issue 3, 2007, Pages 273-275

  Hilas, Olga ^a   Charneski, Lisa ^a  

^a ST JOHN'S UNIVERSITY   (United States)

Author keywords

Alkalinizing agents; Anesthetics, local; Anticonvulsants; Antihistamines; Aripiprazole; Diphenhydramine; Dosage; Escitalopram; Hydroxyzine; Lamotrigine; Lidocaine; Lubricants; Patient information; Petrolatum; Prednisone; Sodium bicarbonate; Steroids, cortico

Indexed keywords

ARIPIPRAZOLE; BICARBONATE; DIPHENHYDRAMINE; ESCITALOPRAM; HYDROXYZINE; INFUSION FLUID; LAMOTRIGINE; LIDOCAINE; PETROLATUM; PREDNISONE;

ADULT; ARTICLE; CASE REPORT; CLINICAL FEATURE; DRUG WITHDRAWAL; EMERGENCY CARE; ERYTHEMA; FEMALE; HOSPITAL DISCHARGE; HUMAN; LIP DISEASE; MOUTH PAIN; MOUTHWASH; PATIENT EDUCATION; PRIORITY JOURNAL; PRURITUS; PUNCH BIOPSY; RASH; SCHIZOAFFECTIVE PSYCHOSIS; SKIN IRRITATION; SKIN MANIFESTATION; STEVENS JOHNSON SYNDROME;

EID: 33846705029     PISSN: 10792082     EISSN: None     Source Type: Journal    
DOI: 10.2146/ajhp060071     Document Type: Article

References (16)

1. Lamictal (lamotrigine) package insert. Greenville, NC: GlaxoSmithKline; 2005 Aug.
2. Goldsmith DR, Wagstaff AJ, Ibbotson T et al. Lamotrigine: a review of its use in bipolar disorder. Drugs. 2003; 63:2029-50.
3. Naranjo CA, Busto U, Sellers EM et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther. 1981; 30:239-45.
4. Calabrese JR, Sullivan JR, Bowden CL et al. Rash in multicenter trials of lamotrigine in mood disorders: clinical relevance and management. J Clin Psychiatry. 2002; 63:1012-9.
5. Letko E, Papaliodis DN, Papaliodis GN et al. Stevens-Johnson syndrome and toxic epidermal necrolysis: a review of the literature. Ann Allergy Asthma Immunol. 2005; 94:419-36.
6. Warnock JK, Morris DW. Adverse cutaneous reactions to mood stabilizers. Am J Clin Dermatol. 2003; 4:21-30.
7. Roujeau JC, Kelly JP, Naldi L et al. Medication use and the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis. N Engl J Med. 1995; 333:1600-7.
8. Rzany B, Correia O, Kelly JP et al. Risk of Stevens-Johnson syndrome and toxic epidermal necrolysis during first weeks of antiepileptic therapy: a case-control study. Lancet. 1999; 353:2190-4.
9. Guberman AH, Besag FM, Brodie MJ et al. Lamotrigine-associated rash: risk/benefit considerations in adults and children. Epilepsia. 1999; 40:985-91.
10. Herbert AA, Ralston JP. Cutaneous reactions to anticonvulsant medications. J Clin Psychiatry. 2001; 62(suppl 14):22-6.
11. Habif TP. Clinical dermatology: a color guide to diagnosis and therapy. 4th ed. St. Louis: Mosby; 2004:630-4.
12. Yalcin B, Karaduman A. Stevens-Johnson syndrome associated with concomitant use of lamotrigine and valproic acid. J Am Acad Dermatol. 2000; 43:898-9.
13. Schlienger RG, Shapiro LE, Shear NH. Lamotrigine-induced severe cutaneous reactions. Epilepsia. 1998; 39(suppl 7):S22-6.
14. Page RL, O'Neil MG, Yarbrough DR et al. Fatal toxic epidermal necrolysis related to lamotrigine administration. Pharmacotherapy. 1998; 18:392-8.
15. Chaffin JJ, Davis SM. Suspected lamotrigine-induced toxic epidermal necrolysis. Ann Pharmacother. 1997; 6:720-3.
16. Varghese SP, Haith LR, Patton ML et al. Lamotrigine-induced toxic epidermal necrolysis in three patients treated for bipolar disorder. Pharmacotherapy. 2006; 26:699-704.