Clonazepam quantification in human plasma by high-performance liquid chromatography coupled with electrospray tandem mass spectrometry in a bioequivalence study

Journal of Mass Spectrometry

Volumn 42, Issue 1, 2007, Pages 81-88

  Cavedal, Luiz E ^a   Mendes, Fabiana D ^a,c   Domingues, Claudia C ^a,b   Patni, Anil K ^d   Monif, Tausif ^d   Reyar, Simrit ^d   Pereira, Alberto Dos S ^c   Mendes, Gustavo D ^a,b,c   De Nucci, Gilberto ^a,b,c,e  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c Galeno Research Unit   (Brazil)

^d RANBAXY LABORATORIES LTD   (India)

^e NONE   (Brazil)

Author keywords

Clonazepam; Healthy volunteer; HPLC MS MS; Pharmacokinetic; Plasma

Indexed keywords

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PHARMACOKINETICS; PLASMAS; STANDARDS;

CLONAZEPAM; HEALTHY VOLUNTEER;

DRUG PRODUCTS;

CLONAZEPAM; DIAZEPAM; ETHER; HEXANE;

ARTICLE; BIOEQUIVALENCE; DRUG BLOOD LEVEL; DRUG DOSAGE FORM COMPARISON; DRUG FORMULATION; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; LIQUID LIQUID EXTRACTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; STANDARD; TABLET;

ADOLESCENT; ADULT; ANTICONVULSANTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLONAZEPAM; CROSS-OVER STUDIES; DIOXANES; HEXANES; HUMANS; MIDDLE AGED; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY; THERAPEUTIC EQUIVALENCY;

EID: 33846562381     PISSN: 10765174     EISSN: 10969888     Source Type: Journal    
DOI: 10.1002/jms.1141     Document Type: Article

References (15)

1. Andre M, Boutroy MJ, Dubruc C, Thenot JP, Bianchetti G, Sola L, Vert P, Morselli PL. Clonazepam pharmacokinetics and therapeutic efficacy in neonatal seizures. Eur. J. Clin. Pharmacol. 1986; 30: 585.
2. Chauhan BL, Sane SP, Revankar SN, Rammamurthy L, Doshi B, Bhatt AD, Bhate VR, Kulkarni RD. Comparative bioavailability study of clonazepam after oral administration of two tablet formulations. J. Assoc. Physicians. India 2000; 48: 985.
3. Crevoisier C, Delisle MC, Joseph I, Foletti G. Comparative single-dose pharmacokinetics of clonazepam following intravenous, intramuscular and oral administration to healthy volunteers. Eur. Neurol. 2003; 49: 173.
4. Song D, Zhang S, Kohlhof K. Quantitative determination of clonazepam in plasma by gas chromatography-negative ion chemical ionization mass spectrometry. J. Chromatogr. B, Biomed. Appl. 1996; 686: 199.
5. Badcock NR, Pollard AC. Micro-determination of clonazepam in plasma or serum by electron-capture gas-liquid chromatography. J. Chromatogr. 1982; 230: 353.
6. Negrusz A, Bowen AM, Moore CM, Dowd SM, Strong MJ, Janicak PG. Deposition of 7-aminoclonazepam and clonazepam in hair following a single dose of Klonopin. J. Anal. Toxicol. 2002; 26: 471.
7. Salem AA, Barsoum BN, Izake EL. Spectrophotometric and fluorimetric determination of diazepam, bromazepam and clonazepam in pharmaceutical and urine samples. Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 2004; 60: 771.
8. Maslanka A, Krzek J. Densitometric high performance thin-layer chromatography identification and quantitative analysis of psychotropic drugs. J. AOAC Int. 2005; 88: 70.
9. Bares IF, Pehourcq F, Jarry C. Development of a rapid RP-HPLC method for the determination of clonazepam in human plasma. J. Pharm. Biomed. Anal. 2004; 36: 865.
10. Nakamura M, Fukawa K, Sugiyama T, Katagiri Y. High-performance liquid chromatographic assay of clonazepam in human plasma using a non-porous silica column. Biol. Pharm. Bull. 2004; 27: 893.
11. Kronstrand R, Nystrom I, Josefsson M, Hodgins S. Segmental ion spray LC-MS-MS analysis of benzodiazepines in hair of psychiatric patients. J. Anal. Toxicol. 2002; 26: 479.
12. Cheze M, Villain M, Pepin G. Determination of bromazepam, clonazepam and metabolites after a single intake in urine and hair by LC-MS/MS. Application to forensic cases of drug facilitated crimes. Forensic. Sci. Int. 2004; 145: 123.
13. Irving RC, Dickson SJ. The detection of sedatives in hair and nail samples using tandem LC-MS-MS. Forensic. Sci. Int. 2006 (in press).
14. Food and Drug Administration. In vivo bioequivalence guidances. Pharmacopeia 1993; 19: 6501.
15. Food and Drug Administration. Bioavailability and bioequivalence requirements; abbreviated applications; proposed revisions-FDA. Proposed rule. Fed. Regist. 1998; 63: 64 222.