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Volumn 18, Issue 1, 2007, Pages 45-50

Lamotrigine is an open-channel blocker of the nicotinic acetylcholine receptor

Author keywords

Antiepileptic drug; Cholinergic receptor; Single channel

Indexed keywords

LAMOTRIGINE; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR BLOCKING AGENT; VOLTAGE GATED SODIUM CHANNEL;

EID: 33846622317     PISSN: 09594965     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.wnr.0000246323.66438.94     Document Type: Article
Times cited : (18)

References (24)
  • 2
    • 0025856536 scopus 로고
    • Neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes have a pentameric quaternary structure
    • Anand R, Conroy WG, Schoepfer R, Whiting P, Lindstrom J. Neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes have a pentameric quaternary structure. J Biol Chem 1991; 266:11192- 11198.
    • (1991) J Biol Chem , vol.266 , pp. 11192-11198
    • Anand, R.1    Conroy, W.G.2    Schoepfer, R.3    Whiting, P.4    Lindstrom, J.5
  • 3
    • 0029046913 scopus 로고
    • Neuronal nicotinic receptors: Molecular organization and regulations
    • Galzi JL, Changeux JP. Neuronal nicotinic receptors: molecular organization and regulations. Neuropharmacology 1995; 34:563-582.
    • (1995) Neuropharmacology , vol.34 , pp. 563-582
    • Galzi, J.L.1    Changeux, J.P.2
  • 4
    • 11844276603 scopus 로고    scopus 로고
    • Neuronal nicotinic receptors: From structure to pathology
    • Gotti C, Clementi F. Neuronal nicotinic receptors: from structure to pathology. Prog Neurobiol 2004; 74:363-396.
    • (2004) Prog Neurobiol , vol.74 , pp. 363-396
    • Gotti, C.1    Clementi, F.2
  • 5
    • 22844432580 scopus 로고    scopus 로고
    • Neuronal nicotinic acetylcholine receptors: Structural revelations, target identifications, and therapeutic inspirations
    • Jensen AA, Frolund B, Liljefors T, Krogsgaard-Larsen P. Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations. J Med Chem 2005; 48:4705-4745.
    • (2005) J Med Chem , vol.48 , pp. 4705-4745
    • Jensen, A.A.1    Frolund, B.2    Liljefors, T.3    Krogsgaard-Larsen, P.4
  • 6
    • 0030936195 scopus 로고    scopus 로고
    • The acetylcholine receptor ligand-gated channel as a molecular target of disease and therapeutic agents
    • Barrantes FJ. The acetylcholine receptor ligand-gated channel as a molecular target of disease and therapeutic agents. Neurochem Res 1997; 22:391-400.
    • (1997) Neurochem Res , vol.22 , pp. 391-400
    • Barrantes, F.J.1
  • 8
    • 0022900644 scopus 로고
    • Pharmacological studies on lamotrigine, a novel potential antiepileptic drug: II. Neurochemical studies on the mechanism of action
    • Leach MJ, Marden CM, Miller AA. Pharmacological studies on lamotrigine, a novel potential antiepileptic drug: II. Neurochemical studies on the mechanism of action. Epilepsia 1986; 27:490-497.
    • (1986) Epilepsia , vol.27 , pp. 490-497
    • Leach, M.J.1    Marden, C.M.2    Miller, A.A.3
  • 9
    • 0026443902 scopus 로고
    • An in vitro investigation of the action of lamotrigine on neuronal voltage-activated sodium channels
    • Cheung H, Kamp D, Harris E. An in vitro investigation of the action of lamotrigine on neuronal voltage-activated sodium channels. Epilepsy Res 1992; 13:107-112.
    • (1992) Epilepsy Res , vol.13 , pp. 107-112
    • Cheung, H.1    Kamp, D.2    Harris, E.3
  • 10
    • 0027507511 scopus 로고
    • Lamotrigine, phenytoin and carbamazepine interactions on the sodium current present in N4TG1 mouse neuroblastoma cells
    • Lang DG, Wang CM, Cooper BR. Lamotrigine, phenytoin and carbamazepine interactions on the sodium current present in N4TG1 mouse neuroblastoma cells. J Pharmacol Exp Ther 1993; 266:829-835.
    • (1993) J Pharmacol Exp Ther , vol.266 , pp. 829-835
    • Lang, D.G.1    Wang, C.M.2    Cooper, B.R.3
  • 11
    • 0030917687 scopus 로고    scopus 로고
    • Lamotrigine reduces voltage-gated sodium currents in rat central neurons in culture
    • Zona C, Avoli M. Lamotrigine reduces voltage-gated sodium currents in rat central neurons in culture. Epilepsia 1997; 38:522-525.
    • (1997) Epilepsia , vol.38 , pp. 522-525
    • Zona, C.1    Avoli, M.2
  • 12
    • 0032928707 scopus 로고    scopus 로고
    • Cells defective in sphingolipids biosynthesis express low amounts of muscle nicotinic acetylcholine receptor
    • Roccamo AM, Pediconi MF, Aztiria E, Zanello L, Wolstenholme A, Barrantes FJ. Cells defective in sphingolipids biosynthesis express low amounts of muscle nicotinic acetylcholine receptor. Eur J Neurosci 1999; 11:1615-1623.
    • (1999) Eur J Neurosci , vol.11 , pp. 1615-1623
