Discovery of (Z)-2-phenyl-3-(1H-pyrrol-2-yl)acrylonitrile derivatives active against Haemonchus contortus and Ctenocephalides felis (cat flea)

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 4, 2007, Pages 993-997

  Ali, Abdelselam ^a   Bliese, Marianne ^a   Rasmussen, Jo Anne M ^a   Sargent, Roger M ^b   Saubern, Simon ^a   Sawutz, David G ^c   Wilkie, John S ^a   Winkler, David A ^a   Winzenberg, Kevin N ^a   Woodgate, Ruth C J ^a  

^a CSIRO   (Australia)

^b Schering Plough Pty Ltd   (Australia)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

(Z) 2 phenyl 3 (1H pyrrol 2 yl)acrylonitrile; Ctenocephalides felis (cat flea); Haemonchus contortus; Parasiticide

Indexed keywords

(4,5 DICHLORO 1H PYRROL 2 YL)METHYLENEMALONONITRILE; 2 PHENYL 3 (1H PYRROL 2 YL)ACRYLONITRILE; 2 PHENYL 3 (1H PYRROL 2 YL)ACRYLONITRILE DERIVATIVE; ACRYLONITRILE; CLOSANTEL; FIPRONIL; IVERMECTIN; LEVAMISOLE; UNCLASSIFIED DRUG;

ARTICLE; CTENOCEPHALIDES; DRUG ACTIVITY; DRUG STRUCTURE; HAEMONCHUS CONTORTUS; HIGH THROUGHPUT SCREENING; STRUCTURE ACTIVITY RELATION;

ACRYLONITRILE; ANIMALS; ANTINEMATODAL AGENTS; ANTIPARASITIC AGENTS; CATS; FLEAS; HAEMONCHUS; INSECTICIDES; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; STRUCTURE-ACTIVITY RELATIONSHIP;

CTENOCEPHALIDES FELIS; HAEMONCHUS CONTORTUS;

EID: 33846587404     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.11.043     Document Type: Article

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5. Ctenocephalides felis assays were conducted by the Centre for Entomological Research and Insecticide Technology, UNSW, Randwick, NSW, Australia.
6. 2. Flasks were left to dry for 24 h before flea exposure. Controls were prepared in the same manner, except that no test compound was dissolved in the acetone. Fifteen adult fleas, aged between 3 and 7 days postemergence, were then introduced into each flask. The top of the flasks was covered in Parafilm™ and small holes were made to allow gas exchange. The treatment flasks were held at 25 ± 1 °C and 75 ± 5% humidity for 24 h. Dead fleas in each flask were counted and the pooled data were converted to percentages.
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