Combination of oral antidiabetic agents with basal insulin versus premixed insulin alone in randomized elderly patients with type 2 diabetes mellitus

Journal of the American Geriatrics Society

Volumn 55, Issue 2, 2007, Pages 182-188

  Janka, Hans U ^a   Plewe, Gerd ^a   Busch, Klaus ^b  

^a Klinikum Bremen Nord   (Germany)

^b Diabetologische Schwerpunktpraxis   (Germany)

Author keywords

Insulin glargine; Premixed insulin; Type 2 diabetes mellitus

Indexed keywords

ANTIDIABETIC AGENT; GLIMEPIRIDE; INSULIN; INSULIN GLARGINE; ISOPHANE INSULIN; METFORMIN; NEUTRAL INSULIN;

AGED; ALGORITHM; ARTICLE; CLINICAL TRIAL; COMBINATION CHEMOTHERAPY; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIABETIC NEUROPATHY; DOSE RESPONSE; DRUG DOSE TITRATION; FEMALE; GASTROINTESTINAL DISEASE; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HEMOGLOBIN BLOOD LEVEL; HUMAN; HYPOGLYCEMIA; INSULIN TREATMENT; ISCHIALGIA; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; MULTICENTER STUDY; NEUROLOGIC DISEASE; NON INSULIN DEPENDENT DIABETES MELLITUS; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY TRACT DISEASE;

ADMINISTRATION, ORAL; AGED; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; DRUG THERAPY, COMBINATION; FEMALE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; HYPOGLYCEMIA; HYPOGLYCEMIC AGENTS; INSULIN; MALE; METFORMIN; SULFONYLUREA COMPOUNDS; WEIGHT GAIN;

EID: 33846580098     PISSN: 00028614     EISSN: 15325415     Source Type: Journal    
DOI: 10.1111/j.1532-5415.2007.01043.x     Document Type: Article

References (20)

1. UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 1998;352:837-853.
2. Ohkubo Y, Kishikawa H, Araki E et al. Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: A randomized prospective 6-year study. Diabetes Res Clin Pract 1995;28:103-117.
3. The Diabetes Control and Complications Trial. The absence of a glycemic threshold for the development of long-term complications: The perspective of the Diabetes Control and Complications Trial. Diabetes 1996;45:1289-1298.
4. Stratton I, Adler A, Neil A et al. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): Prospective observational study. BMJ 2000;321:405-412.
5. European Diabetes Policy Group. A desktop guide to Type 2 diabetes mellitus. European Diabetes Policy Group 1999. Diabetic Med 1999;16:716-730.
6. American Diabetes Association. Clinical practice recommendations 2002. Diabetes Care 2002;25(Suppl 1):S1-S147.
7. Gossain VV, Carella MJ, Rovner DR. Management of diabetes in the elderly: A clinical perspective. J Assoc Acad Minor Phys 1994;5:22-31.
8. Rosenstock J. Management of type 2 diabetes mellitus in the elderly: Special considerations. Drugs Aging 2001;18:31-44.
9. Shahar D, Fraser D, Shai I et al. Development of a food frequency questionnaire (FFQ) for an elderly population based on a population survey. J Nutr 2003;133:3625-3629.
10. Belmin J, Valensi P. Novel drug delivery systems for insulin: Clinical potential for use in the elderly. Drugs Aging 2003;20:303-312.
11. Janka HU, Plewe G, Riddle MC et al. Comparison of basal insulin added to oral agents versus twice-daily premixed insulin as initial insulin therapy for type 2 diabetes. Diabetes Care 2005;28:254-259.
12. Korytkowski M. When oral agents fail: Practical barriers to starting insulin. Int J Obes Relat Metab Disord 2002;26:S18-S24.
13. Johnson R, Hauber B, Bolinder B. Trade-offs between glucose control and hypoglycemia in different patient types: Results of a 5-country physician survey (Abstract). Diabetes 2003;52:A264.
14. Fritsche A, Haring HU, Togl E et al. Treat-to-target with add-on basal insulin - can glargine reduce barrier to target attainment (Abstract). Diabetes 2003;52:A119.
15. Singh I, Marshall MC Jr. Diabetes mellitus in the elderly. Endocrinol Metab Clin North Am 1995;24:255-272.
16. Cefalu WT. Evaluation of alternative strategies for optimizing glycemia: progress to date. Am J Med 2002;113(Suppl 6A):23S-35S.
17. Herz M, Sun B, Milicevic Z et al. Comparative efficacy of preprandial or postprandial Humalog Mix75/25 versus glyburide in patients 60-80 years of age with type 2 diabetes mellitus. Clin Ther 2002;24:73-86.
18. Dills D, Schneider J. Clinical evaluation of glimepiride versus glyburide in NIDDM in a double-blind comparative study. Glimepiride/Glyburide Research Group. Horm Metab Res 1996;28:426-429.
19. Kilo C, Mezitis N, Jain R et al. Starting patients with type 2 diabetes on insulin therapy using once-daily injections of biphasic insulin aspart 70/30, biphasic human insulin 70/30, or NPH insulin in combination with metformin. J Diabetes Complications 2003;17:307-313.
20. Raskin P, Allen E, Hollander P et al. Initiating insulin therapy in type 2 diabetes: A comparison of biphasic and basal insulin analogs. Diabetes Care 2005;28:260-265.