Alterations in the endothelial G-protein coupled receptor pathway in epicardial arteries and subendocardial arterioles incompensated left ventricular hypertrophy

Basic Research in Cardiology

Volumn 102, Issue 2, 2007, Pages 144-153

  Aubin, Marie Claude ^a   Gendron, Marie Eve ^a   Lebel, Vickie ^a   Thorin, Éric ^a   Tardif, Jean Claude ^a   Carrier, Michel ^a   Perrault, Louis P ^a  

^a MONTREAL HEART INSTITUTE   (Canada)

Author keywords

Coronary circulation; Endothelial dysfunction; G proteins; Left ventricular hypertrophy; Microcirculation

Indexed keywords

BRIMONIDINE; ENDOTHELIUM DERIVED RELAXING FACTOR; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; NITROPRUSSIDE SODIUM; SEROTONIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY ENDOTHELIUM; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; ECHOCARDIOGRAPHY; ENDOTHELIAL DYSFUNCTION; HEART LEFT VENTRICLE HYPERTROPHY; MALE; MICROCIRCULATION; MYOGRAPHY; NONHUMAN; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SWINE; VASODILATATION;

ANIMALS; ARTERIOLES; BIOLOGICAL FACTORS; CORONARY VESSELS; ECHOCARDIOGRAPHY; ENDOTHELIUM, VASCULAR; GTP-BINDING PROTEINS; HYPERTROPHY, LEFT VENTRICULAR; MALE; NITRIC OXIDE; SIGNAL TRANSDUCTION; SWINE; VASODILATION;

EID: 33846659115     PISSN: 03008428     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00395-006-0626-z     Document Type: Article

References (19)

1. Bishop SP, Powell PC, Hasebe N, Shen YT, Patrick TA, Hittinger L, Vatner SF (1996) Coronary vascular morphology in pressure-overload left ventricular hypertrophy. J Mol Cell Cardiol 28:141-154
2. Brown DW, Giles WH, Croft JB (2000)Left ventricular hypertrophy as a predictor of coronary heart disease mortality and the effect of hypertension. Am Heart J 140:848-856
3. Campbell WB, Gauthier KM (2002)What is new in endothelium-derived hyperpolarizing factors? Curr Opin Nephrol Hypertens Res 11:177-183
4. Desjardins F, Aubin MC, Carrier M, PerraultLP (2005) Decrease of endothelin receptor subtype ETB and release of COX-derived products contribute to endothelial dysfunction of porcine coronary arteries in left ventricular hypertrophy. J Cardiovasc Pharmacol 45:499-508
5. Gendron ME, Thorin E, Perrault LP(2004) Loss of endothelial K ATP channel-dependent, NO-mediated dilationof endocardial resistance coronary arteriesin pigs with left ventricular hypertrophy.Br J Pharmacol 143:285-291
6. Ghaleh B, Hittinger L, Kim SJ, Kudej RK, Iwase M, Uechi M, Berdeaux A, Bishop SP, Vatner SF (1998) Selective large coronary endothelial dysfunction in conscious dogs with chronic coronary pressure overload. Am J Physiol 274:H539-H551
7. Kingsbury MP, Turner MA, Flores NA,Bovill E, Sheridan DJ (2000) Endogenous and exogenous coronary vasodilatations are attenuated in cardiac hypertrophy: A morphological defect? J Mol Cell Cardiol 32:527-538
8. Komozi K, Vanhoutte PM (1990) Endothelium-derived hyperpolarizing factor.Blood Vessels 27:238-245
9. Küng CF, Tschudi MR, Noll G, Clozel JP,Lüscher TF (1995) Effects of the calcium-antagonist mibefradil in epicardial and intramyocardial coronary arteries.J Cardiovasc Pharmacol 26:312-318
10. Malo O, Carrier M, Shi YF, Tardif JC,Tanguay JF, Perrault LP (2003) Specific alterations of endothelial signal transduction pathways of porcine epicardialcoronary arteries in left ventricular hypertrophy.J Cardiovasc Pharmacol 42:275-286
11. Maron BJ, Wolfson JK, Epstein SE,Roberts WC (1986) Intramural ("small vessel") coronary artery disease in hypertrophic cardiomyopathy. J Am Coll Cardiol 8:545-557
12. Nagao T, Illiano S, Vanhoutte PM (1992) Heterogeneous distribution of endothelium-dependent relaxations resistant to nitro-L-arginine in the arterial tree of the rat. Am J Physiol 263:90-94
13. Schiffrin EL (1994) The endothelium and the control of blood vessel function in health and disease. Clin Invest Med 17:602-620
14. Schwartzkopff B, Frenzel H, Dieckerhoff J, Betz P, Flasshove M, Schulte HD, Mundhenke M, Motz W, Strauer BE(1992) Morphometric investigation of human myocardium in arterial hypertension and valvular aortic stenosis. Eur Heart J 13:17-23
15. Taniyama Y, Griendling KK (2003) Reactive oxygen species in the vasculature. Molecular and cellular mechanism. Hypertension 23:8019-8029
16. Titcomb CP Jr (2004) LVH: Consequencesassociated with cardiac remodelling.J Insur Med 36:42-46
17. Vanhoutte PM (2001) Endothelial dysfunction and vascular disease. In: Gupta SK (ed) Pharmacology and Therapeutics in the New Millenium. Narosa Publishing House, New Delhi, pp 1-17
18. Véquaud P, Thorin E (2001) Endothelial G protein beta-subunits trigger nitric oxide but not endothelium-derived hyperpolarizing factor-dependent dilation in rabbit resistance arteries. Circ Res 89:716-722
19. Yamori Y, Mori C, Nishio T, Ooshima A, Horie R, Ohtaka M, Soeda T, Saito M, Abe K, Nara Y, Nakao Y, Kihara M (1979) Cardiac hypertrophy in early hypertension. Am J Cardiol 44:964-969