    • Roccamo, A.M.1    Pediconi, M.F.2    Aztiria, E.3    Zanello, L.4    Wolstenholme, A.5    Barrantes, F.J.6
  • 13
    • 0019441262 scopus 로고
    • Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches
    • Hamill OP, Marty A, Neher E, Sakmann B, Sigworth FJ. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch 1981; 391:85-100.
    • (1981) Pflugers Arch , vol.391 , pp. 85-100
    • Hamill, O.P.1    Marty, A.2    Neher, E.3    Sakmann, B.4    Sigworth, F.J.5
  • 14
    • 0035847596 scopus 로고    scopus 로고
    • Steroids differentially inhibit the nicotinic acetylcholine receptor
    • Garbus I, Bouzat C, Barrantes FJ. Steroids differentially inhibit the nicotinic acetylcholine receptor. Neuroreport 2001; 12:227-231.
    • (2001) Neuroreport , vol.12 , pp. 227-231
    • Garbus, I.1    Bouzat, C.2    Barrantes, F.J.3
  • 15
    • 0036629771 scopus 로고    scopus 로고
    • Identification of threonine 422 in transmembrane domain alpha M4 of the nicotinic acetylcholine receptor as a possible site of interaction with hydrocortisone
    • Garbus I, Roccamo AM, Barrantes FJ. Identification of threonine 422 in transmembrane domain alpha M4 of the nicotinic acetylcholine receptor as a possible site of interaction with hydrocortisone. Neuropharmacology 2002; 43:65-73.
    • (2002) Neuropharmacology , vol.43 , pp. 65-73
    • Garbus, I.1    Roccamo, A.M.2    Barrantes, F.J.3
  • 16
    • 0022560205 scopus 로고
    • Acetylcholine receptor activation by a site-selective ligand: Nature of brief open and closed states in BC3H-1 cells
    • Sine SM, Steinbach JH. Acetylcholine receptor activation by a site-selective ligand: nature of brief open and closed states in BC3H-1 cells. J Physiol 1986; 370:357-379.
    • (1986) J Physiol , vol.370 , pp. 357-379
    • Sine, S.M.1    Steinbach, J.H.2
  • 17
    • 0017905087 scopus 로고
    • Local anaesthetics transiently block currents through single acetylcholine-receptor channels
    • Neher E, Steinbach JH. Local anaesthetics transiently block currents through single acetylcholine-receptor channels. J Physiol 1978; 277:153-176.
    • (1978) J Physiol , vol.277 , pp. 153-176
    • Neher, E.1    Steinbach, J.H.2
  • 18
    • 0020646202 scopus 로고
    • The charge carried by single-channel currents of rat cultured muscle cells in the presence of local anaesthetics
    • Neher E. The charge carried by single-channel currents of rat cultured muscle cells in the presence of local anaesthetics. J Physiol 1983; 339:663-678.
    • (1983) J Physiol , vol.339 , pp. 663-678
    • Neher, E.1
  • 19
    • 0019449132 scopus 로고
    • Block of acetylcholine-activated ion channels by an uncharged local anaesthetic
    • Ogden DC, Siegelbaum SA, Colquhoun D. Block of acetylcholine-activated ion channels by an uncharged local anaesthetic. Nature 1981; 289:596-598.
    • (1981) Nature , vol.289 , pp. 596-598
    • Ogden, D.C.1    Siegelbaum, S.A.2    Colquhoun, D.3
  • 20
    • 0017104508 scopus 로고
    • Drug blockade of open end-plate channels
    • Adams PR. Drug blockade of open end-plate channels. J Physiol 1976; 260:531-552.
    • (1976) J Physiol , vol.260 , pp. 531-552
    • Adams, P.R.1
  • 21
    • 0017755172 scopus 로고
    • Voltage jump analysis of procaine action at frog end-plate
    • Adams PR. Voltage jump analysis of procaine action at frog end-plate. J Physiol 1977; 268:291-318.
    • (1977) J Physiol , vol.268 , pp. 291-318
    • Adams, P.R.1
  • 22
    • 0026532751 scopus 로고
    • Effects of isoflurane on acetylcholine receptor channels. Single-channel currents
    • Dilger JP, Brett RS, Lesko LA. Effects of isoflurane on acetylcholine receptor channels. Single-channel currents. Mol Pharmacol 1992; 41:127-133.
    • (1992) Mol Pharmacol , vol.41 , pp. 127-133
    • Dilger, J.P.1    Brett, R.S.2    Lesko, L.A.3
  • 23
    • 0025731038 scopus 로고
    • Actions of n-alcohols on nicotinic acetylcholine receptor channels in cultured rat myotubes
    • Murrell RD, Braun MS, Haydon DA. Actions of n-alcohols on nicotinic acetylcholine receptor channels in cultured rat myotubes. J Physiol 1991; 437:431-448.
    • (1991) J Physiol , vol.437 , pp. 431-448
    • Murrell, R.D.1    Braun, M.S.2    Haydon, D.A.3
  • 24
    • 0028715919 scopus 로고
    • Routine use of lamotrigine, a new antiepileptic medication, and the value of measuring its blood levels
    • Beran RG, Sheehan K, Tilley MI. Routine use of lamotrigine, a new antiepileptic medication, and the value of measuring its blood levels. Clin Exp Neurol 1994; 31:61-67.
    • (1994) Clin Exp Neurol , vol.31 , pp. 61-67
    • Beran, R.G.1    Sheehan, K.2    Tilley, M.I.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.