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ChemBioChem

Volumn 6, Issue 12, 2005, Pages 2255-2260

Design, synthesis and analysis of inhibitors of bacterial aspartate semialdehyde dehydrogenase

(3) Cox, Russell J a Gibson, Jennifer S a Hadfield, Andrea T b

a UNIVERSITY OF BRISTOL (United Kingdom)

b SCHOOL OF MEDICAL SCIENCES (United Kingdom)

Author keywords

Enzymes; Inhibitors; Phosphonates; Simulated docking; Synthesis design

Indexed keywords

ALKENE DERIVATIVE; ASPARTATE SEMIALDEHYDE DEHYDROGENASE INHIBITOR; ASPARTYL BETA PHOSPHATE DERIVATIVE; ENZYME INHIBITOR; MONOFLUOROMETHYLENE PHOSPHONATE; UNCLASSIFIED DRUG; ARGININE; ASPARTATE SEMIALDEHYDE DEHYDROGENASE; ASPARTIC ACID; BACTERIAL PROTEIN; BETA ASPARTYL PHOSPHATE; BETA-ASPARTYL PHOSPHATE; DRUG DERIVATIVE;

ARTICLE; COVALENT BOND; DRUG BINDING; DRUG DESIGN; DRUG MECHANISM; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME SUBSTRATE; FLUORINATION; PRIORITY JOURNAL; SIMULATION; BINDING COMPETITION; BINDING SITE; DRUG ANTAGONISM; ENZYME SPECIFICITY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

BACTERIA (MICROORGANISMS);

ARGININE; ASPARTATE-SEMIALDEHYDE DEHYDROGENASE; ASPARTIC ACID; BACTERIAL PROTEINS; BINDING SITES; BINDING, COMPETITIVE; DRUG DESIGN; ENZYME INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 33846571051 PISSN: 14394227 EISSN: 14397633 Source Type: Journal
DOI: 10.1002/cbic.200500172 Document Type: Article

Times cited : (27)

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