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The high basicity of the unprotected oligomer might also buffer the trifluoroacetic acid and, therefore, prevent the cleavage. P. Sieber, Tetrahedron Lett. 1987, 28, 2107-2110.
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The high basicity of the unprotected oligomer might also buffer the trifluoroacetic acid and, therefore, prevent the cleavage. P. Sieber, Tetrahedron Lett. 1987, 28, 2107-2110.
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Please take care to monitor the temperature with a contact thermometer, since the product tends to decarboxylate explosively above 160°C: J. Plöchl, Ber. Dtsch. Chem. Ges. 1886, 19, 6-11.
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Please take care to monitor the temperature with a contact thermometer, since the product tends to decarboxylate explosively above 160°C: J. Plöchl, Ber. Dtsch. Chem. Ges. 1886, 19, 6-11.
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H,H coupling constant for the endo product would be expected to be 10 Hz, A. Josephs, G. Prakash, D. E. Falvey, J. Am. Chem. Soc. 2000, 122, 11219-11225.
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