Identification of Dok-4b, a Dok-4 splice variant with enhanced inhibitory properties

Biochemical and Biophysical Research Communications

Volumn 354, Issue 3, 2007, Pages 783-788

  Baldwin, Cindy ^a,b   Bedirian, Arda ^a   Li, Hongping ^a   Takano, Tomoko ^a   Lemay, Serge ^a,b  

^a MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

Adapter molecules; Dok 4; Elk 1; Epithelial cells; Epithelial growth factor receptor; Erk; Fyn; Ret; Splice variant; Tyrosine kinases

Indexed keywords

DOK 4B PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN; PROTEIN TYROSINE KINASE; TRANSCRIPTION FACTOR ELK 1; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; COW; EMBRYO; ENZYME INHIBITION; EPITHELIUM CELL; FEMALE; GENE SEQUENCE; GENOME; HUMAN; HUMAN CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PHYSICAL CHEMISTRY; PREDICTION; PRIMATE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN VARIANT;

ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CATTLE; CELL LINE; ENZYME ACTIVATION; ENZYME INHIBITORS; EPITHELIAL CELLS; ETS-DOMAIN PROTEIN ELK-1; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; PHOSPHOPROTEINS; PRIMATES; PROTEIN-TYROSINE KINASES; RODENTIA; VARIATION (GENETICS);

PRIMATES; RODENTIA;

EID: 33846615910     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.01.054     Document Type: Article

References (23)

1. Cong F., Yuan B., and Goff S.P. Characterization of a novel member of the DOK family that binds and modulates Abl signaling. Mol. Cell. Biol. 19 (1999) 8314-8325
2. Lemay S., Davidson D., Latour S., and Veillette A. Dok-3, a novel adapter molecule involved in the negative regulation of immunoreceptor signaling. Mol. Cell. Biol. 20 (2000) 2743-2754
3. Nelms K., Snow A.L., Hu-Li J., and Paul W.E. FRIP, a hematopoietic cell-specific rasGAP-interacting protein phosphorylated in response to cytokine stimulation. Immunity 9 (1998) 13-24
4. Grimm J., Sachs M., Britsch S., Di Cesare S., Schwarz-Romond T., Alitalo K., and Birchmeier W. Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation. J. Cell. Biol. 154 (2001) 345-354
5. Bedirian A., Baldwin C., Abe J., Takano T., and Lemay S. Pleckstrin homology and phosphotyrosine-binding domain-dependent membrane association and tyrosine phosphorylation of Dok-4, an inhibitory adapter molecule expressed in epithelial cells. J. Biol. Chem. 279 (2004) 19335-19349
6. Crowder R.J., Enomoto H., Yang M., Johnson Jr. E.M., and Milbrandt J. Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth. J. Biol. Chem. 279 (2004) 42072-42081
7. Okada K., et al. The muscle protein Dok-7 is essential for neuromuscular synaptogenesis. Science 312 (2006) 1802-1805
8. Tamir I., Stolpa J.C., Helgason C.D., Nakamura K., Bruhns P., Daeron M., and Cambier J.C. The RasGAP-binding protein p62dok is a mediator of inhibitory FcgammaRIIB signals in B cells. Immunity 12 (2000) 347-358
9. Yamanashi Y., Tamura T., Kanamori T., Yamane H., Nariuchi H., Yamamoto T., and Baltimore D. Role of the rasGAP-associated docking protein p62(dok) in negative regulation of B cell receptor-mediated signaling. Genes Dev. 14 (2000) 11-16
10. Suzu S., Tanaka-Douzono M., Nomaguchi K., Yamada M., Hayasawa H., Kimura F., and Motoyoshi K. p56(dok-2) as a cytokine-inducible inhibitor of cell proliferation and signal transduction. EMBO J. 19 (2000) 5114-5122
11. Di Cristofano A., Niki M., Zhao M., Karnell F.G., Clarkson B., Pear W.S., Van Aelst L., and Pandolfi P.P. p62(dok), a negative regulator of Ras and mitogen-activated protein kinase (MAPK) activity, opposes leukemogenesis by p210(bcr-abl). J. Exp. Med. 194 (2001) 275-284
12. White M.F., and Yenush L. The IRS-signaling system: a network of docking proteins that mediate insulin and cytokine action. Curr. Top. Microbiol. Immunol. 228 (1998) 179-208
13. Jacobs A.R., LeRoith D., and Taylor S.I. Insulin receptor substrate-1 pleckstrin homology and phosphotyrosine-binding domains are both involved in plasma membrane targeting. J. Biol. Chem. 276 (2001) 40795-40802
14. van Dijk T.B., van Den Akker E., Amelsvoort M.P., Mano H., Lowenberg B., and von Lindern M. Stem cell factor induces phosphatidylinositol 3′-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells. Blood 96 (2000) 3406-3413
15. Zhao M., Schmitz A.A., Qin Y., Di Cristofano A., Pandolfi P.P., and Van Aelst L. Phosphoinositide 3-kinase-dependent membrane recruitment of p62(dok) is essential for its negative effect on mitogen-activated protein (MAP) kinase activation. J. Exp. Med. 194 (2001) 265-274
16. Gerard A., et al. Functional interaction of RasGAP-binding proteins Dok-1 and Dok-2 with the Tec protein tyrosine kinase. Oncogene 23 (2004) 1594-1598
17. Jones N., and Dumont D.J. Recruitment of Dok-R to the EGF receptor through its PTB domain is required for attenuation of Erk MAP kinase activation. Curr. Biol. 9 (1999) 1057-1060
18. Murakami H., Yamamura Y., Shimono Y., Kawai K., Kurokawa K., and Takahashi M. Role of Dok1 in cell signaling mediated by RET tyrosine kinase. J. Biol. Chem. 277 (2002) 32781-32790
19. Shinohara H., Yasuda T., and Yamanashi Y. Dok-1 tyrosine residues at 336 and 340 are essential for the negative regulation of Ras-Erk signalling, but dispensable for rasGAP-binding. Genes Cells 9 (2004) 601-607
20. Cai D., Dhe-Paganon S., Melendez P.A., Lee J., and Shoelson S.E. Two new substrates in insulin signaling, IRS5/DOK4 and IRS6/DOK5. J. Biol. Chem. 278 (2003) 25323-25330
21. Uchida M., et al. Dok-4 regulates GDNF-dependent neurite outgrowth through downstream activation of Rap1 and mitogen-activated protein kinase. J. Cell Sci. 119 (2006) 3067-3077
22. Itoh S., et al. Mitochondrial Dok-4 recruits Src kinase and regulates NF-kappaB activation in endothelial cells. J. Biol. Chem. 280 (2005) 26383-26396
23. Ames B.N., Cathcart R., Schwiers E., and Hochstein P. Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis. Proc. Natl. Acad. Sci. USA 78 (1981) 6858-6862