Distribution of the HIV resistance CCR5-Δ32 allele among Egyptians and Syrians

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 616, Issue 1-2, 2007, Pages 175-180

  Salem, Abdel Halim ^a,b   Batzer, Mark A ^a  

^a Center for BioModular Multi Scale Systems   (United States)

^b Suez Canal University Faculty of Medicine   (Egypt)

Author keywords

Chemokine receptor; Human immunodeficiency virus type 1; Polymorphisms

Indexed keywords

CHEMOKINE RECEPTOR CCR5;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; AGAR GEL ELECTROPHORESIS; ARTICLE; CELL INVASION; DISEASE RESISTANCE; EGYPTIAN; ETHNIC GROUP; GENE DELETION; GENE FREQUENCY; GENETIC POLYMORPHISM; GENOTYPE; HETEROZYGOTE; HIGH RISK POPULATION; HOMOZYGOTE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SEXUALLY TRANSMITTED DISEASE; SYRIAN;

ALLELES; EGYPT; GENE FREQUENCY; GENOTYPE; HIV INFECTIONS; HUMANS; IMMUNITY, NATURAL; POLYMERASE CHAIN REACTION; RECEPTORS, CCR5; SEQUENCE DELETION; SYRIA;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 33846669025     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2006.11.024     Document Type: Article

References (56)

