Evaluation of broad-spectrum anthelmintic activity in a novel assay against Haemonchus contortus, Trichostrongylus colubriformis and T. sigmodontis in the gerbil Meriones unguiculatus

Journal of Helminthology

Volumn 80, Issue 4, 2006, Pages 393-396

  Ostlind, D A ^a   Cifelli, S ^b   Mickle, W G ^b   Smith, S K ^b   Ewanciw, D V ^b   Rafalko, B ^b   Felcetto, T ^b   Misura, A ^b  

^a Merck Research Laboratories ^*  (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALBENDAZOLE; ANTHELMINTIC AGENT; BENZIMIDAZOLE DERIVATIVE; IMIDAZOTHIAZOLE; IVERMECTIN; LEVAMISOLE; MACROLIDE; MORANTEL; OXFENDAZOLE; PARAHERQUAMIDE; PLACEBO; PYRIMIDINE DERIVATIVE; TETRAHYDROPYRIMIDINE; THIAZOLE DERIVATIVE; TIABENDAZOLE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTHELMINTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; FEMALE; GERBIL; HAEMONCHUS CONTORTUS; MALE; NONHUMAN; TRICHOSTRONGYLOSIS; TRICHOSTRONGYLUS; TRICHOSTRONGYLUS COLUBRIFORMIS;

ALBENDAZOLE; ANIMALS; ANTHELMINTICS; BENZIMIDAZOLES; FEMALE; GERBILLINAE; HAEMONCHIASIS; HAEMONCHUS; INDOLIZINES; IVERMECTIN; LEVAMISOLE; MALE; MORANTEL; PARASITIC SENSITIVITY TESTS; SPIRO COMPOUNDS; THIABENDAZOLE; TRICHOSTRONGYLOIDEA; TRICHOSTRONGYLOIDIASIS; TRICHOSTRONGYLUS;

GERBILLINAE; HAEMONCHUS CONTORTUS; MERIONES UNGUICULATUS; NEMATODA; TRICHOSTRONGYLUS COLUBRIFORMIS;

EID: 33846502676     PISSN: 0022149X     EISSN: None     Source Type: Journal    
DOI: 10.1017/JOH2006371     Document Type: Article

References (16)

1. Campbell, W.C. (1983) Progress and prospects in the chemotherapy of nematode infections of man and other animals. Journal of Nematology 15, 608-615.
2. Conder, G.A., Jen, L.-W., Marbury, K.S., Johnson, S.S., Guimond, P.M., Thomas, E.M. & Lee, B.L. (1990) A novel anthelmintic model utilizing jirds, Meriones unguiculatus, infected with Haemonchus contortus. Journal of Parasitology 76, 168-170.
3. Court, J.P. & Lees, G.M. (1985) The efficacy of benzimidazole anthelmintics against late fourth stage larvae of Trichostrongylus colubriformis in gerbils and Nippostrongylus brasiliensis in rats. Veterinary Parasitology 18, 359-365.
4. Court, J.P., Lees, G.M., Coop, R.L., Angus, K.W. & Beesley, J.E. (1988) An attempt to produce Ostertagia circumcincta infections in mongolian gerbils. Veterinary Parasitology 28, 79-91.
5. Gonzalez, I.C., Davis, L.N. & Smith, C.K. II (2004) Novel thiophenes and analogues with anthelmintic activity against Haemonchus contortus. Bioorganic and Medicinal Chemistry Letters 14, 4037-4043.
6. Johnson, S.S., Coscarelli, E.M., Davis, J.P., Zaya, R.M., Day, J.S., Barsuhn, C.L., Martin, R.A., Vidmar, T.J., Lee, B.H., Conder, G.A., Geary, T.G., Ho, N.F.H. & Thompson, D.P. (2004) Interrelationships among physicochemical properties, absorption and anthelmintic activities of 2-desoxoparaherquamide and selected analogs. Journal of Veterinary Pharmacology and Therapeutics 27, 169-181.
7. Kates, K.C. & Thompson, D.E. (1967) Activity of three anthelmintics against mixed infections of two Trichostrongylus species in gerbils, sheep and goats. Proceedings of the Helminthological Society of Washington 34, 228-236.
8. Leland, S.E. (1963) Preliminary evaluation of Trichostrongylus axei in the Mongolian gerbil as a screening system for anthelmintics of domestic animals. Journal of Parasitology 49(Sect. 2), 15-16.
9. Meinke, P.T., Sinclair, P., Mrozik, H., O'Connor, S., Ostlind, D.A., Shoop, W.L., Arison, B.H. & Fisher, M.H. (1992) Synthesis of avermectin B1-4″,4″a-oxide: a precursor of potent anthelmintic agents. Bioorganic and Medicinal Chemistry Letters 2, 537-540.
10. Mrozik, H., Eskola, P., Fisher, M.H., Egerton, J.R., Cifelli, S. & Ostlind, D.A. (1982) Avermectin acyl derivatives with anthelmintic activity. Journal of Medicinal Chemistry 25, 658-663.
11. Ostlind, D.A. & Cifelli, S. (1981) Efficacy of thiabendazole, levamisole hydrochloride and the major natural avermectins against Trichostrongylus colubriformis in the gerbil (Meriones unguiculatus). Research in Veterinary Science 31, 255-256.
12. Panitz, E. & Shum, K.L. (1981) Efficacy of four anthelmintics in Trichostrongylus axei or T. colubriformis infections in the gerbil. Meriones unguiculatus. Journal of Parasitology 67, 135-136.
13. Schulman, M.D., Valentino, D., Hensens, O.D., Zink, D., Nallin, M., Kaplan, L. & Ostlind, D.A. (1985) Demethylavermectins, biosynthesis, isolation and characterization. Journal of Antibiotics 38, 1494-1498.
14. Shoop, W.L., Egerton, J.R., Eary, C.H. & Suhayda, D. (1990) Anthelmintic activity of paraherquamide in sheep. Journal of Parasitology 76, 349-351.
15. Shoop, W.L., Michael, B.F., Haines, H.W. & Eary, C.H. (1992) Anthelmintic activity of paraherquamide in calves. Veterinary Parasitology 43, 259-263.
16. Williams, G.A.H. & Palmer, B.H. (1964) Trichostrongylus colubriformis (a nematode parasite of sheep and other ruminants) as a test organism in screening for sheep anthelmintics in the laboratory. Nature 203, 1399-1400.