Isolation and characterisation of impurities in adapalene

Journal of Pharmaceutical and Biomedical Analysis

Volumn 43, Issue 3, 2007, Pages 1161-1163

  Brenna, Elisabetta ^a   Frigoli, Samuele ^a   Fronza, Giovanni ^a   Fuganti, Claudio ^a   Sala, Federico ^a  

^a CNR   (Italy)

Author keywords

Adapalene; Impurity; Isolation; Structural characterisation

Indexed keywords

4 BROMOANISOLE; ADAMANTANE DERIVATIVE; ADAMANTANOL; ADAPALENE; ANISOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CROSS COUPLING REACTION; DRUG DETERMINATION; DRUG IMPURITY; DRUG ISOLATION; DRUG PURIFICATION; DRUG STRUCTURE; DRUG SYNTHESIS; FRIEDEL CRAFTS REACTION; NEGISHI COUPLING; PRIORITY JOURNAL; PROCESS OPTIMIZATION; REACTION ANALYSIS;

CRYSTALLIZATION; DERMATOLOGIC AGENTS; DRUG CONTAMINATION; INDICATORS AND REAGENTS; MAGNETIC RESONANCE SPECTROSCOPY; NAPHTHALENES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 33846645999     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2006.09.035     Document Type: Article

References (11)

1. Gudas L.J., Sporn M.B., and Roberts A.B. In: Sporn M.B., Roberts A.B., and Goodman D.S. (Eds). The Retinoids, Biology, Chemistry and Medicine (1994), Raven Press, New York 443-520
2. Boyd A.S. Am. J. Med. 86 (1989) 568-574
3. Chomienne C., Ballerini P., Balitrand N., Amor M., Bernard J.F., Boivin P., Daniel M.T., Berger R., Castaigne S., and Degos L. Lancet ii (1994) 746-747
4. Charpentier B., Bernardon J.-M., Eustache J., Millois C., Martin B., Michel S., and Shroot B. J. Med. Chem. 38 (1995) 4993-5006
5. Shroot B., and Michel S. J. Am. Acad. Dermatol. 36 (1997) S96-S103
6. B. Shroot, J. Eustache, J.M. Bernardon, U.S. Patent 4,717,720, 1988.
7. B. Shroot, J. Eustache, J.M. Bernardon, EP 199636 B1, 1989.
8. Liu Z., and Xiang L. Org. Process. Res. Dev. 10 (2006) 285-288
9. Newman H. Synthesis (1972) 692-693
10. Chalais S., Cornelis A., Getsmans A., Kolodziejski W., Laszlo P., Mathy A., and Metra P. Helv. Chim. Acta 68 (1985) 1196-1203
11. Negishi E. Acc. Chem. Res. 15 (1982) 340-348