Testosterone replacement increases vasodilatory reserve in androgen-deficient female rats

Fertility and Sterility

Volumn 87, Issue 2, 2007, Pages 422-425

  Cooper, Brian C ^a   Gokina, Natalia I ^a   Osol, George ^a  

^a UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN; NITRIC OXIDE; TESTOSTERONE;

ANDROGEN DEFICIENCY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VESSEL REACTIVITY; BLOOD VESSEL TONE; CORONARY ARTERY PRESSURE; ENDOTHELIUM; FEMALE; HORMONE SUBSTITUTION; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE CONTRACTION; VASODILATATION;

ANDROGENS; ANIMALS; BLOOD PRESSURE; CORONARY VESSELS; FEMALE; HORMONE REPLACEMENT THERAPY; MUSCLE, SMOOTH, VASCULAR; OVARIECTOMY; RATS; RATS, SPRAGUE-DAWLEY; TESTOSTERONE; VASODILATION;

EID: 33846576950     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2006.06.033     Document Type: Article

References (20)

1. Braunstein G.D., Sundwall D.A., Katz M., Shifren J.L., Buster J.E., Simon J.A., et al. Safety and efficacy of a testosterone patch for the treatment of hypoactive sexual desire disorder in surgically menopausal women: a randomized, placebo-controlled trial. Arch Intern Med 165 (2005) 1582-1589
2. Buster J.E., Kingsberg S.A., Aguirre O., Brown C., Breaux J.G., Buch A., et al. Testosterone patch for low sexual desire in surgically menopausal women: a randomized trial. Obstet Gynecol 105 (2005) 944-952
3. Shifren J.L., Braunstein G.D., Simon J.A., Casson P.R., Buster J.E., Redmond G.P., et al. Transdermal testosterone treatment in women with impaired sexual function after oophorectomy. N Engl J Med 343 (2000) 682-688
4. Davis S.R., McCloud P., Strauss B.J.G., and Burger H. Testosterone enhances estradiol's effects on postmenopausal bone density and sexuality. Maturitas 21 (1995) 227-236
5. Sherwin B.B. Affective changes with estrogen and androgen replacement therapy in surgically menopausal women. J Affect Disord 14 (1988) 177-187
6. Lobo R.A., Rosen R.C., Yang H.-M., Block B., and Van Der Hoop R.G. Comparative effects of oral esterified estrogens with and without methyltestosterone on endocrine profiles and dimensions of sexual function in postmenopausal women with hypoactive sexual desire. Fertil Steril 79 (2003) 1341-1352
7. Davignon J., and Ganz P. Role of endothelial dysfunction in atherosclerosis. Circulation 109 (2004) 27-32
8. Zeiher A.M., Drexler H., Wollschlager H., and Just H. Modulation of coronary vasomotor tone in humans: progressive endothelial dysfunction with different early stages of coronary atherosclerosis. Circulation 83 (1991) 391-401
9. + channels. Circ Res 79 (1996) 1024-1030
10. Rabii J., and Ganong W.F. Responses of plasma "estradiol" and plasma LH to ovariectomy, ovariectomy plus adrenalectomy, and estrogen injection at various ages. Neuroendocrinology 20 (1976) 270-281
11. 2+ influx in cerebral arteries. Am J Physiol Heart Circ Physiol 282 (2002) H1410-H1420
12. Yi F.X., Zhang A.Y., Campbell W.B., Zou A.P., Van Breemen C., and Li P.L. Simultaneous in situ monitoring of intracellular Ca2+ and NO in endothelium of coronary arteries. Am J Physiol Heart Circ Physiol 283 (2002) H2725-H2732
13. Nathan L., Shi W., Dinh H., Mukherjee T.K., Wang X., Lusis A.J., et al. Testosterone inhibits early atherogenesis by conversion to estradiol: critical role of aromatase. Proc Natl Acad Sci USA 98 (2001) 3589-3593
14. Osol G., Brekke J.F., McElroy-Yaggy K., and Gokina N.I. Myogenic tone, reactivity, and forced dilatation: a three-phase model of in vitro arterial myogenic behavior. Am J Physiol Heart Circ Physiol 283 (2002) H2260-H2267
15. Hughes C.L., Wall L.L., and Creasman W.T. Reproductive hormone levels in gynecologic oncology patients undergoing surgical castration after spontaneous menopause. Gynecol Oncol 40 (1991) 42-45
16. Laughlin G.A., Barrett-Connor E., Kritz-Silverstein D., and von Muhlen D. Hysterectomy, oophorectomy, and endogenous sex hormone levels in older women: the Rancho Bernardo Study. J Clin Endocrinol Metab 85 (2000) 645-651
17. Lea C.K., Moxham V., Reed M.J., and Flanagan A.M. Androstenedione treatment reduces loss of cancellous bone volume in ovariectomised rats in a dose-responsive manner and the effect is not mediated by oestrogen. J Endocrinol 156 (1998) 331-339
18. Parker W.H., Broder M.S., Liu Z., Shoupe D., Farquhar C., and Berek J.S. Ovarian conservation at the time of hysterectomy for benign disease. Obstet Gynecol 106 (2005) 219-226
19. Dixon M.E., Casson P.R., Scarano D., Stanczyk F., and Toth M.J. In postmenopausal women, serum androgen levels correlate with beneficial metabolic and morphometric changes. [abstract]. J Soc Gynecol Investig 13 (2006) 342A
20. Modesti P.A., Olivo G., Pestelli F., Rocchi F., Vanni S., Tedeschini R.C., et al. Peripheral vascular resistance limits exercise functional capacity of mild hypertensives. Angiology 50 (1999) 473-478