Spinal mechanisms of NPY analgesia

Peptides

Volumn 28, Issue 2, 2007, Pages 464-474

  Smith, Peter A ^a   Moran, Timothy D ^b   Abdulla, Fuad ^c   Tumber, Kiranjeet K ^d   Taylor, Bradley K ^d  

^a UNIVERSITY OF ALBERTA   (Canada)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

^c HASHEMITE UNIVERSITY   (Jordan)

^d TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Dorsal horn; Inflammatory pain; Neuropathic pain; Substantia gelatinosa; Synaptic transmission

Indexed keywords

4 AMINOBUTYRIC ACID; 6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; CALCIUM CHANNEL; GLYCINE; MORPHINE; MU OPIATE RECEPTOR; N2 DIPHENYLACETYL N (4 UREIDOMETHYLBENZYL)ARGININAMIDE; NALPHA (DIPHENYLACETYL) N (4 HYDROXYBENZYL) DEXTRO ARGININAMIDE; NEUROPEPTIDE Y; NEUROPEPTIDE Y1 RECEPTOR; NEUROPEPTIDE Y2 RECEPTOR;

4 AMINOBUTYRIC ACID RELEASE; ALLODYNIA; ANALGESIA; ANTINOCICEPTION; CALCIUM CURRENT; CHRONIC PAIN; HYPERALGESIA; HYPOREFLEXIA; NERVE ENDING; NERVE FIBER TRANSECTION; NEUROPATHIC PAIN; NEUROPHYSIOLOGY; NEUROTRANSMITTER RELEASE; NOCICEPTION; NONHUMAN; PAIN; PERIPHERAL NERVE INJURY; PRIORITY JOURNAL; REVIEW; SPINAL CORD DORSAL HORN; SPINAL GANGLION; SUBSTANTIA GELATINOSA; SYSTEMATIC REVIEW;

ANALGESICS; ANIMALS; DISEASE MODELS, ANIMAL; INJECTIONS, SPINAL; NEUROPEPTIDE Y; PAIN;

EID: 33846589412     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2006.09.029     Document Type: Review

References (79)

