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Differential scanning calorimetry measurements were made in water. Cooling at a scan rate of 1°C/min produced a transition temperature of 40.2 ± 0.5°C for a sample of para-isomer 6 (2.5 mg/mL) and no detectable transition temperature between 2 and 90°C for meta-isomer 7 under the same conditions.
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Differential scanning calorimetry measurements were made in water. Cooling at a scan rate of 1°C/min produced a transition temperature of 40.2 ± 0.5°C for a sample of para-isomer 6 (2.5 mg/mL) and no detectable transition temperature between 2 and 90°C for meta-isomer 7 under the same conditions.
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The leakage induced by 6 is not due to the sample addition procedure because the other amphiphiles have no effect under the same addition conditions. Furthermore, preincorporation of 6 at 10 μM prior to vesicle formation produces extremely leaky vesicles, which suggests that insertion of 6 into the vesicle membrane is not the process that causes the leakage.
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The leakage induced by 6 is not due to the sample addition procedure because the other amphiphiles have no effect under the same addition conditions. Furthermore, preincorporation of 6 at 10 μM prior to vesicle formation produces extremely leaky vesicles, which suggests that insertion of 6 into the vesicle membrane is not the process that causes the leakage.
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