In vivo radioprotective effects of Nigella sativa L oil and reduced glutathione against irradiation-induced oxidative injury and number of peripheral blood lymphocytes in rats

Photochemistry and Photobiology

Volumn 82, Issue 6, 2006, Pages 1691-1696

  Cemek, Mustafa ^a   Enginar, Hüseyin ^a   Karaca, Turan ^b   Ünak, Perihan ^c  

^a AFYON KOCATEPE UNIVERSITY   (Turkey)

^b YUZUNCU YIL UNIVERSITY   (Turkey)

^c EGE UNIVERSITY   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

CARAWAY OIL; GLUTATHIONE; RADIOPROTECTIVE AGENT; UNCLASSIFIED DRUG; VEGETABLE OIL;

ANIMAL; ARTICLE; DRUG EFFECT; INJECTION; LYMPHOCYTE; MALE; RADIATION EXPOSURE; RAT; WISTAR RAT;

ANIMALS; GLUTATHIONE; INJECTIONS; LYMPHOCYTES; MALE; PLANT OILS; RADIATION-PROTECTIVE AGENTS; RATS; RATS, WISTAR;

ANIMALIA; NIGELLA SATIVA; RATTUS;

EID: 33846546568     PISSN: 00318655     EISSN: None     Source Type: Journal    
DOI: 10.1562/2006-06-15-RA-924     Document Type: Article

References (49)

