Aging and atrial fibrillation research: Where we are and where we should go

Heart Rhythm

Volumn 4, Issue 2, 2007, Pages 186-187

  Pandit, Sandeep V ^a   Jalife, José ^a  

^a State University of New York Upstate Medical University: College of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INWARDLY RECTIFYING POTASSIUM CHANNEL;

AGING; CALCIUM CURRENT; CELL INTERACTION; CHANNEL GATING; CLINICAL FEATURE; EDITORIAL; HEART ATRIUM ARRHYTHMIA; HEART ATRIUM FIBRILLATION; HEART BLOCK; HEART ELECTROPHYSIOLOGY; HEART MUSCLE CELL; HEART MUSCLE CONDUCTION DISTURBANCE; HEART MUSCLE FIBROSIS; HEART MUSCLE POTENTIAL; HEART REPOLARIZATION; HUMAN; MEDICAL RESEARCH; PATHOGENESIS; PRIORITY JOURNAL; SODIUM CURRENT;

ACTION POTENTIALS; AGED; AGING; ANISOTROPY; CARDIAC COMPLEXES, PREMATURE; CONNEXINS; FEMALE; HEART ATRIA; HEART CONDUCTION SYSTEM; HUMANS; ION CHANNELS; MALE; MEMBRANE POTENTIALS; MIDDLE AGED; MODELS, CARDIOVASCULAR;

EID: 33846488923     PISSN: 15475271     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.hrthm.2006.11.011     Document Type: Editorial

References (22)

1. Hyun D.-H., Hernandez J.O., Mattson M.P., and de Cabo R. The plasma membrane redox system in aging. Ageing Res Rev 5 (2006) 209-220
2. Blasco M.A. Telomeres and human disease: ageing, cancer and beyond. Nat Rev Genet 6 (2005) 611-622
3. Go A.S. The epidemiology of atrial fibrillation in elderly persons: the tip of the iceberg. Am J Geriatr Cardiol 14 (2005) 56-61
4. Allessie M.A., Boyden P.A., Camm A.J., Kleber A.G., Lab M.J., Legato M.J., Rosen M.R., Schwartz P.J., Spooner P.M., Van Wagoner D.R., and Waldo A.L. Pathophysiology and prevention of atrial fibrillation. Circulation 103 (2001) 769-777
5. Anyukhovsky E.P., Sosunov E.A., Chandra P., Rosen T.S., Boyden P.A., Danilo Jr. P., and Rosen M.R. Age-associated changes in electrophysiologic remodeling: a potential contributor to initiation of atrial fibrillation. Cardiovasc Res 66 (2005) 353-363
6. Anyukhovsky E.P., Sosunov E.A., Plotnikov A., Gainullin R.Z., Jhang J.S., Marboe C.C., and Rosen M.R. Cellular electrophysiologic properties of old canine atria provide a substrate for arrhythmogenesis. Cardiovasc Res 54 (2002) 462-469
7. Weber K.T., Pick R., Jalil J.E., Janicki J.S., and Carroll E.P. Patterns of myocardial fibrosis. J Mol Cell Cardiol 21 Suppl 5 (1989) 121-131
8. Allessie M., Schotten U., Verheule S., and Harks E. Gene therapy for repair of cardiac fibrosis. A long way to Tipperary. Circulation 111 (2005) 391-393
9. Spach M.S., Heidlage J.F., Barr R.C., and Dolber P.C. Cell size and communication: role in structural and electrical development and remodeling of the heart. Heart Rhythm 1 (2004) 500-515
10. Spach M.S., and Dolber P.C. Relating extracellular potentials and their derivatives to anisotropic propagation at a microscopic level in human cardiac muscle. Evidence for electrical uncoupling of side-to-side fiber connections with increasing age. Circ Res 58 (1986) 356-371
11. de Bakker J.M., and van Rijen H.M. Continuous and discontinuous propagation in heart muscle. J Cardiovasc Electrophysiol 17 (2006) 567-573
12. Narayan S.M., Bode F., Karasik P.L., and Franz M.R. Alternans of atrial action potentials during atrial flutter as a precursor to atrial fibrillation. Circulation 106 (2002) 1968-1973
13. Spach M.S., Heidlage J.F., Dolber P.C., and Barr R.C. Mechanism of origin of conduction disturbances in aging human atrial bundles: experimental and model study. Heart Rhythm 4 (2007) 175-185
14. Spach M.S., and Heidlage J.F. The stochastic nature of cardiac propagation at a microscopic level. Electrical description of myocardial architecture and its application to conduction. Circ Res 76 (1995) 366-380
15. Nygren A., Fiset C., Firek L., Clark J.W., Lindblad D.S., Clark R.B., and Giles W.R. Mathematical model of an adult human atrial cell: the role of K+ currents in repolarization. Circ Res 82 (1998) 63-81
16. Chen P.S., Wolf P.D., Dixon E.G., Danieley N.D., Frazier D.W., Smith W.M., and Ideker R.E. Mechanism of ventricular vulnerability to single premature stimuli in open-chest dogs. Circ Res 62 (1988) 1191-1209
17. Dobrev D., and Ravens U. Remodeling of cardiomyocyte ion channels in human atrial fibrillation. Basic Res Cardiol 98 (2003) 137-148
18. Dhamoon A.S., and Jalife J. The inward rectifier current (IK1) controls cardiac excitability and is involved in arrhythmogenesis. Heart Rhythm 2 (2005) 316-324
19. Jalife J. Rotors and spiral waves in atrial fibrillation. J Cardiovasc Electrophysiol 14 (2003) 776-780
20. Miragoli M., Gaudesius G., and Rohr S. Electrotonic modulation of cardiac impulse conduction by myofibroblasts. Circ Res 98 (2006) 801-810
21. Camelliti P., Green C.R., LeGrice I., and Kohl P. Fibroblast network in rabbit sinoatrial node: structural and functional identification of homogeneous and heterogeneous cell coupling. Circ Res 94 (2004) 828-835
22. Kamkin A., Kiseleva I., Isenberg G., Wagner K.D., Gunther J., Theres H., and Scholz H. Cardiac fibroblasts and the mechano-electric feedback mechanism in healthy and aged hearts. Prog Biophys Mol Biol 82 (2003) 111-120