Development and validation of a liquid chromatography-tandem mass spectrometry for the determination of BPR0L075, a novel antimicrotuble agent, in rat plasma: Application to a pharmacokinetic study

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 846, Issue 1-2, 2007, Pages 162-168

  Chang, Yi Wei ^a   Chen, Wei Cheng ^a   Lin, Ke Ta ^a   Chang, Ling ^a   Yao, Hsien Tsung ^a   Hsieh, Hsing Pang ^a   Lan, Shih Jung ^a   Chen, Chiung Tong ^a   Chao, Yu Sheng ^a   Yeh, Teng Kuang ^a  

^a NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

Author keywords

Bioanalysis; BPR0L075; LC MS MS; Pharmacokinetics; Validation

Indexed keywords

BIOANALYSIS; BPR0L075; LC-MS/MS; VALIDATION;

ANIMAL CELL CULTURE; BIOASSAY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PHARMACOKINETICS;

ORGANIC COMPOUNDS;

1 METHYL 6 METHOXY 3 (3',5' DIMETHOXYBENZOYL) 1H INDOLE; 6 METHOXY 3 (3',4',5' TRIMETHOXYBENZOYL) 1H INDOLE; ACETONITRILE; AMMONIUM ACETATE; BPR0L 075; BPR0L 092; FORMIC ACID; INDOLE DERIVATIVE; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL EXPERIMENT; ARTICLE; BOLUS INJECTION; CALIBRATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG STABILITY; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; PRECIPITATION; PRIORITY JOURNAL; QUALITY CONTROL; QUANTITATIVE ANALYSIS; RAT; SINGLE DRUG DOSE; STANDARD; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS;

ANIMALS; CHROMATOGRAPHY, LIQUID; INDOLES; MITOSIS; RATS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

RATTUS;

EID: 33846501675     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2006.08.040     Document Type: Article

References (6)

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