1. Jagetia, G. C. and T. K. Reddy (2005) Modulation of radiation-induced alteration in the antioxidant status of mice by naringin. Life Sci. 77, 780-794.
2. Nair, C. K. K., D. K. Parida and T. Nomura (2001) Radioprotectors in radiotherapy. J. Radiat. Res. 42, 21-37.
3. Kamat, J. P., K. K. Boloor, T. P. A. Devasagayam and S. R. Venkatachalam (2000) Antioxidant properties of Asparagus racemosus against damage induced by γ-radiation in rat liver mitochondria. J. Ethnopharmacol. 71, 425-435.
4. Lett, J. T. (1992) Damage to cellular DNA from particulate radiation, the efficacy of its processing and the radiosensitivity of mammalian cells. Emphasis on DNA strand breaks and chromatin break. Radiat. Environ. Biophys. 31, 257-277.
5. Daniniak, N. and B. J. Tann (1995) Utility of biological membranes as indicators for radiation exposure: Alterations in membrane structure and function over time. Stem Cells 13, 142-152.
6. Rice-Evans, C. and R. Burdon (1993) Free radical-lipid interaction and their pathological consequences. Prog. Lipid Res. 32, 71-110.
7. Stavric, B. (1994) Antimutagens and anticarcinogens in foods (review). Food Chem. Toxicol. 32, 79-90.
8. Halliwell, B. (1990) How to characterize a biological antioxidant. Free Radic. Res. Commun. 9, 1-32.
9. Salem, M. L. (2005) Immunomodulatory and therapeutic properties of the Nigella sativa L. seed. Int. Immunopharmacol. 5, 1749-1770.
10. El-Tahir, K. E. H., M. M. S. Ashour and M. M. Al-Harbi (1993) The respiratory effects of the volatile oil of the black seed (Nigella sativa) in guinea-pigs: Elucidation of the mechanism(s) of action. Gen. Pharmacol. 24, 1115-1122.
11. El-Dakhakhny, M., N. J. Madi, N. Lembert and H. P. Ammon (2002) Nigella sativa oil, nigellone and derived thymoquinone inhibit synthesis of 5-lipoxygenase products in polymorphonuclear leukocytes from rats. J. Ethnopharmacol. 81, 161-164.
12. Peterhans, E. (1997) Oxidants and antioxidants in viral diseases: Disease mechanisms and metabolic regulation. J. Nutr. 127, 962S-965S.
13. Akhter, M. S. and S. Riffat (1991) Field trail of Saussurea lappa roots against nematodes and Nigella sativa seed against cestodes in children. J. Pak. Med. Assoc. 41, 185-187.
14. Morsi, N. M. (2000) Antimicrobial effect of crude extracts of Nigella sativa on multiple antibiotics-resistant bacteria. Acta Microbiol. Pol. 49, 63-74.
15. Worthen, D. R., O. A. Ghosheh and P. A. Crooks (1998) The in vitro antitumor activity of some crude and purified components of blackseed, Nigella sativa L. Anticancer Res. 18, 1527-1532.
16. Swamy, S. M. and B. K. Tan (2000) Cytotoxic and immunopotentiating effects of ethanolic extract of Nigella sativa L. seeds. J. Ethnopharmacol. 70, 1-7.
17. Kanter, M., I. Meral, S. Dede, H. Gunduz, M. Cemek, H. Ozbek and I. Uygan (2003) Effects of Nigella sativa L. and Urtica dioica L. on lipid peroxidation, antioxidant enzyme systems and some liver enzymes in CC14-treated rats. J. Vet. Med. A Physiol. Pathol. Clin. Med. 50, 264-268.
18. Gul, M., F. Z. Kutay, S. Temocin and O. Hanninen (2000) Cellular and clinical implications of glutathione. Indian J. Exp. Biol. 38, 625-634.
19. Meister, A. and M. E. Anderson (1983) Glutathione. Ann. Rev. Biochem. 52, 711-760.
20. Sen, C. K. (1997) Nutritional biochemistry of cellular glutathione. J. Nutr. Biochem. 8, 660-672.
21. Maiti, N. K., S. S. Saini and S. N. Sharma (1990) Histochemical studies on chicken peripheral blood lymphocytes. Vet. Res. Commun. 14, 207-210.
22. Kipnis, J., H. Avidan, Y. Markovich, T. Mirzahi, E. Hauben, T. B. Prigozhina, S. Slavin and M. Schwartz (2004) Low-dose γ-irradiation promotes survival of injured neurons in the central nervous system via homeostasis-driven proliferation of lymphocytes. Eur. J. Neurosci. 19, 1191-1198.
23. Vijayalaxmi, R. J. R., E. Sewerynek, B. Poeggeler, B. Z. Leal and M. L. Meltz (1995) Marked reduction of radiation-induced micronuclei in human blood lymphocytes pretreated with melatonin. Radiat. Res. 143, 102-106.
24. Jain, S. K., R. McVie, J. Duett and J. J. Herbst (1989) Erythrocyte membrane lipid peroxidase and glycolylated hemoglobin in diabetes. Diabetes 38, 1539-1543.
25. Griffith, O. W. (1980) Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. Anal. Biochem. 106, 207-212.
26. Miranda, K. M., M. G. Espey and D. A. Wink (2001) A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite. Nitric Oxide 5, 62-71.
