Lanthanum carbonate - New data on parathyroid hormone control without liver damage

Nephrology Dialysis Transplantation

Volumn 22, Issue 2, 2007, Pages 316-318

  Cozzolino, Mario ^a   Brancaccio, Diego ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

Chronic kidney disease; Lanthanum carbonate; Phosphate; Phosphate binders; Secondary hyperparathyroidism

Indexed keywords

LANTHANUM CARBONATE; PARATHYROID HORMONE; PHOSPHATE; PHOSPHATE BINDING AGENT; SEVELAMER;

ARTICLE; BLOOD SAMPLING; BLOOD VESSEL CALCIFICATION; CHRONIC KIDNEY DISEASE; CHRONIC KIDNEY FAILURE; DRUG LIVER LEVEL; HORMONAL REGULATION; HYPERPHOSPHATEMIA; LIVER INJURY; LIVER TOXICITY; LIVER WEIGHT; MICROSCOPY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PARATHYROID HORMONE RELEASE; PARATHYROID HYPERPLASIA; PHOSPHATE BLOOD LEVEL; PRIORITY JOURNAL; SECONDARY HYPERPARATHYROIDISM; URINALYSIS;

HUMANS; KIDNEY FAILURE, CHRONIC; LANTHANUM; NEPHRECTOMY; PARATHYROID HORMONE; PHOSPHORUS METABOLISM DISORDERS; TREATMENT OUTCOME;

EID: 33846668835     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfl720     Document Type: Article

References (22)

1. Block GA, Klassen PS, Lazarus JM et al. Mineral metabolism, mortality, and morbidity in maintenance hemodialysis. J Am Soc Nephrol 2004; 15: 2208-2218
2. 4 product, and parathyroid hormone with cardiac mortality risk in chronic hemodialysis patients. J Am Soc Nephrol 2001; 12: 2131-2138
3. Delmez JA, Slatopolsky E. Hyperphosphatemia: Its consequences and treatment in patients with chronic renal disease. Am J Kidney Dis 1992; 19: 303-317
4. Nielsen PK, Feldt-Rasmussen U, Olgaard K. A direct effect in vitro of phosphate on PTH release from bovine parathroid tissue slices but not from dispersed parathyroid cells. Nephrol Dial Transplant 1996; 11: 1762-1768
5. Cozzolino M, Lu Y, Sato T et al. A critical role for enhanced-TGFα and EGFR expression in the initiation of parathyroid hyperplasia in experimental renal disease. Am J Physiol Renal Physiol 2005; 289: F1096-F1102
6. Moallem E, Kilav R, Silver J, Naveh-Many T. RNA-Protein binding and post-transcriptional regulation of parathyroid hormone gene expression by calcium and phosphate. J Biol Chem 1998; 273: 5253-5259
7. Wang Q, Palnitkar S, Parfitt AM. Parathyroid cell proliferation in normal human parathyroid tissue: Implications for the pathogenesis of hyperparathyroidism. Clin Endocrinol 1997; 46: 343-349
8. Silver J, Bar Sela S, Naveh-Many T. Regulation of parathyroid cell proliferation. Curr Op Nephrol Hyperten 1997; 6: 321-326
9. Cozzolino M, Dusso A, Slatopolsky E. Role of calcium x phosphate product and bone associated proteins on vascular calcification in renal failure. J Am Soc Nephrol 2001; 12: 2511-2516
10. Jono S, McKee MD, Murry CE et al. Phosphate regulation of vascular smooth muscle cell calcification. Circ Res 2000; 87: E10-E17
11. Cozzolino M, Brancaccio D, Gallieni M, Slatopolsky E. Pathogenesis of vascular calcification in chronic kidney disease. Kidney Int 2005; 68: 429-436
12. Ben-Dov IZ, Pappo O, Sklair-Leyy M et al. Lanthanum carbonate decreases PTH gene expression with no hepatotoxicity in uremic rats. Nephrol Dial Transplant 7 Nov 2006 [Epub ahead of print]
13. Ksatumata K, Kusano K, Hirata M et al. Sevelamer hydrochloride prevents ectopic calcification and renal osteodystrophy in chronic renal failure rats. Kidney Int 2003; 64: 441-450
14. Nagano N, Miyata S, Obana S et al. Sevelamer hydrochloride, a clacium-free phosphate-binder, inhibits parathyroid cell proliferation in partially nephrectomized rats. Nephrol Dial Transplant 2003; 18 [Suppl 3]: Ii81-ii85
15. Cozzolino M, Dusso A, Liapis H et al. The effects of sevelamer hydrochloride and calcium carbonate on kidney calcification in uremic rats. J Am Soc Nephrol 2002; 13: 2299-2308
16. Lacour B, Lucas A, Auchèere D et al. Chronic renal failure is associated with increased tissue deposition of lanthanum after 28-days oral administration. Kidney Int 2005; 67: 1062-1069
17. Slatopolsky E, Liapis H, Finch J. Progressive accumulation of lanthanum in the liver of normal and uremic rats. Kidney Int 2005; 68: 2809-2813
18. McLeod C, Cox A, Bramall N. The need for contamination control in studies on lanthanum biodisposition. Kidney Int 2005; 68: 2906
19. Rambeck W. The need for careful interpretation of animal data on lanthanum. Kidney Int 2005; 68: 2909
20. Damment SP. Enlightenment on liver lanthanum exposure. Kidney Int 2006; 70: 1372-1373
21. Yang Z, Schryvers D, Roels F et al. Demonstration of lanthanum in liver cells by energy-dispersive X-ray spectroscopy and high-resolution transmission electron microscopy. J Microsc 2006; 223: 133-139
22. Hutchison AJ, Maes B, Vanwalleghem J et al. Long-term efficacy and tolerability of lanthanum carbonate: Results from a 3-year study. Nephron Clin Pract 2006; 102: C61-c71