Propofol modulates Na+-Ca2+ exchange activity via activation of protein kinase C in diabetic cardiomyocytes

Anesthesiology

Volumn 106, Issue 2, 2007, Pages 302-311

  Wickley, Peter J ^a   Shiga, Toshiya ^c   Murray, Paul A ^c   Damron, Derek S ^b  

^a KENT STATE UNIVERSITY   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

2 [2 [4 (4 NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA METHANESULFONATE; BISINDOLYLMALEIMIDE; CALCIUM; FURA 2; PROPOFOL; PROTEIN KINASE C; SODIUM; SODIUM CALCIUM EXCHANGE PROTEIN;

ANESTHESIA MECHANISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CELL ISOLATION; CONTROLLED STUDY; CYTOSOL; DIABETES MELLITUS; DRUG EFFECT; ELECTROSTIMULATION; ENZYME ACTIVATION; ENZYME INHIBITION; HEART MUSCLE CELL; HEART VENTRICLE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SARCOPLASMIC RETICULUM; SODIUM CALCIUM EXCHANGE;

ANIMALS; BLOOD GLUCOSE; CALCIUM; DIABETES MELLITUS, EXPERIMENTAL; ENZYME ACTIVATION; MALE; MYOCYTES, CARDIAC; PROPOFOL; PROTEIN KINASE C; RATS; RATS, SPRAGUE-DAWLEY; SARCOPLASMIC RETICULUM; SODIUM-CALCIUM EXCHANGER; STREPTOZOCIN; THIOUREA;

EID: 33846591844     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/00000542-200702000-00019     Document Type: Article

References (47)

