The thermodynamic dissociation constants of the anticancer drugs camptothecine, 7-ethyl-10-hydroxycamptothecine, 10-hydroxycamptothecine and 7-ethylcamptothecine by the least-squares nonlinear regression of multiwavelength spectrophotometric pH-titration data

Analytica Chimica Acta

Volumn 584, Issue 2, 2007, Pages 419-432

  Meloun, Milan ^a   Bordovská, Sylva ^a   Vrána, Aleš ^b  

^a UNIVERSITY OF PARDUBICE   (Czech Republic)

^b TEVA PHARMACEUTICALS   (Israel)

Author keywords

10 Hydroxycamptothecine and 7 Ethylcamptothecine; 7 Ethyl 10 hydroxycamptothecine; Anticancer drug; Camptothecine; Dissociation constant; INDICES; MARVIN; PALLAS; Protonation; SPECFIT; Spectrophotometric titration; SQUAD

Indexed keywords

7-ETHYL-10-HYDROXYCAMPTOTHECINE; ANTICANCER DRUG; CAMPTOTHECINE; DISSOCIATION CONSTANT; PROTONATION; SPECTROPHOTOMETRIC TITRATION;

DRUG THERAPY; IONIC STRENGTH; PARAMETER ESTIMATION; SPECTROPHOTOMETRY; THERMODYNAMICS; TITRATION; TUMORS;

DRUG PRODUCTS;

10 HYDROXYCAMPTOTHECIN; 7 ETHYL 10 HYDROXYCAMPTOTHECIN; 7 ETHYLCAMPTOTHECIN; ANTINEOPLASTIC AGENT; CAMPTOTHECIN; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL MODEL; DISSOCIATION CONSTANT; EXPERIMENTATION; IONIC STRENGTH; LINEAR REGRESSION ANALYSIS; PH MEASUREMENT; PRIORITY JOURNAL; PROTON TRANSPORT; RELIABILITY; SPECTROPHOTOMETRY; TEMPERATURE; THERMODYNAMICS; TITRIMETRY;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CAMPTOTHECIN; HYDROGEN-ION CONCENTRATION; LEAST-SQUARES ANALYSIS; SPECTROPHOTOMETRY, ULTRAVIOLET; THERMODYNAMICS; TITRIMETRY;

EID: 33846562114     PISSN: 00032670     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.aca.2006.11.049     Document Type: Article

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