A QTL for osteoporosis detected in an F2 population derived from White Leghorn chicken lines divergently selected for bone index

Animal Genetics

Volumn 38, Issue 1, 2007, Pages 45-49

  Dunn, I C ^a   Fleming, R H ^a   McCormack, H A ^a   Morrice, D ^a   Burt, D W ^a   Preisinger, R ^b   Whitehead, C C ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b LOHMANN TIERZUCHT GMBH   (Germany)

Author keywords

Bone; Egg laying; Hen; Osteoporosis; Quantitative trait loci

Indexed keywords

ANIMAL; ANIMAL DISEASE; ARTICLE; BIRD DISEASE; BREEDING; CHICKEN; CROSS BREEDING; GENETICS; OSTEOPOROSIS; QUANTITATIVE TRAIT LOCUS;

ANIMALS; BREEDING; CHICKENS; CROSSES, GENETIC; OSTEOPOROSIS; POULTRY DISEASES; QUANTITATIVE TRAIT LOCI;

EID: 33846593959     PISSN: 02689146     EISSN: 13652052     Source Type: Journal    
DOI: 10.1111/j.1365-2052.2006.01547.x     Document Type: Article

References (18)

1. Bishop S.C., Fleming R.H., McCormack H.A., Flock D.K. & Whitehead C.C. (2000) Inheritance of bone characteristics affecting osteoporosis in laying hens. British Poultry Science 41, 33-40.
2. Budgell K.L. & Silversides F.G. (2004) Bone breakage in three strains of end-of-lay hens. Canadian Journal of Animal Science 84, 745-7.
3. Fleming R.H., McCormack H.A. & Whitehead C.C. (1998) Bone structure and strength at different ages in laying hens and effects of dietary particulate limestone, vitamin K and ascorbic acid. British Poultry Science 39, 434-40.
4. Fleming R.H., McCormack H.A., McTeir L. & Whitehead C.C. (2003) Effects of dietary particulate limestone, vitamin K-3 and fluoride and photostimulation on skeletal morphology and osteoporosis in laying hens. British Poultry Science 44, 683-9.
5. Fleming R.H., McCormack H.A., McTeir L. & Whitehead C.C. (2006) Relationships between genetic, environmental and nutritional factors influencing osteoporosis in laying hens. British Poultry Science 47, 742-755.
6. Gregory N.G. & Wilkins L.J. (1989) Broken bones in domestic-fowl- handling and processing damage in end-of-lay battery hens. British Poultry Science 30, 555-62.
7. Haley C.S., Knott S.A. & Elsen J.M. (1994) Mapping quantitative trait loci in crosses between outbred lines using least-squares. Genetics 136, 1195-207.
8. Jansen R.C. (1993) Interval mapping of multiple quantitative trait loci. Genetics 135, 205-11.
9. Jensen P., Keeling L., Schutz K. et al. (2005) Feather pecking in chickens is genetically related to behavioural and developmental traits. Physiology & Behavior 86, 52-60.
10. X.M., Masinde G., Gu W.K., Wergedal J., Mohan S. & Baylink D.J. (2002) Genetic dissection of femur breaking strength in a large population (MRL/MpJ x SJL/J) of F2 mice: single QTL effects, epistasis, and pleiotropy. Genomics 79, 734-40.
11. Liu Y.Z., Liu Y.J., Recker R.R. & Deng H.W. (2003) Molecular studies of identification of genes for osteoporosis: the 2002 update. Journal of Endocrinology 177, 147-96.
12. Reich A., Jaffe N., Tong A., Lavelin I., Genina O., Pines M., Sklan D., Nussinovitch A. & Monsonego-Ornan E. (2005) Weight loading young chicks inhibits bone elongation and promotes growth plate ossification and vascularization. Journal of Applied Physiology 98, 2381-9.
13. Rennie J.S., Fleming R.H., McCormack H.A., McCorquodale C.C. & Whitehead C.C. (1997) Studies on effects of nutritional factors on bone structure and osteoporosis in laying hens. British Poultry Science 38, 417-24.
14. Schmid M., Nandra I., Guttenbach M. et al. (2000) First report on chicken genes and chromosomes 2000. Cytogenetics and Cell Genetics 90, 169-218.
15. 2 resource population of chickens. Genetics Selection Evolution 37, 677-98.
16. Seaton G., Haley C.S., Knott S.A., Kearsey M. & Visscher P.M. (2002) QTL Express: mapping quantitative trait loci in of simple and complex pedigrees. Bioinformatics 18, 339-40.
17. Whitehead C.C. (2004) Overview of bone biology in the egg-laying hen. Poultry Science 83, 193-99.
18. Whitehead C.C. & Fleming R.H. (2000) Osteoporosis in cage layers. Poultry Science 79, 1033-41.