Endometrial expression of epithelial neutrophil-activating peptide-78 during the menstrual cycle or in progestin-only contraceptive users with breakthrough bleeding and the influence of doxycycline therapy

Human Reproduction

Volumn 22, Issue 2, 2007, Pages 427-433

  Chegini, N ^a   Luo, X ^a   Pan, Q ^a   Rhoton Vlasak, A ^a   Archer, D F ^b  

^a UNIVERSITY OF FLORIDA   (United States)

^b EASTERN VIRGINIA MEDICAL SCHOOL   (United States)

Author keywords

Doxycycline; ENA 78; Endometrium; Ovarian steroids; Uterine bleeding

Indexed keywords

DOXYCYCLINE; EPITHELIAL DERIVED NEUTROPHIL ACTIVATING FACTOR 78; ESTRADIOL; GESTAGEN; LEVONORGESTREL; MEDROXYPROGESTERONE ACETATE; PLACEBO; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AMENORRHEA; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BREAKTHROUGH BLEEDING; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG SAFETY; ENDOMETRIUM BIOPSY; ENDOMETRIUM CELL; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MENSTRUAL CYCLE; PROTEIN BLOOD LEVEL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; SIDE EFFECT; STROMA CELL; TREATMENT DURATION; UTERINE BLEEDING PATTERN;

ENA;

EID: 33846513027     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/del398     Document Type: Article

References (31)