1. 2+ channel current in rat sensory neurons by a G-protein-independent mechanism. J Neurosci 17 (1997) 8721-8728
2. Abdulla F.A., and Smith P.A. Axotomy reduces the effect of analgesic opioids yet increases the effect of nociceptin on dorsal root ganglion neurons. J Neurosci 18 (1998) 9685-9694
3. Abdulla F.A., and Smith P.A. Nerve injury increases an excitatory action of neuropeptide Y- and Y2-agonists on dorsal root ganglion neurons. Neuroscience 89 (1999) 43-60
4. - conductance in rat dorsal root ganglion neurons. J Auton Nerv Syst 78 (1999) 24-29
5. Allen J.M., Gibson S.J., Adrian T.E., Polak J.M., and Bloom S.R. Neuropeptide Y in human spinal cord. Brain Res 308 (1984) 145-148
6. Arners S., and Megerson B.A. Lack of analgesic effect of opioids on neuropathic and idiopathic forms of pain. Pain 33 (1988) 11-23
7. Bennett G.J., Abdelmoumene M., Hayashi H., and Dubner R. Physiology and morphology of substantia gelatinosa neurons intracellularly stained with horseradish peroxidase. J Comp Neurol 194 (1980) 809-827
8. Benoliel R., Eliav E., and Iadarola M.J. Neuropeptide Y in trigeminal ganglion following chronic constriction injury of the rat infraorbital nerve: is there correlation to somatosensory parameters?. Pain 91 (2001) 111-121
9. Brumovsky P., Hofstetter C., Olson L., Ohning G., Villar M., and Hokfelt T. The neuropeptide tyrosine Y1R is expressed in interneurons and projection neurons in the dorsal horn and area X of the rat spinal cord. Neuroscience 138 (2006) 1361-1376
10. Brumovsky P., Stanic D., Shuster S., Herzog H., Villar M., and Hokfelt T. Neuropeptide Y2 receptor protein is present in peptidergic and nonpeptidergic primary sensory neurons of the mouse. J Comp Neurol 489 (2005) 328-348
11. Brumovsky P.R., Shi T.J., Matsuda H., Kopp J., Villar M.J., and Hokfelt T. NPY Y1 receptors are present in axonal processes of DRG neurons. Exp Neurol 174 (2002) 1-10
12. Costigan M., and Woolf C.J. Pain: molecular mechanisms. J Pain 1 (2000) 35-44
13. Coull J.A., Beggs S., Boudreau D., Boivin D., Tsuda M., Inoue K., et al. BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain. Nature 438 (2005) 1017-1021
14. Coull J.A., Boudreau D., Bachand K., Prescott S.A., Nault F., Sik A., et al. Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain. Nature 424 (2003) 938-942
15. Dougherty K.J., Sawchuk M.A., and Hochman S. Properties of mouse spinal lamina I GABAergic interneurons. J Neurophysiol 94 (2005) 3221-3227
16. Dunlap K., and Fischbach G.D. Neurotransmitters decrease the calcium conductance activated by depolarization of embryonic chick sensory neurones. J Physiol (Lond) 317 (1981) 519-535
17. Gibbs J., Flores C.M., and Hargreaves K.M. Neuropeptide Y inhibits capsaicin-sensitive nociceptors via a Y1-receptor-mediated mechanism. Neuroscience 125 (2004) 703-709
18. Gibson S.J., Polak J.M., Allen J.M., Adrian T.E., Kelly J.S., and Bloom S.R. The distribution and origin of a novel brain peptide, neuropeptide Y, in the spinal cord of several mammals. J Comp Neurol 227 (1984) 78-91
19. Gobel S. Golgi studies of the neurons in layer II of the dorsal horn of the medulla (trigeminal nucleus caudalis). J Comp Neurol 180 (1978) 395-414
20. Gobel S. Golgi studies of the trigeminal neurons in layer I of the dorsal horn of the medulla (trigeminal nucleus caudalis). J Comp Neurol 180 (1978) 375-394
21. Graham B.A., Brichta A.M., and Callister R.J. In vivo responses of mouse superficial dorsal horn neurones to both current injection and peripheral cutaneous stimulation. J Physiol (Lond) 561 (2004) 749-763
22. B agonists. J Physiol 507 (1998) 473-483
23. Grudt T.J., and Perl E.R. Correlations between neuronal morphology and electrophysiological features in the rodent superficial dorsal horn. J Physiol 540 (2002) 189-207