1. Liu R., Paxton W.A., Choe S., Ceradini D., Martin S.R., Horuk R., MacDonald M.E., Stuhlmann H., Koup R.A., and Landau N.R. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell 86 (1996) 367-377
2. Samson M., Libert F., Doranz B.J., Rucker J., Liesnard C., Farber C.M., Saragosti S., Lapoumeroulie C., Cognaux J., Forceille C., Muyldermans G., Verhofstede C., Burtonboy G., Georges M., Imai T., Rana S., Yi Y., Smyth R.J., Collman R.G., Doms R.W., Vassart G., and Parmentier M. Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. Nature 382 (1996) 722-725
3. Dean M., Carrington M., Winkler C., Huttley G.A., Smith M.W., Allikmets R., Goedert J.J., Buchbinder S.P., Vittinghoff E., Gomperts E., Donfield S., Vlahov D., Kaslow R., Saah A., Rinaldo C., Detels R., and O'Brien S.J. Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Hemophilia Growth and Development Study, Multicenter AIDS Cohort Study, Multicenter Hemophilia Cohort Study, San Francisco City Cohort, ALIVE Study. Science 273 (1996) 1856-1862
4. Paxton W.A., Martin S.R., Tse D., O'Brien T.R., Skurnick J., VanDevanter N.L., Padian N., Braun J.F., Kotler D.P., Wolinsky S.M., and Koup R.A. Relative resistance to HIV-1 infection of CD4 lymphocytes from persons who remain uninfected despite multiple high-risk sexual exposure. Nat. Med. 2 (1996) 412-417
5. Biti R., Ffrench R., Young J., Bennetts B., Stewart G., and Liang T. HIV-1 infection in an individual homozygous for the CCR5 deletion allele. Nat. Med. 3 (1997) 252-253
6. Hasan M.A., Farag A.B., and Ismail M.A. AIDS and intravenous drug users in Egypt. Proceedings of the Tenth International Conference on AIDS. Yokohama, Japan (1994)
7. Watts D.M., Constantine N.T., Sheba M.F., Kamal M., Callahan J.D., and Kilpatrick M.E. Prevalence of HIV infection and AIDS in Egypt over 4 years of surveillance (1986-1990). J. Trop. Med. Hyg. 96 (1993) 113-117
8. P.N. Shrestha, Forthcoming WER Global Update of AIDS Cases Reported to WHO, WHO/EMRO/ASD, 1999.
9. Sadek A.S., Bassily M., and Bishai M. Human immunodeficiency virus and other sexually transmitted pathogens among std patients in Cairo, Egypt. Proceedings of the VII International Conference on AIDS. Florence, Italy (1991)
10. Murphy P.M. Chemokine receptors: structure, function and role in microbial pathogenesis. Cytokine Growth Factor Rev. 7 (1996) 47-64
11. Libert F., Cochaux P., Beckman G., Samson M., Aksenova M., Cao A., Czeizel A., Claustres M., de laRua C., Ferrari M., Ferrec C., Glover G., Grinde B., Guran S., Kucinskas V., Lavinha J., Mercier B., Ogur G., Peltonen L., Rosatelli C., Schwartz M., Spitsyn V., Timar L., Beckman L., Vassart G., et al. The deltaccr5 mutation conferring protection against HIV-1 in Caucasian populations has a single and recent origin in Northeastern Europe. Hum. Mol. Genet. 7 (1998) 399-406
12. Hill C.M., and Littman D.R. Natural resistance to HIV?. Nature 382 (1996) 668-669
13. Fauci A.S. Resistance to HIV-1 infection: it's in the genes. Nat. Med. 2 (1996) 966-967
14. Neote K., DiGregorio D., Mak J.Y., Horuk R., and Schall T.J. Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor. Cell 72 (1993) 415-425
15. Samson M., Labbe O., Mollereau C., Vassart G., and Parmentier M. Molecular cloning and functional expression of a new human CC-chemokine receptor gene. Biochemistry 35 (1996) 3362-3367
16. Murphy P.M. The molecular biology of leukocyte chemoattractant receptors. Annu. Rev. Immunol. 12 (1994) 593-633
17. Alkhatib G., Combadiere C., Broder C.C., Feng Y., Kennedy P.E., Murphy P.M., and Berger E.A. CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1. Science 272 (1996) 1955-1958
18. Choe H., Farzan M., Sun Y., Sullivan N., Rollins B., Ponath P.D., Wu L., Mackay C.R., LaRosa G., Newman W., Gerard N., Gerard C., and Sodroski J. The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. Cell 85 (1996) 1135-1148
19. Deng H., Liu R., Ellmeier W., Choe S., Unutmaz D., Burkhart M., Di Marzio P., Marmon S., Sutton R.E., Hill C.M., Davis C.B., Peiper S.C., Schall T.J., Littman D.R., and Landau N.R. Identification of a major co-receptor for primary isolates of HIV-1. Nature 381 (1996) 661-666
