-
1
-
-
0034785483
-
A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2
-
Hadano S., Hand C.K., Osuga H., Yanagisawa Y., Otomo A., Devon R.S., Miyamoto N., Showguchi-Miyata J., Okada Y., Singaraja R., Figlewicz D.A., Kwiatkowski T., Hosler B.A., Sagie T., Skaug J., Nasir J., Brown Jr. R.H., Scherer S.W., Rouleau G.A., Hayden M.R., and Ikeda J.-E. A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2. Nat. Genet. 29 (2001) 166-173
-
(2001)
Nat. Genet.
, vol.29
, pp. 166-173
-
-
Hadano, S.1
Hand, C.K.2
Osuga, H.3
Yanagisawa, Y.4
Otomo, A.5
Devon, R.S.6
Miyamoto, N.7
Showguchi-Miyata, J.8
Okada, Y.9
Singaraja, R.10
Figlewicz, D.A.11
Kwiatkowski, T.12
Hosler, B.A.13
Sagie, T.14
Skaug, J.15
Nasir, J.16
Brown Jr., R.H.17
Scherer, S.W.18
Rouleau, G.A.19
Hayden, M.R.20
Ikeda, J.-E.21
more..
-
2
-
-
0034785509
-
The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis
-
Yang Y., Hentati A., Deng H.X., Dabbagh O., Sasaki T., Hirano M., Hung W.Y., Ouahchi K., Yan J., Azim A.C., Cole N., Gascon G., Yagmour A., Ben-Hamida M., Pericak-Vance M., Hentati F., and Siddique T. The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis. Nat. Genet. 29 (2001) 160-165
-
(2001)
Nat. Genet.
, vol.29
, pp. 160-165
-
-
Yang, Y.1
Hentati, A.2
Deng, H.X.3
Dabbagh, O.4
Sasaki, T.5
Hirano, M.6
Hung, W.Y.7
Ouahchi, K.8
Yan, J.9
Azim, A.C.10
Cole, N.11
Gascon, G.12
Yagmour, A.13
Ben-Hamida, M.14
Pericak-Vance, M.15
Hentati, F.16
Siddique, T.17
-
3
-
-
0029758214
-
p619, a giant protein related to the chromosome condensation regulator RCC1, stimulates guanine nucleotide exchange on ARF1 and Rab proteins
-
Rosa J.L., Casaroli-Marano R.P., Buckler A.J., Vilaro S., and Barbacid M. p619, a giant protein related to the chromosome condensation regulator RCC1, stimulates guanine nucleotide exchange on ARF1 and Rab proteins. EMBO J. 15 (1996) 4262-4273
-
(1996)
EMBO J.
, vol.15
, pp. 4262-4273
-
-
Rosa, J.L.1
Casaroli-Marano, R.P.2
Buckler, A.J.3
Vilaro, S.4
Barbacid, M.5
-
4
-
-
0036644975
-
Guanine nucleotide exchange factors for Rho GTPases: turning on the switch
-
Schmidt A., and Hall A. Guanine nucleotide exchange factors for Rho GTPases: turning on the switch. Genes Dev. 16 (2002) 1587-1609
-
(2002)
Genes Dev.
, vol.16
, pp. 1587-1609
-
-
Schmidt, A.1
Hall, A.2
-
5
-
-
30444436194
-
Vps9 domain-containing proteins: activators of Rab5 GTPases from yeast to neurons
-
Carney D.S., Davies B.A., and Horazdovsky B.F. Vps9 domain-containing proteins: activators of Rab5 GTPases from yeast to neurons. Trends Cell Biol. 16 (2006) 27-35
-
(2006)
Trends Cell Biol.
, vol.16
, pp. 27-35
-
-
Carney, D.S.1
Davies, B.A.2
Horazdovsky, B.F.3
-
6
-
-
0033636778
-
Junctophilins: a novel family of junctional membrane complex proteins
-
Takeshima H., Komazaki S., Nishi M., Iino M., and Kangawa K. Junctophilins: a novel family of junctional membrane complex proteins. Mol. Cell 6 (2000) 11-22
-
(2000)
Mol. Cell
, vol.6
, pp. 11-22
-
-
Takeshima, H.1
Komazaki, S.2
Nishi, M.3
Iino, M.4
Kangawa, K.5
-
8
-
-
0041308082
-
ALS2, a novel guanine nucleotide exchange factor for the small GTPase Rab5, is implicated in endosomal dynamics
-
Otomo A., Hadano S., Okada T., Mizumura H., Kunita R., Nishijima H., Showguchi-Miyata J., Yanagisawa Y., Kohiki E., Suga E., Yasuda M., Osuga H., Nishimoto T., Narumiya S., and Ikeda J.-E. ALS2, a novel guanine nucleotide exchange factor for the small GTPase Rab5, is implicated in endosomal dynamics. Hum. Mol. Genet. 12 (2003) 1671-1687
-
(2003)
Hum. Mol. Genet.