1. 2+ handling in ventricular myocytes isolated from diabetic rats. Am J Physiol 1996; 270:H1529-37
2. 2+ signaling contributes to cardiomyopathy in type 1 diabetic rats. Am J Physiol Heart Circ Physiol 2002; 283:H1398-408
3. 2+ handling in streptozotocin-induced diabetic rat myocardium. Am J Physiol 1999; 277:H2185-94
4. Fein FS, Kornstein LB, Strobeck JE, Capasso JM, Sonnenblick EH: Altered myocardial mechanics in diabetic rats. Circ Res 1980; 47:922-33
5. Lagadic-Gossman D, Feuvray D: Decreased sensitivity of contraction to changes of intracellular pH in papillary muscle from diabetic rat hearts. J Physiol (Lond) 1990; 422:481-97
6. Yu Z, Tibbits GF, McNeill JH: Cellular functions of diabetic cardiomyocytes: Contractility, rapid-cooling contracture, and ryanodine binding. Am J Physiol 1994; 35:H2082-9
7. i responses to isoproterenol and cAMP in isolated cardiomyocytes from experimental diabetic rats. Am J Physiol 1994; 266:H2334-42
8. 2+ transients but not contraction in intact beating guinea pig hearts. Anesth Analg 2000; 90:1286-92
9. Guenoun T, Montagne O, Laplace M, Crozatier B: Propofol-induced modifications of cardiomyocyte calcium transient and sarcoplasmic reticulum function in rats. ANESTHESIOLOGY 2000; 92:542-9
10. Puttick RM, Terrar DA: Effects of propofol and enflurane on action potentials, membrane currents and contraction of guinea-pig isolated ventricular myocytes. Br J Pharmacol 1992; 107:559-65
11. Riou B, Besse S, Lecarpentier Y, Viars P: In vitro effects of propofol on rat myocardium. ANESTHESIOLOGY 1992; 76:609-16
12. van Klarenbosch J, Stienen GJ, de Ruijter W, Scheffer GJ, de Lange JJ: The differential effect of propofol on contractility of isolated myocardial trabeculae of rat and guinea-pig. Br J Pharmacol 2001; 132:742-8
13. de Ruijter W, Stienen GJM, van Klarenbosch J, de Lange JJ: Negative and positive inotropic effects of propofol via L-type calcium channels and the sodium-calcium exchanger in rat cardiac trabeculae. ANESTHESIOLOGY 2002; 97:1146-55
14. Satoh H, Hayashi H, Noda N, Terada H, Kobayashi A, Hirano M, Yamashita Y, Yamazaki N: Regulation of [Na+]i and [Ca2+]i in guinea pig myocytes: Dual loading of fluorescent indicators SBFI and fluo 3. Am J Physiol 2006; 266:H568-76
15. Bers DM, Christensen DM, Nguyen TX: Can Ca entry via Na-Ca exchange directly activate cardiac muscle contraction? J Mol Cell Cardiol 2006; 20:405-14
16. Kanaya N, Gable B, Murray PA, Damron DS: Propofol increases phosphorylation of troponin, I, and myosin light chain 2 via protein kinase C activation in cardiomyocytes. ANESTHESIOLOGY 2003; 98:1363-71
17. + exchange in rat ventricular myocytes. ANESTHESIOLOGY 2001; 94:1096-104
18. 2+ transients and contraction in rat ventricular myocytes at supraclinical concentrations. ANESTHESIOLOGY 1998; 88:781-91
19. 2+, and pH in rat ventricular myocytes. ANESTHESIOLOGY 1998; 89:202-14
20. Satoh H, Ginsburg K, Qing K, Terada H, Hayashi H, Bers DM: KB-R7943 block of Ca2+ influx via Na+/Ca2+ exchange does not alter twitches or glycoside inotropy but prevents Ca2+ overload in rat ventricular myocytes. Circulation 2000; 101:1441-6
21. Bassani JWM, Bassani RA, Bers DM: Relaxation in rabbit and rat cardiac cells: Species-dependent differences in cellular mechanisms. J Physiol 1994; 476:279-93
22. Bassani JWM, Yuan W, Bers DM: Fractional SR Ca release is regulated by trigger Ca and SR Ca content in cardiac myocytes. Am J Physiol 1995; 268:1313-29
23. + overload. J Physiol 2000; 527:85-94
24. 2+ exchanger activity in the diabetic heart. Cardiovasc Res 1997; 34:129-36
25. Doliba NM, Babsky AM, Wehrli SL, Ivanics TM, Friedman MF, Osbakken MD: Metabolic control of sodium transport in streptozotocin-induced diabetic rat hearts. Biochemistry 2000; 65:502-8
26. Golfman L, Dixon IM, Takeda N, Lukas A, Dakshinamurti K, Dhalla NS: Cardiac sarcolemmal Na(+)-Ca2+ exchange and Na(+)-K+ ATPase activities and gene expression in alloxan-induced diabetes in rats. Mol Cell Biochem 2006; 188:91-101
27. 2+ fluxes, and contraction in ventricular myocytes. Circ Res 1990; 66:622-32
28. 2+ channel. Cardiovasc Res 1990; 24:381-9
29. 2+ currents in ventricular myocytes from rats with chronic diabetes. Am J Physiol 1995; 269:H1288-96
30. Yaras N, Ugur M, Ozdemir S, Gurdal H, Purali N, Lacampagne A, Vassort G, Turan B: Effects of diabetes on ryanodine receptor Ca release Channel (RyR2) and Ca2+ homeostasis in rat heart. Diabetes 2005; 54:3082-8
31. Zhong Y, Ahmed S, Grupp IL, Matlib MA, Altered SR: Protein expression associated with contractile dysfunction in diabetic rat hearts. Am J Physiol 2001; 281:H1137-47
32. 2+-cycling proteins may underlie sarcoplasmic reticulum dysfunction in the diabetic heart. Diabetes 2001; 50:2133-8
33. Vasanji Z, Dhalla NS, Netticadan T: Increased inhibition of SERCA2 by phospholamban in the type 1 diabetic heart. Mol Cell Biochem 2004; 261:245-9
34. + exchange in rat ventricular myocytes. ANESTHESIOLOGY 2001; 94:1096-104
35. Aomine M, Yamato T: Electrophysiological properties of ventricular muscle obtained from spontaneously diabetic mice. Exp Anim 2000; 49:23-33
36. 2+ sensitivity via a PKC-, nitric oxide synthase-dependent pathway in diabetic cardiomyocytes. ANESTHESIOLOGY 2005; 104:978-87
37. Watano T, Kimura J: Calcium-dependent inhibition of the sodium-calcium exchange current by KB-R7943. Can J Cardiol 1998; 14:259-62
38. Bers DM, Bassani RA, Bassani JWM, Baudet S, Hryshko LV: Paradoxical twitch potentiation after rest in cardiac muscle: Increased fractional release of SR calcium. J Mol Cell Cardiol 1993; 25:1047-57
39. Bassani JWM, Bassani RA, Bers DM: Twitch-dependent SR Ca accumulation and release in rabbit ventricular myocytes. Am J Physiol 1993; 265:533-40
40. i during caffeine contractures in rabbit cardiac myocytes. J Physiol 1992; 453:591-608
41. Bers DM, Bridge JHB: Relaxation of rabbit ventricular muscle by Na-Ca exchange and sarcoplasmic reticulum Ca-pump: Ryanodine and voltage sensitivity. Circ Res 1989; 65:334-42
42. 2+ uptake but decreases myocyte shortening. Circulation 2004; 110:3553-9
43. Ren J, Davidoff AJ: Diabetes rapidly induces contractile dysfunctions in isolated ventricular myocytes. Am J Physiol 1997; 272:H148-58
44. Kanaya N, Gable B, Wickley PJ, Murray PA, Damron DS: Experimental conditions are important determinants of cardiac inotropic effects of propofol. ANESTHESIOLOGY 2005; 103:1026-34
45. Bers DM: Ca transport during contraction and relaxation in mammalian ventricular muscle. Basic Res Cardiol 1997; 92:1-10
46. Morgan DJ, Campbell GA, Crankshaw DP: Pharmacokinetics of propofol when given by intravenous infusion. Br J Clin Pharmacol 1990; 30:144-8
47. Cockshott ID: Propofol (Diprivan) pharmacokinetics and metabolism: An overview. Postgrad Med J 1985; 61:45-50