20. Doranz B.J., Rucker J., Yi Y., Smyth R.J., Samson M., Peiper S.C., Parmentier M., Collman R.G., and Doms R.W. A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors. Cell 85 (1996) 1149-1158
21. Dragic T., Litwin V., Allaway G.P., Martin S.R., Huang Y., Nagashima K.A., Cayanan C., Maddon P.J., Koup R.A., Moore J.P., and Paxton W.A. HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5. Nature 381 (1996) 667-673
22. McNicholl J.M., Smith D.K., Qari S.H., and Hodge T. Host genes and HIV: the role of the chemokine receptor gene CCR5 and its allele. Emerg. Infect. Dis. 3 (1997) 261-271
23. Huang Y., Paxton W.A., Wolinsky S.M., Neumann A.U., Zhang L., He T., Kang S., Ceradini D., Jin Z., Yazdanbakhsh K., Kunstman K., Erickson D., Dragon E., Landau N.R., Phair J., Ho D.D., and Koup R.A. The role of a mutant CCR5 allele in HIV-1 transmission and disease progression. Nat. Med. 2 (1996) 1240-1243
24. Michael N.L., Chang G., Louie L.G., Mascola J.R., Dondero D., Birx D.L., and Sheppard H.W. The role of viral phenotype and CCR-5 gene defects in HIV-1 transmission and disease progression. Nat. Med. 3 (1997) 338-340
25. Eugen-Olsen J., Iversen A.K., Garred P., Koppelhus U., Pedersen C., Benfield T.L., Sorensen A.M., Katzenstein T., Dickmeiss E., Gerstoft J., Skinhoj P., Svejgaard A., Nielsen J.O., and Hofmann B. Heterozygosity for a deletion in the CKR-5 gene leads to prolonged AIDS-free survival and slower CD4 T-cell decline in a cohort of HIV-seropositive individuals. AIDS 11 (1997) 305-310
26. Hoffman T.L., MacGregor R.R., Burger H., Mick R., Doms R.W., and Collman R.G. CCR5 genotypes in sexually active couples discordant for human immunodeficiency virus type 1 infection status. J. Infect. Dis. 176 (1997) 1093-1096
27. Martinson J.J., Chapman N.H., Rees D.C., Liu Y.T., and Clegg J.B. Global distribution of the CCR5 gene 32-basepair deletion. Nat. Genet. 16 (1997) 100-103
28. Magierowska M., Lepage V., Boubnova L., Carcassi C., de Juan D., Djoulah S., El Chenawi F., Grunnet N., Halle L., Ivanova R., Jungerman M., Naumova E., Petrany G., Sonnerborg A., Stavropoulos C., Thorsby E., Vu-Trieu A., Debre P., Theodorou I., and Charron D. Distribution of the CCR5 gene 32 base pair deletion and SDF1-3′A variant in healthy individuals from different populations. Immunogenetics 48 (1998) 417-419
29. Lu Y., Nerurkar V.R., Dashwood W.M., Woodward C.L., Ablan S., Shikuma C.M., Grandinetti A., Chang H., Nguyen H.T., Wu Z., Yamamura Y., Boto W.O., Merriwether A., Kurata T., Detels R., and Yanagihara R. Genotype and allele frequency of a 32-base pair deletion mutation in the CCR5 gene in various ethnic groups: absence of mutation among Asians and Pacific Islanders. Int. J. Infect. Dis. 3 (1999) 186-191
30. Diaz F.J., Vega J.A., Patino P.J., Bedoya G., Nagles J., Villegas C., Vesga R., and Rugeles M.T. Frequency of CCR5 delta-32 mutation in human immunodeficiency virus (HIV)-seropositive and HIV-exposed seronegative individuals and in general population of Medellin, Colombia. Mem. Inst. Oswaldo Cruz 95 (2000) 237-242
31. Stephens J.C., Reich D.E., Goldstein D.B., Shin H.D., Smith M.W., Carrington M., Winkler C., Huttley G.A., Allikmets R., Schriml L., Gerrard B., Malasky M., Ramos M.D., Morlot S., Tzetis M., Oddoux C., di Giovine F.S., Nasioulas G., Chandler D., Aseev M., Hanson M., Kalaydjieva L., Glavac D., Gasparini P., Dean M., et al. Dating the origin of the CCR5-Delta32 AIDS-resistance allele by the coalescence of haplotypes. Am. J. Hum. Genet. 62 (1998) 1507-1515
32. Slatkin M. Simulating genealogies of selected alleles in a population of variable size. Genet. Res. 78 (2001) 49-57
33. Hummel S., Schmidt D., Kremeyer B., Herrmann B., and Oppermann M. Detection of the CCR5-Delta32 HIV resistance gene in bronze age skeletons. Genes Immunol. 6 (2005) 371-374
34. de Silva E., and Stumpf M.P. HIV and the CCR5-Delta32 resistance allele. FEMS Microbiol. Lett. 241 (2004) 1-12
35. Stumpf M.P., and Wilkinson-Herbots H.M. Allelic histories: positive selection on a HIV-resistance allele. Trends Ecol. Evol. 19 (2004) 166-168
36. Galvani A.P., and Novembre J. The evolutionary history of the CCR5-Delta32 HIV-resistance mutation. Microbes Infect. 7 (2005) 302-309
37. Novembre J., Galvani A.P., and Slatkin M. The geographic spread of the CCR5 Delta32 HIV-resistance allele. PLoS Biol. 3 (2005) e339
