The efficacy of influenza vaccine for healthy children: A meta-analysis evaluating potential sources of variation in efficacy estimates including study quality

Pediatric Infectious Disease Journal

Volumn 26, Issue 2, 2007, Pages 97-106

  Manzoli, Lamberto ^a   Schioppa, Francesco ^a   Boccia, Antonio ^b   Villari, Paolo ^b  

^a UNIVERSITY OF CHIETI   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Efficacy; Healthy children; Influenza vaccine; Meta analysis; Pediatrics

Indexed keywords

INACTIVATED VIRUS VACCINE; INFLUENZA VACCINE; PLACEBO;

ACUTE OTITIS MEDIA; ARTICLE; CLINICAL TRIAL; CONFIDENCE INTERVAL; DRUG EFFICACY; HUMAN; INFLUENZA; INFLUENZA VACCINATION; LABORATORY DIAGNOSIS; META ANALYSIS; METHODOLOGY; PRIORITY JOURNAL; RANDOMIZATION; RATING SCALE; SYSTEMATIC REVIEW; TREATMENT OUTCOME;

ADOLESCENT; AGE FACTORS; CHILD; CHILD, PRESCHOOL; DOUBLE-BLIND METHOD; HUMANS; INFLUENZA VACCINES; INFLUENZA, HUMAN; OTITIS MEDIA; RANDOMIZED CONTROLLED TRIALS; REGRESSION ANALYSIS; RESEARCH DESIGN;

EID: 33846626370     PISSN: 08913668     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.inf.0000253053.01151.bd     Document Type: Article

References (51)

