Antithrombin deficiency and its relationship to severe burns

Burns

Volumn 33, Issue 2, 2007, Pages 173-178

  Niedermayr, M ^a   Schramm, W ^a   Kamolz, L ^a   Andel, D ^a   Romer W ^a   Hoerauf, K ^a   Zimpfer, M ^a,b   Andel, H ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b LUDWIG BOLTZMANN INSTITUTE FOR LUNG VASCULAR RESEARCH   (Austria)

Author keywords

Antithrombin; Burns; Deficiency; Inhalation injury; Prognosis; Regression analysis

Indexed keywords

ANTITHROMBIN III;

ADULT; ANTITHROMBIN DEFICIENCY; ARTICLE; BODY SURFACE; BURN; CONTINUOUS INFUSION; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; HOSPITALIZATION; HUMAN; INCIDENCE; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MORTALITY; SUBSTITUTION THERAPY;

ANTICOAGULANTS; ANTITHROMBIN III; ANTITHROMBIN III DEFICIENCY; BURNS; FEMALE; HUMANS; LENGTH OF STAY; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; REGRESSION ANALYSIS; RETROSPECTIVE STUDIES; RISK FACTORS;

EID: 33846599364     PISSN: 03054179     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.burns.2006.06.011     Document Type: Article

References (27)