24. Hokfelt T., Zhang X., and Wiesenfeld-Hallin Z. Messenger plasticity in primary sensory neurons following axotomy and its functional implications. Trends Neurosci 17 (1994) 22-30
25. Hori Y., Endo K., and Takahashi T. Presynaptic inhibitory action of enkephalin on excitatory transmission in superficial dorsal horn of rat spinal cord. J Physiol 450 (1992) 673-685
26. Hua X.Y., Boublik J.H., Spicer M.A., Rivier J.E., Brown M.R., and Yaksh T.L. The antinociceptive effects of spinally administered neuropeptide Y in the rat: systematic studies on structure-activity relationship. J Pharmacol Exp Ther 258 (1991) 243-248
27. Iadarola M.J., and Caudle R.M. Good pain, bad pain. Science 278 (1997) 239-240
28. Intondi AB, Dahlgren MN, Taylor BK. Intrathecal neuropeptide Y reduces noxious stimulaus evoked fos expression in the dorsal horn. Soc Neurosci Abstr 2004 [program number 864.10].
29. Jassar B.S., Pennefather P.S., and Smith P.A. Changes in potassium channel activity following axotomy of B-cells in bullfrog sympathetic ganglion. J Physiol (Lond) 479 part 3 (1994) 353-370
30. Jessell T.M., and Iversen L.L. Opiate analgesics inhibit substance P release from rat trigeminal nucleus. Nature 268 (1977) 549-551
31. Ji R.R., Zhang X., Wiesenfeld-Hallin Z., and Hokfelt T. Expression of neuropeptide Y and neuropeptide Y (Y1) receptor mRNA in rat spinal cord and dorsal root ganglia following peripheral tissue inflammation. J Neurosci 14 (1994) 6423-6434
32. Kashiba H., Noguchi K., Ueda Y., and Senba E. Neuropeptide Y and galanin are coexpressed in rat large type A sensory neurons after peripheral transection. Peptides 15 (1994) 411-416
33. Kohno T., Ji R.R., Ito N., Allchorne A.J., Befort K., Karchewski L.A., et al. Peripheral axonal injury results in reduced mu opioid receptor pre- and post-synaptic action in the spinal cord. Pain 117 (2005) 77-87
34. Kuphal K., Pedrazzini T., and Taylor B.K. Increased acute and inflammatory nociception and reduced spinal NPY inhibition of neuropathic nociception in neuropeptide Y (NPY) Y1 receptor knockout mice. Soc Neurosci Abstr (2001) 1895
35. Lu Y., and Perl E.R. A specific inhibitory pathway between substantia gelatinosa neurons receiving direct C-fiber input. J Neurosci 23 (2003) 8752-8758
36. Lu Y., and Perl E.R. Modular organization of excitatory circuits between neurons of the spinal superficial dorsal horn (laminae I and II). J Neurosci 25 (2005) 3900-3907
37. Mahinda T.B., and Taylor B.K. Intrathecal neuropeptide Y inhibits behavioral and cardiovascular responses to noxious inflammatory stimuli in awake rats. Physiol Behav 80 (2004) 703-711
38. Mantyh P.W., Allen C.J., Rogers S., DeMaster E., Ghilardi J.R., Mosconi T., et al. Some sensory neurons express neuropeptide Y receptors: potential paracrine inhibition of primary afferent nociceptors following peripheral nerve injury. J Neurosci 14 (1994) 3958-3968
39. Mark M.A., Colvin L.A., and Duggan A.W. Spontaneous release of immunoreactive neuropeptide Y from the central terminals of large diameter primary afferents of rats with peripheral nerve injury. Neuroscience 83 (1998) 581-589
40. Mark M.A., Jarrott B., Colvin L.A., MacMillan S.J., and Duggan A.W. The release of immunoreactive neuropeptide Y in the spinal cord of the anaesthetized rat and cat. Brain Res 754 (1997) 195-203
41. Martire M., Altobelli D., Maurizi S., Preziosi P., and Fuxe K. K(+)-Evoked [(3)H]-d-aspartate release in rat spinal cord synaptosomes: modulation by neuropeptide Y and calcium channel antagonists. J Neurosci Res 62 (2000) 722-729
42. Millan M.J. The induction of pain: an integrative review. Prog Neurobiol 57 (1999) 1-164