27. Omaye, S. T., J. D. Turnbul and H. E. Savberlich (1979) Ascorbic acid analysis. II. Determination after derivatisation with 2.2. dinitrophenylhidrazine. Selected methods for determination of ascorbic acid in animal cells tissues and fluids. In Methods in Enzymology, 62 (Edited by D. B. McCormick and L. D. Wright), pp. 7-8. Academic Press, New York.
28. Suzuki, I. and N. Katoh (1990) A simple and cheap method for measuring serum vitamin A in cattle using spectrophotometer. Jpn. J. Vet. Sci. 52, 1281-1283.
29. Schosinsky, K. H., H. P. Lehmann and M. F. Beeler (1974) Measurement of ceruloplasmin from its oxidase activity in serum by use of o-dianisidine dihydrochloride. Clin. Chem. 20, F556-1563.
30. Karbownik, M. and R. J. Reiter (2000) Antioxidative effects of melatonin in protection against cellular damage caused by ionizing radiation. Proc. Soc. Exp. Biol. Med. 225, 9-22.
31. Halliwell B. (1996) Antioxidants in human health and disease. Ann. Rev. Nutr. 16, 33-50.
32. Karpen, C. W., A. J. Merola, R. W. Trewyn, D. G. Cornwell and R. V. Panganamala (1981) Modulation of platelet thromboxane A2 and arterial prostacyclin by dietary vitamin E. Prostaglandins 22, 651-656.
33. Jeon, S. M., S. H. Bok, M. K. Jang, Y. H. Kim, K. T. Nam, T. S. Jeong, Y. B. Park and M. S. Choi (2002) Comparison of antioxidant effects of naringin and probucol in cholesterol-fed rabbits. Clin. Chim. Acta 317, 181-190.
34. Noda, Y., P. L. Mcgeer, E. G. Mcgeer and M. Comporti (1993) Lipid peroxidation. Biopathological significance. Mol. Aspects Med. 14, 199-207.
35. Karslioǧlu, I., M. V. Ertekin, S. Taysi, I. Koçer, O. Sezen, A. Gepdiremen, M. Koc and N. Bakan (2005) Radioprotective effects of melatonin on radiation-induced cataract. J. Radiat. Res. 46, 277-282.
36. Koc, M., S. Taysi, M. E. Büyükokuroǧlu and N. Bakan (2003) Melatonin protects rat liver against irradiation-induced oxidative injury. J. Radiat. Res. 44, 211-215.
37. Hari Kumar, K. B. and R. Kuttan (2004) Protective effect of an extract of Phyllanthus amarus against radiation-induced damage in mice. J. Radiat. Res. 45, 133-139.
38. Türkoǧlu, U. M., Y. Erbil, S. Öztezcan, V. Olgac, G. Toker and M. Uysal (2000) The effect of selenium and/or vitamin E treatments on radiation-induced intestinal injury in rats. Life Sci. 66, 1905-1913.
39. Taysi, S., M. Koc, M. E. Büyükokuroǧlu, K. Altinkaynak and Y. N. Şahin (2003) Melatonin reduces lipid peroxidation and nitric oxide during irradiation-induced oxidative injury in the rat liver. J. Pineal Res. 34, 173-177.
40. Abu-Shakra, A., E. T. McQueen and M. L. Cunningham (2000) Rapid analysis of base-pair substitutions induced by mutagenic drugs through their oxygen radical or epoxide derivatives. Mutat. Res. 470, 11-18.
41. El-Sokkary, G. H., H. M. Omar, A. F. Hassanein, S. Cuzzocrea and R. J. Reiter (2002) Melatonin reduces oxidative damage and increases survival of mice infected with Schistosoma mansoni. Free. Radic. Biol. Med. 32, 319-332.
42. Gilad, E., S. Cuzzocrea, B. Zingarelli, A. L. Salzman and C. Szabo (1997) Melatonin is a scavenger of peroxynitrite. Life Sci. 60, 169-174.
43. Agrawal, A., D. Chandra and R. K. Kale (2001) Radiation induced oxidative stress: II studies in liver as a distant organ of tumor bearing mice. Mol. Cell. Biochem. 224, 9-17.
44. Iddamaldeniya, S. S., M. I. Thabrew, S. M. Wickramasinghe, N. Ratnatunge and M. G. Thammitiyagodage (2006) A long-term investigation of the anti-hepatocarcinogenic potential of an indigenous medicine comprised of Nigella sativa, Hemidesmus indicus and Smilax glabra. J Carcinog. 9, 5-11.
45. El-Aziz, M. A., H. A. Hassan, M. H. Mohamed, A. R. Meki, S. K. Abdel-Ghaffar and M. R. Hussein (2005) The biochemical and morphological alterations following administration of melatonin, retinoic acid and Nigella sativa in mammary carcinoma: An animal model. Int. J. Exp. Pathol. 86, 383-396.
46. Bump, E. A. and J. M. Brown (1990) Role of glutathione in the radiation response of mammalian cells in vitro and in vivo. Pharmacol. Ther. 47, 117-136.
47. Ragan, H. A., R. D. Philips, R. L. Buschom, R. H. Busch and J. E. Morris (1983) Hematologic and immunologic effects of pulsed microwaves in mice. Bioelectromagnetics 4, 383-389.
48. Trosi, I., I. Busljeta and I. Pavicic (2004) Blood-forming system in rats after whole-body microwave exposure; reference to the lymphocytes. Toxicol. Lett. 154, 125-132.
49. Koc, M., M. E. Büyükokuroǧlu and S. Taysi (2002) The effect of melatonin on peripheral blood cells during total body irradiation in rats. Biol. Pharm. Bull. 25, 656-657.