1. World Health Organization. Influenza vaccines. WHO position paper. Wkly Epidemiol Rec. 2002;77:229-240. Available at: www.who.int/docstore/ wer/pdf/2002/wer7728.pdf. Accessed August 30, 2005.
2. American Academy of Pediatrics Committee on Infectious Diseases. Recommendations for influenza immunization of children. Pediatrics. 2004;113:1441-1447.
3. Harper SA, Fukuda K, Uyeki TM, et al. Centers for Disease Control and Prevention (CDC) Advisory Committee on Immunization Practices (ACIP). Prevention and control of influenza: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. 2004;53:1-40.
4. Nichol KL. The efficacy, effectiveness and cost-effectiveness of inactivated influenza virus vaccines. Vaccine. 2003;21:1769-1775.
5. Halloran EM, Longini IM Jr. Community studies for vaccinating schoolchildren against influenza. Science. 2006;311:615-616.
6. Jefferson T, Smith S, Demicheli V, Harnden A, Rivetti A, Di Pietrantonj C. Assessment of the efficacy and effectiveness of influenza vaccines in healthy children: Systematic review. Lancet. 2005;365:773-780.
7. Negri E, Colombo C, Giordano L, Groth N, Apolone G, La Vecchia C. Influenza vaccine in health children: A meta-analysis. Vaccine. 2005;23:2851-2861.
8. Villari P, Manzoli L, Boccia A. Methodological quality of studies and patient age as major sources of variation in efficacy estimates of influenza vaccination in healthy adults: A meta-analysis. Vaccine. 2004;22:3475-3486.
9. Rudenko LG, Lonskaya NI, Klimov AI, Vasilieva RI, Ramirez A. Clinical and epidemiological evaluation of a live, cold-adapted influenza vaccine for 3-14-year-olds. Bull World Health Organ. 1996;74:77-84.
10. Chalmers TC, Smith H Jr, Blackburn B, et al. A method for assessing the quality of a randomized control trial. Control Clin Trials. 1981;2:31-49.
11. Jadad AR, Moore A, Carroll D, et al. Assessing the quality of reports of randomized clinical trials: Is blinding necessary? Control Clin Trials. 1996;17:1-12.
12. Schulz KF, Chalmers I, Hayes RJ, Altman DG. Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. JAMA. 1995;273:408-412.
13. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7:177-188.
14. Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959;22:719-748.
15. Higgins JPT, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327:557-560.
16. Thompson SG, Sharp SJ. Explaining heterogeneity in meta-analysis. A comparison of methods. Stat Med. 1999;18:2693-2708.
17. Higgins JPT, Thompson SG. Controlling the risk of spurious findings from meta-regression. Stat Med. 2004;23:1663-1682.
18. Sterne JAC, Egger M, Davey Smith G. Investigating and dealing with publication and other biases in meta-analysis. BMJ. 2001;323:101-105.
19. Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315:629-634.
20. Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics. 1994;50:1088-1099.
21. Maynard JE, Dull HB, Hanson ML, Feltz ET, Berger R, Hammes L. Evaluation of monovalent and polyvalent influenza vaccines during an epidemic of type A2 and B influenza. Am J Epidemiol. 1968;87:148-157.
22. Wesselius-de Casparis A, Masurel N, Kerrebijn KF. Field trial with human and equine influenza vaccines in children: Protection and antibody titres. Bull World Health Organ. 1972;46:151-157.
23. Slepushkin AN, Dukova VS, Kalegaeva VA, Kagan AN, Temriuk EE. Results of studying the effectiveness of a live influenza vaccine for peroral use on preschool and schoolchildren. Zh Mikrobiol Epidemiol Immunobiol. 1974;12:24-29.
24. Hoskins TW, Davies JR, Allchin A, Miller CL, Pollock TM. Controlled trial of inactivated influenza vaccine containing the A/Hong Kong strain during an outbreak of influenza due to A/England/42/72 strain. Lancet. 1973;2:116-120.
25. Beutner KR, Chow T, Rubi E, Strussenberg J, Clement J, Ogra PL. Evaluation of a neuraminidase-specific influenza A virus vaccine in children: Antibody responses and effects on two successive outbreaks of natural infection. J Infect Dis. 1979;140:844-850.
26. Feldman S, Wright PF, Webster RG, et al. Use of influenza A virus vaccines in seronegative children: Live cold-adapted versus inactivated whole virus. J Infect Dis. 1985;152:1212-1218.
27. Alexandrova GI, Budilovsky GN, Koval TA, et al. Study of live recombinant cold-adapted influenza bivalent vaccine of type A for use in children: An epidemiological control trial. Vaccine. 1986;4:114-118.
28. Gruber WC, Taber LH, Glezen WP, et al. Live attenuated and inactivated influenza vaccine in school-age children. Am J Dis Child. 1990;144:595-600.
29. Clover RD, Crawford S, Glezen WP, et al. Comparison of heterotypic protection against influenza A/Taiwan/86 (H1N1) by attenuated and inactivated vaccines to A/Chile/83-like viruses. J Infect Dis. 1991;163:300-304.
30. Neuzil KM, Dupont WD, Wright PF, et al. Efficacy of inactivated and cold-adapted vaccines against influenza A infection, 1985 to 1990: The pediatric experience. Pediatr Infect Dis J. 2001;20:733-740.
31. Rudenko LG, Vasil'eva RI, Ismagulov AT, et al. Prophylactic effectiveness of a live recombinant influenza type A vaccine in immunizing children aged 3-14 years. Vopr Virusol. 1996;41:37-39.
32. Piedra PA, Glezen WP. Influenza in children: Epidemiology, immunity, and vaccines. Seminar Pediatr Infect Dis. 1991;2:140-146.
33. Rudenko LG, Slepushkin AN, Monto AS, et al. Efficacy of live attenuated and inactivated influenza vaccines in schoolchildren and their unvaccinated contacts in Novgorod, Russia. J Infect Dis. 1993;168:881-887.
34. Khan AS, Polezhaev F, Vasiljeva R, et al. Comparison of US inactivated split-virus and Russian live attenuated, cold-adapted trivalent influenza vaccines in Russian schoolchildren. J Infect Dis. 1996;173:453-456.
35. Clements DA, Langdon L, Bland CRN, et al. Influenza A vaccine decreases the incidence of otitis media in 6- to 30-month-old children in day care. Arch Pediatr Adolesc Med. 1995;149:1113-1117.
36. Colombo C, Argiolas L, La Vecchia C, et al. Influenza vaccine in healthy preschool children. Rev Epidemiol Sante Publique. 2001;49:157-162.
37. Belshe RB, Mendelman PM, Treanor J, et al. The efficacy of live attenuated, cold-adapted, trivalent, intranasal influenzavirus vaccine in children. N Engl J Med. 1998;338:1405-1412.
38. Belshe RB, Gruber WC, Mendelman PM, et al. Efficacy of vaccination with live attenuated, cold-adapted, trivalent, intranasal influenza virus vaccine against a variant (A/Sidney) not contained in the vaccine. J Pediatr. 2000;136:168-175.
39. Hoberman A, Greenberg DP, Paradise JL, et al. Effectiveness of inactivated influenza vaccine in preventing acute otitis media in young children. JAMA. 2003;290:1608-1616.
40. Grigor'eva EP, Desheva IuA, Donina SA, et al. The comparative characteristics of the safety, immunogenic activity and prophylactic potency of the adult and children types of live influenza vaccine in schoolchildren aged 7-14 years. Vopr Virusol. 2002;47:24-27.
41. Esposito S, Marchisio P, Bosis S, et al. Clinical ed economic impact of influenza vaccination on healthy children aged 2-5 years. Vaccine. 2006;24:629-635.
42. Hurwitz ES, Haber M, Chang A, et al. Studies of the 1996-1997 inactivated influenza vaccine among children attending day care: Immunologic response, protection against infection, and clinical effectiveness. J Infect Dis. 2000;182:1218-1221.
43. Marchisio P, Cavagna R, Maspes B, et al. Efficacy of intranasal virosomal influenza vaccine in the prevention of recurrent acute otitis media in children. Clin Infect Dis. 2002;35:168-174.
44. Schulz KF, Chalmers I, Hayes RJ, Altman DG. Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. JAMA. 1995;273:408-412.
45. Moher D, Jones A, Cook DJ, et al. Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta-analyses? Lancet. 1998;352:609-613.
46. Slepushkin AN, Obrosova-Serova NP, Burtseva EI, et al. Comparison of live attenuated and inactivated influenza vaccines in schoolchildren in Russia. I. Safety and efficacy in two Moscow schools 1987/1988. Vaccine. 1993;11:323-328.
47. Demicheli V, Jefferson TO, Rivetti D, Deeks JJ. Prevention and early treatment of influenza in healthy adults. Vaccine. 2000;18:957-1030.
48. Manzoli L. Influenza vaccine for civilian aircrew: Is it really effective? Aviat Space Environ Med. 2003;74:1211.
49. Egger M, Davey Smith M. Meta-analysis: Bias in location and selection of studies. BMJ. 1998;316:61-66.
50. Zangwill KM, Belshe RB. Safety and efficacy of trivalent inactivated influenza vaccine in young children: A summary of the new era of routine vaccination. Pediatr Infect Dis J. 2004;23:189-200.
51. Shang A, Huwiler-Muntener K, Nartey L, et al. Are the clinical effects of homeopathy placebo effects? Comparative study of placebo-controlled trials of homeopathy and allopathy. Lancet. 2005;366:726-732.