43. Miyakawa A., Furue H., Katafuchi T., Jiang N., Yasaka T., Kato G., et al. Action of neuropeptide Y on nociceptive transmission in substantia gelatinosa of the adult rat spinal dorsal horn. Neuroscience 134 (2005) 595-604
44. Moran T.D., Colmers W.F., and Smith P.A. Opioid-like actions of neuropeptide Y in rat substantia gelatinosa: Y1 suppression of inhibition and Y2 suppression of excitation. J Neurophysiol 92 (2004) 3266-3275
45. Moran T.D., and Smith P.A. Morphine-3-d-glucuronide suppresses inhibitory synaptic transmission in the substantia gelatinosa of adult rats. J Pharmacol Exp Ther 302 (2002) 568-576
46. Naveilhan P., Hassani H., Lucas G., Blakeman K.H., Hao J.X., Xu X.J., et al. Reduced antinociception and plasma extravasation in mice lacking a neuropeptide Y receptor. Nature 409 (2001) 513-517
47. Noguchi K., De Leon M., Nahin R.L., Senba E., and Ruda M.A. Quantification of axotomy-induced alteration of neuropeptide mRNAs in dorsal root ganglion neurons with special reference to neuropeptide Y mRNA and the effects of neonatal capsaicin treatment. J Neurosci Res 35 (1993) 54-66
48. Ossipov M.H., Zhang E.T., Carvajal C., Gardell L., Quirion R., Dumont Y., et al. Selective mediation of nerve injury-induced tactile hypersensitivity by neuropeptide Y. J Neurosci 22 (2002) 9858-9867
49. Prescott S.A., and de Koninck Y. Four cell types with distinctive membrane properties and morphologies in lamina I of the spinal dorsal horn of the adult rat. J Physiol 539 (2002) 817-836
50. Rusin K.I., and Moises H.C. μ-Opioid receptor activation reduces multiple components of high-threshold calcium current in rat sensory neurons. J Neurosci 15 (1995) 4315-4327
51. 2+currents, but spares a sustained current. Neuron 6 (1991) 13-20
52. Shi T.J., Cui J.G., Meyerson B.A., Linderoth B., and Hokfelt T. Regulation of galanin and neuropeptide Y in dorsal root ganglia and dorsal horn in rat mononeuropathic models: possible relation to tactile hypersensitivity. Neuroscience 93 (1999) 741-757
53. 2+ channels in acutely isolated neurons from the rat arcuate nucleus. J Neurophysiol 81 (1999) 1391-1403
54. 2+ channels in rat thalamic neurons. J Physiol 531 (2001) 67-79
55. Taiwo O.B., and Taylor B.K. Antihyperalgesic effects of intrathecal neuropeptide Y during inflammation are mediated by Y1 receptors. Pain 96 (2002) 353-363
56. Taylor B.K. Pathophysiologic mechanisms of neuropathic pain. Curr Pain Headache Rep 5 (2001) 151-161
57. Taylor B.K. NPY analgesia: moving from acute to chronic pain. In: Zukowska Z., and Feuerstein G.Z. (Eds). The NPY family of peptides in immune disorders, inflammation, angiogenesis and cancer (2005), Birkhaüser Verlag, Basel 135-148
58. Taylor B.K., Akana S.F., Peterson M.A., Dallman M.F., and Basbaum A.I. Pituitary-adrenocortical responses to persistent noxious stimuli in the awake rat: endogenous corticosterone does not reduce nociception in the formalin test. Endocrinology 139 (1998) 2407-2413
59. Taylor B.K., Peterson M.A., and Basbaum A.I. Exaggerated cardiovascular and behavioral nociceptive responses to subcutaneous formalin in the spontaneously hypertensive rat. Neurosci Lett 201 (1995) 9-12
60. Thomson A.M., West D.C., and Headley P.M. Membrane characteristics and synaptic responsiveness of superficial dorsal horn neurons in a slice preparation of adult rat spinal cord. Eur J Neurosci 1 (1989) 479-488
61. Todd A.J., Hughes D.I., Polgar E., Nagy G.G., Mackie M., Ottersen O.P., et al. The expression of vesicular glutamate transporters VGLUT1 and VGLUT2 in neurochemically defined axonal populations in the rat spinal cord with emphasis on the dorsal horn. Eur J Neurosci 17 (2003) 13-27
