Prohibitin suppresses renal interstitial fibroblasts proliferation and phenotypic change induced by transforming growth factor-β1

Molecular and Cellular Biochemistry

Volumn 295, Issue 1-2, 2007, Pages 167-177

  Guo, Wei ^a   Xu, Hong ^a   Chen, Jing ^a   Yang, Yong ^b   Jin, Jia Wei ^b   Fu, Rui ^a   Liu, Hai Mei ^a   Zha, Xi Liang ^b   Zhang, Zhi Gang ^b   Huang, Wen Yan ^a  

^a CHILDREN S HOSPITAL OF FUDAN UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

Author keywords

Cell cycle; Cell phenotypic change; Fibroblast; Prohibitin; Transforming growth factor 1; Tubulointerstitial lesions

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CELL PROTEIN; CYTOKINE; MESSENGER RNA; PROHIBITIN; TRANSCRIPTION FACTOR E2F; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ADOLESCENT; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL CYCLE; CELL NUCLEUS; CELL PROLIFERATION; CHILD; CLINICAL ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOPLASM; DOWN REGULATION; DRUG TARGETING; FEMALE; FIBROBLAST; GENE EXPRESSION REGULATION; GENE REPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN TISSUE; KIDNEY BIOPSY; KIDNEY FIBROSIS; KIDNEY INTERSTITIUM; KIDNEY PARENCHYMA; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT;

ACTINS; ADOLESCENT; ANIMALS; BIOPSY; CELL NUCLEUS; CELL PROLIFERATION; CHILD; CHILD, PRESCHOOL; DOWN-REGULATION; FEMALE; FIBROBLASTS; FLOW CYTOMETRY; HUMANS; KIDNEY; MALE; MICROSCOPY, CONFOCAL; NEPHRITIS, INTERSTITIAL; PHENOTYPE; PROTEIN TRANSPORT; RATS; REPRESSOR PROTEINS; RNA, MESSENGER; TRANSFORMING GROWTH FACTOR BETA1;

RATTUS;

EID: 33846551247     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-006-9286-4     Document Type: Article

References (35)