38. Stoneking M., Fontius J.J., Clifford S.L., Soodyall H., Arcot S.S., Saha N., Jenkins T., Tahir M.A., Deininger P.L., and Batzer M.A. Alu insertion polymorphisms and human evolution: evidence for a larger population size in Africa. Genome Res. 7 (1997) 1061-1071
39. Salem A.H., Ray D.A., and Batzer M.A. Identity by descent and DNA sequence variation of human SINE and LINE elements. Cytogenet. Genome Res. 108 (2005) 63-72
40. Sambrook J., Fritsch E.F., and Maniatus T. Molecular Cloning: A laboratory Manual (1989), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
41. Sanger F., Nicklen S., and Coulson A.R. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. U.S.A. 74 (1977) 5463-5467
42. Voevodin A., Samilchuk E., and Dashti S. A survey for 32 nucleotide deletion in the CCR-5 chemokine receptor gene (deltaccr-5) conferring resistance to human immunodeficiency virus type 1 in different ethnic groups and in chimpanzees. J. Med. Virol. 55 (1998) 147-151
43. O'Brien T.R., Winkler C., Dean M., Nelson J.A., Carrington M., Michael N.L., and White G.C. 2nd HIV-1 infection in a man homozygous for CCR5 delta 32. Lancet 349 (1997) 1219
44. Theodorou I., Meyer L., Magierowska M., Katlama C., and Rouzioux C. HIV-1 infection in an individual homozygous for CCR5 delta 32. Seroco Study Group. Lancet 349 (1997) 1219-1220
45. Berger E.A., Murphy P.M., and Farber J.M. Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and disease. Annu. Rev. Immunol. 17 (1999) 657-700
46. Smith M.W., Dean M., Carrington M., Winkler C., Huttley G.A., Lomb D.A., Goedert J.J., O'Brien T.R., Jacobson L.P., Kaslow R., Buchbinder S., Vittinghoff E., Vlahov D., Hoots K., Hilgartner M.W., and O'Brien S.J. Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1 infection and disease progression. Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS), San Francisco City Cohort (SFCC), ALIVE Study. Science 277 (1997) 959-965
47. Winkler C., Modi W., Smith M.W., Nelson G.W., Wu X., Carrington M., Dean M., Honjo T., Tashiro K., Yabe D., Buchbinder S., Vittinghoff E., Goedert J.J., O'Brien T.R., Jacobson L.P., Detels R., Donfield S., Willoughby A., Gomperts E., Vlahov D., Phair J., and O'Brien S.J. Genetic restriction of AIDS pathogenesis by an SDF-1 chemokine gene variant. ALIVE Study, Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS), San Francisco City Cohort (SFCC). Science 279 (1998) 389-393
48. Deng H.K., Unutmaz D., KewalRamani V.N., and Littman D.R. Expression cloning of new receptors used by simian and human immunodeficiency viruses. Nature 388 (1997) 296-300
49. Lalani A.S., Masters J., Zeng W., Barrett J., Pannu R., Everett H., Arendt C.W., and McFadden G. Use of chemokine receptors by poxviruses. Science 286 (1999) 1968-1971
50. Galvani A.P., and Slatkin M. Evaluating plague and smallpox as historical selective pressures for the CCR5-delta 32 HIV-resistance allele. Proc. Natl. Acad. Sci. U.S.A. 100 (2003) 15276-15279
51. Lenski R.E. Evolution of plague virulence. Nature 334 (1988) 473-474
52. McEvedy C. The bubonic plague. Sci. Am. 258 (1988) 118-123
53. Klitz W., Brautbar C., Schito A.M., Barcellos L.F., and Oksenberg J.R. Evolution of the CCR5 Delta32 mutation based on haplotype variation in Jewish and Northern European population samples. Hum. Immunol. 62 (2001) 530-538
54. Easterbrook P.J., Chmiel J.S., Hoover D.R., Saah A.J., Kaslow R.A., Kingsley L.A., and Detels R. Racial and ethnic differences in human immunodeficiency virus type 1 (HIV-1) seroprevalence among homosexual and bisexual men. The Multicenter AIDS Cohort Study. Am. J. Epidemiol. 138 (1993) 415-429
55. Soto-Ramirez L.E., Renjifo B., McLane M.F., Marlink R., O'Hara C., Sutthent R., Wasi C., Vithayasai P., Vithayasai V., Apichartpiyakul C., Auewarakul P., Pena Cruz V., Chui D.S., Osathanondh R., Mayer K., Lee T.H., and Essex M. HIV-1 Langerhans' cell tropism associated with heterosexual transmission of HIV. Science 271 (1996) 1291-1293
56. Su B., Sun G., Lu D., Xiao J., Hu F., Chakraborty R., Deka R., and Jin L. Distribution of three HIV-1 resistance-conferring polymorphisms (SDF1-3′A, CCR2-641, and CCR5-delta32) in global populations. Eur. J. Hum. Genet. 8 (2000) 975-979