62. Todd A.J., and Spike R.C. The localization of classical transmitters and neuropeptides within neurons in laminae I-III of the mammalian spinal dorsal horn. Prog Neurobiol 41 (1993) 609-645
63. Todd A.J., Watt C., Spike R.C., and Sieghart W. Colocalization of GABA, glycine, and their receptors at synapses in the rat spinal cord. J Neurosci 16 (1996) 974-982
64. Wakisaka S., Kajander K.C., and Bennett G.J. Increased neuropeptide Y (NPY)-like immunoreactivity in rat sensory neurons following peripheral axotomy. Neurosci Lett 124 (1991) 200-203
65. Wakisaka S., Kajander K.C., and Bennett G.J. Effects of peripheral nerve injuries and tissue inflammation on the levels of neuropeptide-Y like immunoreactivity in rat primary afferent neurons. Brain Res 598 (1992) 349-352
66. Wakisaka S., Takikita S., Sasaki Y., Kato J., Tabata M.J., and Kurisu K. Cell size-specific appearance of neuropeptide Y in the trigeminal ganglion following peripheral axotomy of different branches of the mandibular nerve of the rat. Brain Res 620 (1993) 347-350
67. Wall P.D., and Pribram K.H. Trigeminal neurotomy and blood pressure responses from stimulation of lateral cerebral cortex of Macaca mulatta. J Neurophysiol 13 (1950) 409-412
68. Williams J.T., North R.A., and Tokimasa T. Inward rectification of resting and opiate-activated potassium currents in rat locus coeruleus neurons. J Neurosci 8 (1988) 4299-4306
69. 2+ channels in rat dorsal root ganglion neurons. J Neurophysiol 73 (1995) 1793-1798
70. Xu I.S., Hao J.X., Xu X.J., Hokfelt T., and Wiesenfeld-Hallin Z. The effect of intrathecal selective agonists of Y1 and Y2 neuropeptide Y receptors on the flexor reflex in normal and axotomized rats. Brain Res 833 (1999) 251-257
71. Xu I.S., Luo L., Ji R.R., Hokfelt T., Xu X.J., and Wiesenfeld-Hallin Z. The effect of intrathecal neuropeptide Y on the flexor reflex in rats after carrageenan-induced inflammation. Neuropeptides 32 (1998) 447-452
72. Zhang X., Bao L., Xu Z.Q., Kopp J., Arvidsson U., Elde R., et al. Localization of neuropeptide Y Y1 receptors in the rat nervous system with special reference to somatic receptors on small dorsal root ganglion neurons. Proc Natl Acad Sci USA 91 (1994) 11738-11742
73. Zhang X., Bean A.J., Wiesenfeld-Hallin Z., and Hokfelt T. Ultrastructural studies on peptides in the dorsal horn of the rat spinal cord. IV. Effects of peripheral axotomy with special reference to neuropeptide Y and vasoactive intestinal polypeptide/peptide histidine isoleucine. Neuroscience 64 (1995) 917-941
74. Zhang X., Shi T., Holmberg K., Landry M., Huang W., Xiao H., et al. Expression and regulation of the neuropeptide Y Y2 receptor in sensory and autonomic ganglia. Proc Natl Acad Sci USA 94 (1997) 729-734
75. Zhang X., Tong Y.G., Bao L., and Hokfelt T. The neuropeptide Y Y1 receptor is a somatic receptor on dorsal root ganglion neurons and a postsynaptic receptor on somatostatin dorsal horn neurons. Eur J Neurosci 11 (1999) 2211-2225
76. Zhang X., Wiesenfeld-Hallin Z., and Hokfelt T. Effect of peripheral axotomy on expression of neuropeptide Y receptor mRNA in rat lumbar dorsal root ganglia. Eur J Neurosci 6 (1994) 43-57
77. Zhang X., Xu Z.Q., Bao L., Dagerlind A., and Hokfelt T. Complementary distribution of receptors for neurotensin and NPY in small neurons in rat lumbar DRGs and regulation of the receptors and peptides after peripheral axotomy. J Neurosci 15 (1995) 2733-2747
78. Zidichouski J.A., Chen H., and Smith P.A. Neuropeptide Y activates inwardly-rectifying K(+)-channels in C-cells of amphibian sympathetic ganglia. Neurosci Lett 117 (1990) 123-128
79. Zucker R.S. Short-term synaptic plasticity. Ann Rev Neurosci 12 (1989) 13-31