1. Bayston T.A., and Lane D.A. Antithrombin: molecular basis of deficiency. Thromb Haemost 78 1 (1997) 339-343
2. Quinsey N.S., Greedy A.L., Bottomley S.P., Whisstock J.C., and Pike R.N. Antithrombin: in control of coagulation. Int J Biochem Cell Biol 36 3 (2004) 386-389
3. Kowal-Vern A., Gamelli R.L., Walenga J.M., Hoppensteadt D., Sharp-Pucci M., and Schumacher H.R. The effect of burn wound size on hemostasis: a correlation of the hemostatic changes to the clinical state. J Trauma 33 1 (1992) 50-56 (discussion 56-57)
4. Souter P.J., Thomas S., Hubbard A.R., Poole S., Romisch J., and Gray E. Antithrombin inhibits lipopolysaccharide-induced tissue factor and interleukin-6 production by mononuclear cells, human umbilical vein endothelial cells, and whole blood. Crit Care Med 29 1 (2001) 134-139
5. Senden N.H., Jeunhomme T.M., Heemskerk J.W., Wagenvoord R., van't Veer C., Hemker H.C., et al. Factor Xa induces cytokine production and expression of adhesion molecules by human umbilical vein endothelial cells. J Immunol 161 8 (1998) 4318-4324
6. Minnema M.C., Chang A.C., Jansen P.M., Lubbers Y.T., Pratt B.M., Whittaker B.G., et al. Recombinant human antithrombin III improves survival and attenuates inflammatory responses in baboons lethally challenged with Escherichia coli. Blood 95 4 (2000) 1117-1123
7. Okajima K., and Uchiba M. The anti-inflammatory properties of antithrombin III: new therapeutic implications. Semin Thromb Hemost 24 1 (1998) 27-32
8. Schoots I.G., Levi M., van Vliet A.K., Maas A.M., Roossink E.H., and van Gulik T.M. Inhibition of coagulation and inflammation by activated protein C or antithrombin reduces intestinal ischemia/reperfusion injury in rats. Crit Care Med 32 6 (2004) 1375-1383
9. Uchiba M., and Okajima K. Antithrombin III (AT III) prevents LPS-induced pulmonary vascular injury: novel biological activity of AT III. Semin Thromb Hemost 23 6 (1997) 583-590
10. Opal S.M. Therapeutic rationale for antithrombin III in sepsis. Crit Care Med 28 9 Suppl (2000) S34-S37
11. Baudo F., Caimi T.M., de Cataldo F., Ravizza A., Arlati S., Casella G., et al. Antithrombin III (ATIII) replacement therapy in patients with sepsis and/or postsurgical complications: a controlled double-blind, randomized, multicenter study. Intensive Care Med 24 4 (1998) 336-342
12. Eisele B., Lamy M., Thijs L.G., Keinecke H.O., Schuster H.P., Matthias F.R., et al. Antithrombin III in patients with severe sepsis. A randomized, placebo-controlled, double-blind multicenter trial plus a meta-analysis on all randomized, placebo-controlled, double-blind trials with antithrombin III in severe sepsis. Intensive Care Med 24 7 (1998) 663-672
13. Fourrier F., Chopin C., Huart J.J., Runge I., Caron C., and Goudemand J. Double-blind, placebo-controlled trial of antithrombin III concentrates in septic shock with disseminated intravascular coagulation. Chest 104 3 (1993) 882-888
14. Warren B.L., Eid A., Singer P., Pillay S.S., Carl P., Novak I., et al. Caring for the critically ill patient. High-dose antithrombin III in severe sepsis: a randomized controlled trial. JAMA 286 15 (2001) 1869-1878
15. Konkle B.A., Bauer K.A., Weinstein R., Greist A., Holmes H.E., and Bonfiglio J. Use of recombinant human antithrombin in patients with congenital antithrombin deficiency undergoing surgical procedures. Transfusion 43 3 (2003) 390-394
16. Williams M.R., D'Ambra A.B., Beck J.R., Spanier T.B., Morale D.L., Helman D.N., et al. A randomized trial of antithrombin concentrate for treatment of heparin resistance. Ann Thorac Surg 70 3 (2000) 873-877
17. Fourrier F., Chopin C., Goudemand J., Hendrycx S., Caron C., Rime A., et al. Septic shock, multiple organ failure, and disseminated intravascular coagulation. Compared patterns of antithrombin III, protein C, and protein S deficiencies. Chest 101 3 (1992) 816-823
18. Kowal-Vern A., Walenga J.M., McGill V., and Gamelli R.L. The impact of antithrombin (H) concentrate infusions on pulmonary function in the acute phase of thermal injury. Burns 27 1 (2001) 52-60
19. Andel H., and Kamolz L.P. Scoring in burned patients. our opinion. Burns 29 4 (2003) 297-298
20. Dehne M.G., Sablotzki A., Hoffmann A., Muhling J., Dietrich F.E., and Hempelmann G. Alterations of acute phase reaction and cytokine production in patients following severe burn injury. Burns 28 6 (2002) 535-542
21. Balk R., Emerson T., Fourrier F., Kruse J.A., Mammen E.F., Schuster H.P., et al. Therapeutic use of antithrombin concentrate in sepsis. Semin Thromb Hemost 24 2 (1998) 183-194
22. Mammen E.F. The haematological manifestations of sepsis. J Antimicrob Chemother 41 Suppl A (1998) 17-24
23. Wurtz R., Karajovic M., Dacumos E., Jovanovic B., and Hanumadass M. Nosocomial infections in a burn intensive care unit. Burns 21 3 (1995) 181-184
24. Hoffmann J.N., Muhlbayer D., Jochum M., and Inthorn D. Effect of long-term and high-dose antithrombin supplementation on coagulation and fibrinolysis in patients with severe sepsis. Crit Care Med 32 9 (2004) 1851-1859
25. Wells S., Sissons M., and Hasleton P.S. Quantitation of pulmonary megakaryocytes and fibrin thrombi in patients dying from burns. Histopathology 8 3 (1984) 517-527
26. Kowal-Vern A., McGill V., Walenga J.M., and Gamelli R.L. Antithrombin(H) concentrate infusions are safe and effective in patients with thermal injuries. J Burn Care Rehabil 21 2 (2000) 115-127
27. Barret J.P., and Gomez P.A. Disseminated intravascular coagulation: a rare entity in burn injury. Burns 31 3 (2005) 354-357