1. Brown DL, Desai KK, Vakili BA, Nouneh C, Lee HM and Golub LM (2004) Clinical and biochemical results of the metalloproteinase inhibition with subantimicrobial doses of doxycycline to prevent acute coronary syndromes (MIDAS) pilot trial. Arterioscler Thromb Vasc Biol 24,733-738.
2. Burkman RT, Collins JA, Shulman LP and Williams JK (2001) Current perspectives on oral contraceptive use. Am J Obstet Gynecol 185,S4-S12.
3. Cameron IT (2001) The levonorgestrel intrauterine system: The benefits of reduced bleeding. Eur J Contracept Reprod Health Care 6,27-32.
4. Chegini N, Ma C, Roberts M, Williams RS and Ripps BA (2002) Differential expression of interleukins (IL) IL-13 and IL-15 throughout the menstrual cycle in endometrium of normal fertile women and women with recurrent spontaneous abortion. J Reprod Immunol 56,93-110.
5. Dunn TS, Stamm CA, Delorit M and Goldberg G (2001) Clinical pathway for evaluating women with abnormal uterine bleeding. J Reprod Med 46,831-834.
6. Gear AR and Camerini D (2003) Platelet chemokines and chemokine receptors: Linking hemostasis, inflammation, and host defense. Microcirculation 10,335-350.
7. Imaizumi T, Albertine KH, Jicha DL, McIntyre TM, Prescott SM and Zimmerman GA (1997) Human endothelial cells synthesize ENA-78: relationship to IL-8 and to signaling of PMN adhesion. Am J Respir Cell Mol Biol 17,181-192.
8. Imaizumi T, Hatakeyama. M, Taima K, Ishikawa A, Yamashita K, Yoshida H and Satoh K (2004) Effect of double-stranded RNA on the expression of epithelial neutrophil activating peptide-78/CXCL-5 in human endothelial cells. Inflammation 28,215-219.
9. Jabbour HN, Kelly RW, Fraser HM and Critchley HO (2006) Endocrine regulation of menstruation. Endocr Rev 27,17-46.
10. Jones RL, Morison NB, Hannan NJ, Critchley HO and Salamonsen LA (2005) Chemokine expression is dysregulated in the endometrium of women using progestin-only contraceptives and correlates to elevated recruitment of distinct leukocyte populations. Hum Reprod 20,2724-2735.
11. Kaitu'u TJ, Shen J, Zhang J, Moris NB and Salamonsen LA (2005) Matrix metalloproteinases in endometrial breakdown and repair: Functional significance in a mouse model. Biol Reprod 73,672-680.
12. King CA, Anderson R and Marshall JS (2002) Dengue virus selectively induces human mast cell chemokine production. J Virol 76,8408-8419.
13. Koch AE, Kunkel SL, Harlow LA, Mazarakis DD, Haines GK, Burdick MD, Pope RM, Walz A and Strieter RM (1994) Epithelial neutrophil activating peptide-78: A novel chemotactic cytokine for neutrophils in arthritis. J Clin Invest 94,1012-1018.
14. Lee HM, Ciancio SG, Tuter G, Ryan ME, Komaroff E and Golub LM (2004) Subantimicrobial dose doxycycline efficacy as a matrix metalloproteinase inhibitor in chronic periodontitis patients is enhanced when combined with a non-steroidal anti-inflammatory drug. J Periodontol 75,453-463.
15. Li R, Luo X, Pan Q, Zeneh I, Archer DF, Williams RS and Chegini N (2006) Doxycycline alters the expression of inflammatory and immune-related cytokines and chemokines in human endometrial cells: Implication in irregular uterine bleeding. Hum Reprod 21,2555-2563.
16. Lukacs NW, Hogaboam CM, Kunkel SL, Chensue SW, Burdick MD, Evanoff HL and Strieter RM (1998) Mast cells produce ENA-78, which can function as a potent neutrophil chemoattractant during allergic airway inflammation. J Leukoc Biol 63,746-751.
17. Luo X, Ding L and Chegini N (2004) Gonadotropin-releasing hormone and TGF-beta activate MAP kinase and differentially regulate fibronectin expression in endometrial epithelial and stromal cells. Am J Physiol Endocrinol Metab 287,E991-E1001.
18. McLoughlin RM, Hurst SM, Nowell MA, Harris DA, Horiuchi S, Morgan LW, Wilkinson TS, Yamamoto N, Topley N and Jones SA (2004) Differential regulation of neutrophil-activating chemokines by IL-6 and its soluble receptor isoforms. J Immunol 172,5676-5683.
19. Munro MG (2001) Dysfunctional uterine bleeding: Advances in diagnosis and treatment. Curr Opin Obstet Gynecol 13,475-489.
20. Nasu K, Arima K, Kai K, Fujisawa K, Nishida M and Miyakawa I (2001) Expression of epithelial neutrophil-activating peptide 78 in cultured human endometrial stromal cells. Mol Hum Reprod 7,453-458.
21. Preshaw PM, Hefti AF, Jepsen S, Etienne D, Walker C and Bradshaw MH (2004) Subantimicrobial dose of doxycycline as adjunctive treatment for periodontitis. J Clin Periodontol 31,697-707.
22. Rhoton-Vlasak A, Chegini N, Hardt N and Williams RS (2005) Histological characteristics and altered expression of interleukins (IL) IL-13 and IL-15 in endometria of levonorgestrel users with different uterine bleeding patterns. Fertil Steril 83,659-665.
23. Roberts M, Luo X and Chegini N (2006) Differential regulation of interleukins IL-13 and IL-15 by ovarian steroids, TNF-α and TGF-β in human endometrial epithelial and stromal cells. Mol Hum Reprod 11,751-760.
24. Salamonsen LA, Zhang J and Brasted M (2002) Leukocyte networks and human endometrial remodelling. J Reprod Immunol 57,95-108.
25. Salvi GE and Lang NP (2005) Host response modulation in the management of periodontal diseases. J Clin Periodontol 32,108-129.
26. Siemonsma MA, de Hingh IH, de Man BM, Lomme RM, Verhofstad AA and Hendriks T (2004) Doxycycline improves wound strength after intestinal anastomosis in the rat. Surgery 133,268-276.
27. Smith OP and Critchley HO (2005) Progestogen only contraception and endometrial breakthrough bleeding. Angiogenesis 8,117-126.
28. Suzuki S, Kobayashi M, Chiba K, Horiuchi I, Wang J, Kondoh T, Hashino S, Tanaka J, Hosokawa M and Asaka M (2002) Autocrine production of epithelial cell-derived neutrophil attractant-78 induced by granulocyte colony-stimulating factor in neutrophils. Blood 99,1863-1865.
29. Toth A, Lesser ML, Naus G, Brooks C and Adams D (1988) Effect of doxycycline on pre-menstrual syndrome: A double-blind randomized clinical trial. J Int Med Res 16,270-279.
30. Walters MD and Gibbs RS (1990) A randomized comparison of gentamicinclindamycin and cefoxitin-doxycycline in the treatment of acute pelvic inflammatory disease. Obstet Gynecol 75,867-872.
31. Weisberg E, Hickey M, Palmer D, O'Connor V, Salamonsen LA, Findlay JK and Fraser IS (2006) A pilot study to assess the effect of three short-term treatments on frequent and/or prolonged bleeding compared to placebo in women using Implanon. Hum Reprod 21,295-302.