1. Strutz F, Muller GA (1995) On the progression of chronic renal disease Nephron 69: 371-379
2. Bohle A, Muller GA, Wehrmann M, Mackensen-Haen S, Xiao JC (1996) Pathogenesis of chronic renal failure in the primary glomerulopathies, renal vasculopathies, and chronic interstitial nephritides Kidney Int 54: S2-S9
3. Eddy AA (2000) Molecular basis of renal fibrosis Pediatr Nephrol 15:290-301
4. Negri AL (2004) Prevention of progressive fibrosis in chronic renal diseases: Antifibrotic agents J Nephrol 17: 496-503
5. Kaneto H, Morrissey J, Klahr S (1993) Increased expression of TGF-b1 mRNA in the obstructed kidney of rats with unilateral uretheral ligation Kidney Int 44: 313-321
6. Yamamoto T, Noble NA, Miller DE, Border WA (1994) Sustained expression of TGF-b1 underlies development of progressive kidney fibrosis Kidney Int 45: 916-927
7. Yamamotto T, Nakamura T, Noble NA, Ruoslahti E, Border WA (1993) Expression of transforming growth factor-b is elevated in human and experimental diabetic nephropathy Proc Natl Acad Sci USA 90: 1814-1818
8. Cuhaci B, Kumar MS, Bloom RD, Pratt B, Haussman G, Laskow DA, Alidoost M, Grotkowski C, Cahill K, Butani L, Sturgill BC, Pankewycz OG (1999) Transforming growth factor-b levels in human allograft chronic fibrosis correlate with the rate of decline in renal function Transplantation 68: 785-790
9. Badid C, Vincent M, Fouque D, Laville M, Desmouliere A (2001) Myofibroblast: A prognosticmarker and target cell in progressive renal disease Ren Fail 23: 543-549
10. el Nahas AM, Muchaneta-Kubara EC, Zhang G, Adam A, Goumenos D (1996) Phenotypic modulation of renal cells during experimental and clinical renal scarring Kidney Int 54: S23-S27
11. Klahr S, Morrissey J (2002) Obstructive nephropathy and renal fibrosis Am J Physiol 283: F861-F875
12. De Heer E, Sijpkens YW, Verkade M, den Dulk M, Langers A, Schutrups J, Bruijn JA, van Es LA (2000) Morphometry of interstitial fibrosis Nephrol Dial Transpl 15:72-73
13. Huang WY, Sun H, Pan XQ, Guo M, Zhang AH, Wu YJ, Huang SM, Chen RH (2003) Screening of genes involved in renal interstitial fibrosis in rats with unilateral ureteral obstruction Chin J Pediatr 41: 855-856
14. Mishra S, Murphy LC, Nyomba BL, Murphy LJ (2005) PHB: A potential target for new therapeutics TRENDS Mol Med 11: 192-197
15. Thompson WE, Branch A, Whittaker JA, Lyn D, Zilberstein M, Mayo KE, Thomas K (2001) Characterization of PHB in a newly established rat ovarian granulosa cell line Endocrinology 142: 4076-4085
16. Nijtmans LG, Artal SM, Grivell LA, Coates PJ (2002) The mitochondrial PHB complex: Roles in mitochondrial respiratory complex assembly, ageing and degenerative disease Cell Mol Life Sci 59: 143-155
17. Artal-Sanz M, Tsang WY, Willems EM, Grivell LA, Lemire BD, van der Spek H, Nijtmans LG (2003) The mitochondrial prohibitin complex is essential for embryonic viability and germline function in Caenorhabditis elegans J Biol Chem 278: 32091-32099
18. Thompson WE, Ramalho-Santos J, Sutovsky P (2003) Ubiquitination of prohibitin in mammalian sperm mitochondria: Possible roles in the regulation of mitochondrial inheritance and sperm quality control Biol Reprod 69: 254-260
19. Jupe ER, Liu XT, Kiehlbauch JL, McClung JK, Dell'Orco TT (1996) The 3′ untranslated region of PHB and cellular immortalization Exp Cell Res 224: 128-135
20. Wang S, Fusaro G, Paddmanabhan J, Chellappan SP (2002) PHB co-localizes with Rb in the nucleus and recruits N-CoR and HDAC1 for transcriptional repression Oncogene 21: 8388-8396
21. Joshi B, Ko D, Ordonez-Ercan D, Chellappan SP (2003) A putative coiled-coil domain of prohibitin is sufficient to repress E2F1-mediated transcription and induce apoptosis Biochem Biophys Res Commun 312: 459-466
22. Fusaro G, Wang S, Chellappan S (2002) Differential regulation of Rb family proteins and prohibitin during camptothecin-induced apoptosis Oncogene 21: 4539-4548
23. Churg J, Bernstein J, Glassock RJ: In: Renal Disease Classification and atlas of glomerular disease, 2nd edn. Ikagu Shoin, New York, pp. 541-553, 1995
24. The Chinese Society of Pediatric Nephrology (2001) Clinical classification, diagnosis and treatment of glomerular diseases in children Chin J Pediatr 39: 746-749
25. Thomas SE, Anderson S, Gordon KL, Oyama TT, Shankland SJ, Johnson RJ (1988) Tubulointerstitial disease in aging: Evidence of underlying peritubular capillary damage, potential role for renal ischemia J Am Soc Nephrol 9: 231-242
26. Coates PJ, Nenutil R, McGregor A, Picksley SM, Crouch DH, Hall PA, Wright EG (2001) Mammalian PHB proteins respond to mitochondrial stress and decrease during cellular senescence Exp Cell Res 265: 262-273
27. Gamble SC, Odontiadis M, Waxman J (2004) Androgens target PHB to regulate proliferation of prostate cancer cells Oncogene 23: 2996-3004
28. Zeisberg M, Strutz F, Muller GA (2001) Renal fibrosis: An update Curr Opin Nephrol Hypertens 10: 315-320
29. Andrew L, David JA (2004) TGF-β1 signaling and the fibrotic response FASEB 18: 816-827
30. Bottinger EP, Bitzer M (2002) TGF-β1 signaling in renal disease J Am Soc Nephrol 13: 2600-2610
31. Moustakas A, Heldin CH (2005) Non-Smad TGF-β1 signals J Cel Sci 118: 3573-3584
32. Wang S, Nath N, Adlam M (1999) PHB, a potential tumor suppressor, interacts with RB and regulates E2F function Oncogene 18: 3501-3510
33. Shinae KK, Nobutake A, Hiroto O (2000) Role of TGF-beta; in EGF-induced transformation of NRK cells is sustaining high-level EGF-signaling FEBS Lett 466: 160-164
34. Satoshi O, Shinae KK, Yuko H (1998) Constitutive Association of EGF Receptor with the CrkII-23 Mutant that Inhibits Transformation of NRK Cells by EGF and TGF-β Cell Signal 10: 283-290
35. Wang S, Nath N, Fusaro G, Chellappan S (1999) Rb and PHB target distinct regions of E2F1for repression and respond to different upstream signals Mol Cell Biol 19: 7447-7460