On-line HPLC combined with multivariate statistical process control for the monitoring of reactions

Analytica Chimica Acta

Volumn 584, Issue 2, 2007, Pages 370-378

  Zhu, Lifeng ^a   Brereton, Richard G ^a   Thompson, Duncan R ^b   Hopkins, Paul L ^b   Escott, Richard E A ^b  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Chromatography; Multivariate statistical process control (MSPC); On line high performance liquid chromatography (HPLC); Process monitoring

Indexed keywords

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMPURITIES; ONLINE SYSTEMS; PROBLEM SOLVING; SOLVENTS; STATISTICAL PROCESS CONTROL;

MULTIVARIATE STATISTICAL PROCESS CONTROL (MSPC); ON-LINE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC); PROCESS MONITORING; REACTION MONITORING;

REACTION KINETICS;

ARTICLE; CHEMICAL REACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MONITORING; MULTIVARIATE ANALYSIS; ONLINE ANALYSIS; PRIORITY JOURNAL;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FACTOR ANALYSIS, STATISTICAL; ONLINE SYSTEMS;

EID: 33846524346     PISSN: 00032670     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.aca.2006.11.045     Document Type: Article

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