, vol.12
, pp. 1671-1687
-
-
Otomo, A.1
Hadano, S.2
Okada, T.3
Mizumura, H.4
Kunita, R.5
Nishijima, H.6
Showguchi-Miyata, J.7
Yanagisawa, Y.8
Kohiki, E.9
Suga, E.10
Yasuda, M.11
Osuga, H.12
Nishimoto, T.13
Narumiya, S.14
Ikeda, J.-E.15
-
9
-
-
4644247430
-
Homo-oligomerization of ALS2 through its unique carboxyl-terminal regions is essential for the ALS2-associated Rab5 guanine nucleotide exchange activity and its regulatory function on endosome trafficking
-
Kunita R., Otomo A., Mizumura H., Suzuki K., Showguchi-Miyata J., Yanagisawa Y., Hadano S., and Ikeda J.-E. Homo-oligomerization of ALS2 through its unique carboxyl-terminal regions is essential for the ALS2-associated Rab5 guanine nucleotide exchange activity and its regulatory function on endosome trafficking. J. Biol. Chem. 279 (2004) 38626-38635
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 38626-38635
-
-
Kunita, R.1
Otomo, A.2
Mizumura, H.3
Suzuki, K.4
Showguchi-Miyata, J.5
Yanagisawa, Y.6
Hadano, S.7
Ikeda, J.-E.8
-
11
-
-
14244264186
-
A Rac1/phosphatidylinositol 3-kinase/Akt3 anti-apoptotic pathway, triggered by AlsinLF, the product of the ALS2 gene, antagonizes Cu/Zn-superoxide dismutase (SOD1) mutant-induced motoneuronal cell death
-
Kanekura K., Hashimoto Y., Kita Y., Sasabe J., Aiso S., Nishimoto I., and Matsuoka M. A Rac1/phosphatidylinositol 3-kinase/Akt3 anti-apoptotic pathway, triggered by AlsinLF, the product of the ALS2 gene, antagonizes Cu/Zn-superoxide dismutase (SOD1) mutant-induced motoneuronal cell death. J. Biol. Chem. 280 (2005) 4532-4543
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 4532-4543
-
-
Kanekura, K.1
Hashimoto, Y.2
Kita, Y.3
Sasabe, J.4
Aiso, S.5
Nishimoto, I.6
Matsuoka, M.7
-
12
-
-
27144530084
-
ALS2/Alsin regulates Rac-PAK signaling and neurite outgrowth
-
Tudor E.L., Perkinton M.S., Schmidt A., Ackerley S., Brownlees J., Jacobsen N.J.O., Byers H.L., Ward M., Hall A., Leigh P.N., Shaw C.E., McLoughlin D.M., and Miller C.C.J. ALS2/Alsin regulates Rac-PAK signaling and neurite outgrowth. J. Biol. Chem. 280 (2005) 34735-34740
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 34735-34740
-
-
Tudor, E.L.1
Perkinton, M.S.2
Schmidt, A.3
Ackerley, S.4
Brownlees, J.5
Jacobsen, N.J.O.6
Byers, H.L.7
Ward, M.8
Hall, A.9
Leigh, P.N.10
Shaw, C.E.11
McLoughlin, D.M.12
Miller, C.C.J.13
-
13
-
-
2442463319
-
Alsin, the product of ALS2 gene, suppresses SOD1 mutant neurotoxicity through RhoGEF domain by interacting with SOD1 mutants
-
Kanekura K., Hashimoto Y., Niikura T., Aiso S., Matsuoka M., and Nishimoto I. Alsin, the product of ALS2 gene, suppresses SOD1 mutant neurotoxicity through RhoGEF domain by interacting with SOD1 mutants. J. Biol. Chem. 279 (2004) 19247-19256
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 19247-19256
-
-
Kanekura, K.1
Hashimoto, Y.2
Niikura, T.3
Aiso, S.4
Matsuoka, M.5
Nishimoto, I.6
-
14
-
-
4544335087
-
ALS2CL, the novel protein highly homologous to the carboxy-terminal half of ALS2, binds to Rab5 and modulates endosome dynamics
-
Hadano S., Otomo A., Suzuki-Utsunomiya K., Kunita R., Yanagisawa Y., Showguchi-Miyata J., Mizumura H., and Ikeda J.-E. ALS2CL, the novel protein highly homologous to the carboxy-terminal half of ALS2, binds to Rab5 and modulates endosome dynamics. FEBS Lett. 575 (2004) 64-70
-
(2004)
FEBS Lett.
, vol.575
, pp. 64-70
-
-
Hadano, S.1
Otomo, A.2
Suzuki-Utsunomiya, K.3
Kunita, R.4
Yanagisawa, Y.5
Showguchi-Miyata, J.6
Mizumura, H.7
Ikeda, J.-E.8
-
15
-
-
32344442372
-
Purification and functional analyses of ALS2 and its homologue
-
Balch W.E., Der C.J., and Hall A. (Eds), Elsevier Inc, San Diego, CA
-
Hadano S., and Ikeda J.-E. Purification and functional analyses of ALS2 and its homologue. In: Balch W.E., Der C.J., and Hall A. (Eds). GTPases Regulating Membrane Targeting and Fusion, Methods in Enzymology vol. 403 (2005), Elsevier Inc, San Diego, CA 310-321
-
(2005)
GTPases Regulating Membrane Targeting and Fusion, Methods in Enzymology
, vol.403
, pp. 310-321
-
-
Hadano, S.1
Ikeda, J.-E.2
-
16
-
-
0033202945
-
Rab5 regulates motility of early endosomes on microtubules
-
Nielsen E., Severin F., Backer J.M., Hyman A.A., and Zerial M. Rab5 regulates motility of early endosomes on microtubules. Nat. Cell Biol. 1 (1999) 376-382
-
(1999)
Nat. Cell Biol.
, vol.1
, pp. 376-382
-
-
Nielsen, E.1
Severin, F.2
Backer, J.M.3
Hyman, A.A.4
Zerial, M.5
-
17
-
-
33747605320
-
Molecular biology of amyotrophic lateral sclerosis: insights from genetics
-
Pasinelli P., and Brown R.H. Molecular biology of amyotrophic lateral sclerosis: insights from genetics. Nat. Rev. Neurosci. 7 (2006) 710-723
-
(2006)
Nat. Rev. Neurosci.
, vol.7
, pp. 710-723
-
-
Pasinelli, P.1
Brown, R.H.2
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