Antiestrogenic activity of vitamin A in in vivo uterotrophic assay

Life Sciences

Volumn 80, Issue 10, 2007, Pages 945-949

  Koda, Tomoko ^a   Imai, Hideki ^a   Morita, Masatoshi ^b  

^a UNIVERSITY OF MIYAZAKI   (Japan)

^b NATIONAL INSTITUTE FOR ENVIRONMENTAL STUDIES   (Japan)

Author keywords

All trans retinoic acid; Antiestrogenic activity; Retinoic acid receptor; Retinoid X receptor; Uterotrophic assay

Indexed keywords

ESTROGEN RECEPTOR ALPHA; ETHINYLESTRADIOL; MESSENGER RNA; RETINOIC ACID; RETINOIC ACID RECEPTOR BETA; RETINOID X RECEPTOR GAMMA; RETINOL; RETINOL BINDING PROTEIN; RETINOL BINDING PROTEIN I; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; ASSAY; DRUG ACTIVITY; FEMALE; IN VIVO STUDY; NONHUMAN; NUCLEOTIDE SEQUENCE; OVARIECTOMY; RAT; RECEPTOR UPREGULATION; STATISTICAL SIGNIFICANCE; UTEROTROPHIC ASSAY; UTERUS WEIGHT;

ANIMALS; ESTRADIOL CONGENERS; ESTROGEN ANTAGONISTS; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; ETHINYL ESTRADIOL; FEMALE; ORGAN SIZE; OVARIECTOMY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, RETINOIC ACID; RETINOID X RECEPTOR GAMMA; RNA, MESSENGER; TRETINOIN; UP-REGULATION; UTERUS;

RATTUS;

EID: 33846609135     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2006.11.026     Document Type: Article

References (26)

