Stable pattern of HIV-1 subtype C Gag-specific T-cell responses coincides with slow rate of CD4 T-cell decline in HIV-infected Ethiopians

AIDS

Volumn 21, Issue 3, 2007, Pages 369-372

  Tsegaye, Aster ^a   Ran, Leonie ^b   Wolday, Dawit ^a   Petros, Beyene ^c   Nanlohy, Nening M ^b,e   Meles, Hailu ^a   Girma, Mulu ^a   Hailu, Ermias ^a   Borghans, José ^b,e   Miedema, Frank ^b,d,e   Van Baarle, Debbie ^b,e  

^a Ethio Netherlands AIDS Research Project ENARP   (Ethiopia)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

^c ADDIS ABABA UNIVERSITY   (Ethiopia)

^d ACADEMIC MEDICAL CENTER   (Netherlands)

^e UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

GAG PROTEIN; HLA B27 ANTIGEN;

ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CLADISTICS; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DISEASE COURSE; ETHIOPIA; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LONGITUDINAL STUDY; LYMPHOCYTE COUNT; PRIORITY JOURNAL; VIRUS LOAD;

CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; GENE PRODUCTS, GAG; HIV INFECTIONS; HIV-1; HUMANS; LONGITUDINAL STUDIES; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, CYTOTOXIC; VIRAL LOAD;

EID: 33846640138     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/QAD.0b013e32801222e3     Document Type: Article

References (16)

1. Ogg GS, Jin X, Bonhoeffer S, Moss P, Nowak M, Monard S, et al. Decay kinetics of human immunodeficiency virus-specific effector cytotoxic T lymphocytes after combination antiretroviral therapy. J Virol 1999; 73:797-800.
2. Pontesilli O, Klein MR, Kerkhof-Garde SR, Pakker NG, De Wolf F, Schuitemaker H, et al. Longitudinal analysis of human immunodeficiency virus type-1 (HIV-1) specific cytotoxic T lymphocyte responses: a predominant gag-specific response is associated with non-progressive infection. J Infect Dis 1998; 178:1008-1018.
3. Klein MR, Van Baalen CA, Holwerda AM, Kerkhof-Garde SR, Bende RJ, Keet IPM, et al. Kinetics of Gag-specific CTL responses during the clinical course of HIV-1 infection: a longitudinal analysis of rapid progressors and long-term asymptomatics. J Exp Med 1995; 181:1365-1372.
4. Chouquet C, Autran B, Gomard E, Bouley JM, Calvez V, Katlama C, et al. Correlation between breadth of memory HIV-specific cytotoxic T cells, viral load and disease progression in HIV infection. AIDS 2002; 16:2399-2407.
5. Tsegaye A, Wolday D, Otto S, Petros B, Assefa T, Alebachew T, et al. Immunophenotyping of blood lymphocytes at birth, during childhood, and during adulthood in HIV-1-uninfected Ethiopians. Clin Immunol 2003; 109:338-346.
6. Kassu A, Tsegaye A, Petros B, Wolday D, Hailu E, Tilahun T, et al. Distribution of lymphocyte subsets in healthy human immunodeficiency virus-negative adult Ethiopians from two geographic locales. Clin Diagn Lab Immunol 2001; 8:1171-1176.
7. Tsegaye A, Messele T, Tilahun T, Hailu E, Sahlu T, Doorly R, et al. Immunohematological reference ranges for adult Ethiopians. Clin Diagn Lab Immunol 1999; 6:410-414.
8. Mekonnen Y, Geskus RB, Hendriks JC, Messele T, Borghans J, Miedema F, et al. Low CD4 T cell counts before HIV-1 seroconversion do not affect disease progression in Ethiopian factory workers. J Infect Dis 2005; 192:739-748.
9. Mekonnen Y, Sanders E, Messele T, Wolday D, Dorigo-Zestma W, Schaap A, et al. Prevalence and incidence of, and risk factors for, HIV-1 infection among factory workers in Ethiopia, 1997-2001. J Health Popul Nutr 2005; 23:358-368.
10. Sahlu T, Kassa E, Agonafer T, Tsegaye A, Rinke de WT, Gebremariam H, et al. Sexual behaviours, perception of risk of HIV infection, and factors associated with attending HIV post-test counselling in Ethiopia. AIDS 1999; 13:1263-1272.
11. Mashishi T, Gray CM. The ELISPOT assay: an easily transferable method for measuring cellular responses and identifying T cell epitopes. Clin Chem Lab Med 2002; 40:903-910.
12. Betts MR, Krowka JF, Kepler TB, Davidian M, Christopherson C, Kwok S, et al. Human immunodeficiency virus type 1-specific cytotoxic T lymphocyte activity is inversely correlated with HIV type 1 viral load in HIV type 1-infected long-term survivors. AIDS Res Hum Retroviruses 1999; 15:1219-1228.
13. Frahm N, Korber BT, Adams CM, Szinger JJ, Draenert R, Addo MM, et al. Consistent cytotoxic-T-lymphocyte targeting of immunodominant regions in human immunodeficiency virus across multiple ethnicities. J Virol 2004; 78:2187-2200.
14. Goulder PJ, Brander C, Annamalai K, Mngqundaniso N, Govender U, Tang Y, et al. Differential narrow focusing of immunodominant human immunodeficiency virus gag-specific cytotoxic T-lymphocyte responses in infected African and caucasoid adults and children. J Virol 2000; 74:5679-5690.
15. Novitsky V, Rybak N, McLane MF, Gilbert P, Chigwedere P, Klein I, et al. Identification of human immunodeficiency virus type 1 subtype C Gag-, Tat-, Rev-, and Nef-specific elispot-based cytotoxic T-lymphocyte responses for AIDS vaccine design. J Virol 2001; 75:9210-9228.
16. Masemola A, Mashishi T, Khoury G, Mohube P, Mokgotho P, Vardas E, et al. Hierarchical targeting of subtype C human immunodeficiency virus type 1 proteins by CD8+ T cells: correlation with viral load. J Virol 2004; 78:3233-3243.