Determination of traces of fipronil and its metabolites in pollen by liquid chromatography with electrospray ionization-tandem mass spectrometry

Journal of Agricultural and Food Chemistry

Volumn 54, Issue 26, 2006, Pages 9741-9746

  Kadar, Ali ^a   Faucon, Jean Paul ^a  

^a Healthy Pigs Production and Experimentation Section   (France)

Author keywords

Electrospray ionization; Fipronil; Liquid chromatography; Mass spectrometry mechanism; Metabolites; Method validation; Normalized guidance; Pollen; Tandem mass spectrometry

Indexed keywords

FIPRONIL; INSECTICIDE; PYRAZOLE DERIVATIVE;

ARTICLE; CHEMISTRY; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; METHODOLOGY; POLLEN; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; INSECTICIDES; POLLEN; PYRAZOLES; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

APIS MELLIFERA;

EID: 33846507398     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf062035+     Document Type: Article

References (16)

1. Index Phytosanitaire ACTA 2006, 42nd ed.; Couteux, A., Lejeune, V., Ed.; Association de coordination Technique Agricole: Paris, France, 2006; p 167.
2. Cole, L. M.; Nicholson, R. A.; Casida, J. E. Action of phenylpyrazole insecticides at the GABA-gated chloride channel. Pestic. Biochem. Physiol. 1993, 46 (1), 47-54.
3. Mohamed, F.; Senarathna, L.; Percy, A.; Abeyewardene, M.; Eaglesham, G.; Cheng, R.; Azher, S.; Hittarage, A.; Dissanayake, W.; Sheriff, M. H. R.; Davies, W.; Buckley, N. A.; Eddleston, M. Acute human self-poisoning with the N-phenylpyrazole insecticide fipronil - a GABA(A)-gated chloride channel blocker. J. Toxicol. Clin. Toxicol. 2004, 42 (7), 955-963.
4. Sammelson, R. E.; Caboni, P.; Durkin, K. A.; Casida, J. E. GABA receptor antagonists and insecticides: common structural features of 4-alkyl-1- phenylpyrazoles and 4-alkyl-1-phenyltrioxabicyclooctanes. Bioorg. Med. Chem. 2004, 12 (12), 3345-3355.
5. Aajoud, A.; Raveton, M.; Aouadi, H.; Tissut, M.; Ravanel, P. Uptake and xylem transport of fipronil in sunflower. J. Agric. Food. Chem. 2006, 54, 5055-5060.
6. Colin, M. E.; Bonmatin, J. M.; Moineau, I.; Gaimon, C.; Brun, S.; Vermandere, J. P. A method to quantify and analyze the foraging activity of honey bees: relevance to the sublethal effects induced by systemic insecticides. Arch. Environ. Contam. Toxicol. 2004, 47 (3), 387-395.
7. Decourtye, A.; Devillers, J.; Genecque, E.; Le, M. K.; Budzinski, H.; Cluzeau, S.; Pham-Delegue, M. H. Comparative sublethal toxicity of nine pesticides on olfactory learning performances of the honeybee Apis mellifera. Arch. Environ. Contam. Toxicol. 2005, 48 (2), 242-250.
8. El Hassani, A. K.; Dacher, M.; Gauthier, M.; Armengaud, C. Effects of sublethal doses of fipronil on the behavior of the honeybee (Apis mellifera). Pharmacol. Biochem. Behav. 2005, 82 (1), 30-39.
9. Morzycka, B. Simple method for the determination of trace levels of pesticides in honeybees using matrix solid-phase dispersion and gas chromatography. J. Chromatogr. A 2002, 982 (2), 267-273.
10. Vilchez, J. L.; Prieto, A.; Araujo, L.; Navalon, A. Determination of fipronil by solid-phase microextraction and gas chromatography-mass spectrometry. J. Chromatogr. A 2001, 919 (1), 215-221.
11. Hainzl, D.; Cole, L. M.; Casida, J. E. Mechanisms for selective toxicity of fipronil insecticide and its sulfone metabolite and desulfinyl photoproduct. Chem. Res. Toxicol. 1998, 1529-1535.
12. Beeler, A. B.; Schlenk, D. K.; Rimoldi, J. M. Synthesis of fipronil Sulfide, an active metabolite, from the parent insecticide fipronil. Tetrahedron Lett. 2001, 42 (32), 5371-5372.
13. Analysis of agri-foodstuffs - intralaboratory procedure for an alternative method compared to a reference method - case of quantitative analysis methods. In NF V 03-110; Association Francaise de Normalisation: Paris, France, 1998; pp 1-40.
14. The Pesticide Manual, 10th ed.; Tomlin, C. D. S., Ed.; British Crop Protection Council: Surrey, U.K., 1994; p 463.
15. Slobodnik, J.; van Baar, B. L. M.; Brinkman, U. A. T. Column liquid chromatography-mass spectrometry: selected techniques in environmental applications for polar pesticides and related compounds. J. Chromatogr. A 1995, 703 (1-2), 81-121.
16. Sommerville, D. C. Lipid content of honey bee-collected pollen from south-east Australia. J. Exp. Agric. 2006, 45 (12), 1659-1661.