1. Allenby G., Bocquel M.T., Saunders M., Kazmer S., Speck J., Rosenberger M., Lovey A., Kastner P., Grippo J.F., Chambon P., and Levin A.A. Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids. Proceedings of the National Academy of Sciences of the United States of America 90 1 (1993) 30-34
2. Bo W.J., and Smith M.S. The effect of retinol and retinoic acid on the morphology of the rat uterus. The Anatomical Record 156 1 (1966) 5-10
3. Boettger-Tong H.L., and Stancel G.M. Retinoic acid inhibits estrogen-induced uterine stromal and myometrial cell proliferation. Endocrinology 136 7 (1995) 2975-2983
4. Boyle J.O., Langenfeld J., Lonardo F., Sekula D., Reczek P., Rusch V., Dawson M.I., and Dmitrovsky E. Cyclin D1 proteolysis: a retinoid chemoprevention signal in normal, immortalized, and transformed human bronchial epithelial cells. Journal of National Cancer Institute 91 4 (1999) 373-379
5. Demirpence E., Balaguer P., Trousse F., Nicolas J.C., Pons M., and Gagne D. Antiestrogenic effects of all-trans-retinoic acid and 1,25-dihydroxyvitamin D3 in breast cancer cells occur at the estrogen response element level but through different molecular mechanisms. Cancer Research 54 6 (1994) 1458-1464
6. Evans R.M. The steroid and thyroid hormone receptor superfamily. Science 240 4854 (1998) 889-895
7. Fontana J.A., Miranda D., and Mezu A.B. Retinoic acid inhibition of human breast carcinoma proliferation is accompanied by inhibition of the synthesis of a Mr 39,000 protein. Cancer Research 50 7 (1990) 1977-1982
8. Jetten A.M., De Luca L.M., Nelson K., Schroeder W., Burlingame S., and Fujimoto W. Regulation of cornifin α expression in the vaginal and uterine epithelium by estrogen and retinoic acid. Molecular and Cellular Endocrinology 123 1 (1996) 7-15
9. Kanno J., Onyon L., Haseman J., Fenner-Crisp P., Ashby J., and Owens W. The OECD program to validate the rat uterotrophic bioassay to screen compounds for in vivo estrogenic responses: phase 1. Environmental Health Perspectives 109 8 (2001) 785-794
10. Masui F., Matsuda M., Akazome Y., Imaoka T., and Mori T. Prevention of neonatal estrogen imprinting by vitamin A as indicated by estrogen receptor expression in the mouse vagina. Cell and Tissue Research 306 3 (2001) 441-447
11. McCormick AM., and Napoli J.L. Identification of 5,6-epoxyretinoic acid as an endogenous retinol metabolite. The Journal of Biological Chemistry 257 4 (1982) 1730-1735
12. Medlock K.L., Lyttle C.R., Kelepouris N., Newman E.D., and Sheehan D.M. Estradiol down-regulation of the rat uterine estrogen receptor. Proceedings of the Society for Experimental Biology and Medicine 196 3 (1991) 293-300
13. Mohamed M.K., and Abdel-Rahman A.A. Effect of long-term ovariectomy and estrogen replacement on the expression of estrogen receptor gene in female rats. European Journal of Endocrinology 142 3 (2000) 307-314
14. Muller P., Kietz S., Gustafsson J.A., and Strom A. The anti-estrogenic effect of all-trans-retinoic acid on the breast cancer cell line MCF-7 is dependent on HES-1 expression. The Journal of Biological Chemistry 277 32 (2002) 28376-28379
15. Murata T., Narita K., Honda K., Matsukawa S., and Higuchi T. Differential regulation of estrogen receptor alpha and beta mRNAs in the rat uterus during pregnancy and labor: possible involvement of estrogen receptors in oxytocin receptor regulation. Endocrine Journal 50 5 (2003) 579-587
16. Noy N. Retinoid-binding proteins: mediators of retinoid action. The Biochemical Journal 348 3 (2000) 481-495
17. Ponnamperuma R.M., Kirchhof S.M., Trifiletti L., and De Luca L.M. Ovariectomy increases squamous metaplasia of the uterine horns and survival of SENCAR mice fed a vitamin A-deficient diet. The American Journal of Clinical Nutrition 70 4 (1999) 502-508
18. Sporn M.B., and Roberts A.B. Role of retinoids in differentiation and carcinogenesis. Cancer Research 43 7 (1983) 3034-3040
19. Stunnenberg H.G. Mechanisms of transactivation by retinoic acid receptors. BioEssays 15 5 (1993) 309-315
20. Takeyoshi M., Yamasaki K., Sawaki M., Nakai M., Noda S., and Takatsuki M. The efficacy of endocrine disruptor screening tests in detecting anti-estrogenic effects downstream of receptor-ligand interactions. Toxicology Letters 126 2 (2002) 91-98
21. Tannous-Khuri L., Hillemanns P., Rajan N., Wright T.C., and Talmage D.A. Expression of cellular retinol- and cellular retinoic acid-binding proteins in the rat cervical epithelium is regulated by endocrine stimuli during normal squamous metaplasia. American Journal of Pathology 144 1 (1994) 148-159
22. Valcarcel R., Holz H., Jimenez C.G., Barettino D., and Stunnenberg H.G. Retinoid-dependent in vitro transcription mediated by the RXR/RAR heterodimer. Genes and Development 8 24 (1994) 3068-3079
23. Valcarcel R., Meyer M., Meisterernst M., and Stunnenberg H.G. Requirement of cofactors for RXR/RAR-mediated transcriptional activation in vitro. Biochimica et Biophysica Acta 1350 3 (1997) 229-234
24. Vermot J., Fraulob V., Dolle P., and Niederreither K. Expression of enzymes synthesizing (aldehyde dehydrogenase 1 and retinaldehyde dehydrogenase 2) and metabolizing (Cyp26) retinoic acid in the mouse female reproductive system. Endocrinology 141 10 (2000) 3638-3645
25. Zheng W.L., Bucco R.A., Sierra-Rievera E., Osteen K.G., Melner M.H., and Ong D.E. Synthesis of retinoic acid by rat ovarian cells that express cellular retinoic acid-binding protein-II. Biology of Reproduction 60 1 (1999) 110-114
26. Zhou Y., Shughrue P.J., and Dorsa D.M. Estrogen receptor protein is differentially regulated in the preoptic area of the brain and in the uterus during the rat estrous cycle. Neuroendocrinology 61 3 (1995) 276-283